Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mosapride citrate pharmaceutical composition

A technology of mosapride citrate and its composition, which is applied in the field of pharmaceutical preparations, can solve the problems of sudden release effect, unfavorable commercial production, cumbersome preparation process, etc., and achieve improved compliance and safety, and smooth release , The effect of simple preparation process

Active Publication Date: 2019-10-22
CHANGZHOU HANSOH PHARM CO LTD
View PDF15 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process announced by this patent is cumbersome, with poor reproducibility and high energy consumption, which is not in line with the current general trend of energy conservation and environmental protection, and is not conducive to commercial production
In addition, the patented product is prone to burst release effect in the presence of alcohol, which will lead to serious adverse feedback

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mosapride citrate pharmaceutical composition
  • Mosapride citrate pharmaceutical composition
  • Mosapride citrate pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Prescription

[0033] Element proportion Mosapride Citrate 20.21％ Xanthan Gum 18％ polyvinyl acetate 9％ Hydroxyethyl cellulose 8％ Mannitol 42.79％ silica 1％ talcum powder 1％

[0034] (2) Preparation

[0035] Mosapride citrate is subjected to airflow pulverization treatment, polyvinyl acetate and hydroxyethyl cellulose are subjected to wet granulation and drying treatment, and the treated mosapride citrate is mixed with wet granulation dry product, yellow Raw gum and mannitol were added to the hopper mixer, mixed at 15 rpm for 40 minutes, silicon dioxide was added, mixed at 15 rpm for 10 minutes, talcum powder was added, mixed for 5 minutes, tableted according to the content controlled in the center, and coated with Opadry.

Embodiment 2

[0037] (1) Prescription

[0038]

[0039]

[0040] (2) Preparation

[0041]Mosapride citrate is subjected to airflow pulverization treatment, polyvinyl acetate and povidone are subjected to spray drying treatment, and the treated mosapride citrate is mixed with the spray-dried product, glyceryl behenate, lactose Add to the hopper mixer, mix at 15rpm for 40min, add silicon dioxide, mix at 15rpm for 10min, add sodium lauryl sulfate, mix for 5min, press the tablet according to the content controlled in the center, coat with Opadry, increase the weight by 2% .

Embodiment 3

[0043] (1) Prescription

[0044]

[0045] (2) Preparation

[0046] The mosapride citrate is jet crushed, the polyvinyl acetate and polyvinyl alcohol are spray-dried, and the treated mosapride citrate and the spray-dried product, chitosan, and lactose are added to the hopper Mixer, mix at 15rpm for 40min, add silicon dioxide, mix at 15rpm for 10min, add magnesium stearate, mix for 5min, perform tablet compression according to the content in the middle control, coat with Opadry, and increase the weight by 2%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a mosapride citrate pharmaceutical composition. The composition comprises mosapride citrate, a slow-release agent, a diluent, a flow aid, a lubricant and the like. The composition is gentle in release rate, free of initial burst release effect, high in stability, capable of improving the medication compliance of a patient, high in medication safety and small in toxic and side effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition of mosapride citrate. Background technique [0002] Mosapride citrate (Formula 1), chemical name (±)-4 chloro-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-mol Phenyl]methyl]benzamide dihydrate citrate, a selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist, stimulates gastrointestinal cholinergic interneurons and myenteric plexuses It promotes the release of acetylcholine, thereby enhancing the motility of the gastrointestinal tract, improving the gastrointestinal symptoms of patients with functional dyspepsia, and does not affect the secretion of gastric acid. It is clinically used for functional dyspepsia with gastrointestinal symptoms such as heartburn, belching, nausea, vomiting, early satiety, and upper abdominal distension; it can also be used for gastroesophageal reflux disease, diabetic gastroparesis, and gastritis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/28A61K47/36A61K47/14A61K47/44A61K47/38A61K47/32A61K31/5375A61P1/14A61P1/08A61P1/04
CPCA61K9/2013A61K9/2027A61K9/205A61K9/2054A61K9/2068A61K9/28A61K31/5375A61P1/04A61P1/08A61P1/14
Inventor 樊继涛董礼杨宝海韩颜
Owner CHANGZHOU HANSOH PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com