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Gold-platinum co-modified graphene electrode and its preparation method and application

A graphene electrode and co-modification technology, which is applied to electrochemical variables of materials, material analysis by electromagnetic means, instruments, etc., can solve the problems of low accuracy, difficulty in automation, time-consuming and the like, and achieves a simple preparation method, Large specific surface area and high accuracy

Active Publication Date: 2021-04-13
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the current research on electrochemical immunosensors is still in the basic experimental stage, which cannot meet the requirements for sensitivity, stability and detection range in clinical testing; moreover, there is still a lack of biosensing applications in miniaturization and nanomaterials. Systematic research cannot fully realize the real-time, rapid and ultra-sensitive detection of complex biological samples
[0004] During the occurrence and development of tumors, the content of tumor markers in the blood is often accompanied by an increase. The method for quantitative detection of tumor markers is usually immunoassay. However, traditional immunoassay techniques are time-consuming, inaccurate, and difficult to implement Disadvantages such as automation

Method used

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  • Gold-platinum co-modified graphene electrode and its preparation method and application
  • Gold-platinum co-modified graphene electrode and its preparation method and application
  • Gold-platinum co-modified graphene electrode and its preparation method and application

Examples

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preparation example Construction

[0078] 15) Preparation method of glycine solution: add phosphoric acid dropwise into the phosphate buffer solution to make the pH of the phosphate buffer solution 2.4, and use the phosphate buffer solution to prepare a 0.1-0.2 mol / L glycine solution.

[0079] All reagents mentioned above were of analytical grade.

[0080] In the following examples, the involved instruments and models are as follows:

[0081] 1. Electrochemical workstation (CHI660E): Shanghai Chenhua Instrument Co., Ltd.

[0082] 2. Ultraviolet lamp (305nm): Shanghai Hualun Bulb Factory

[0083] 3. Magnetic stirrer (BII-2): Shanghai Sile Instrument Co., Ltd.

[0084] 4. SHZ-D(III) circulating water vacuum pump: Hebei Yuhua Instrument Co., Ltd. (for suction filtration)

[0085] 5. Constant temperature incubator (DH3600B II): Tianjin Test Instrument Co., Ltd.

[0086] 6. Nitrogen generator (SPN-500A): Beijing Zhonghui Analysis Technology Research Institute

[0087] 7. Youpu series ultrapure water device (UPH...

Embodiment 1

[0092] A preparation method of gold-platinum co-modified graphene electrode, comprising the following steps:

[0093] Step 1, prepare a glassy carbon sheet of 2cm×1cm and a thickness of 1mm, polish it clean, clean the glassy carbon sheet, and clean the glassy carbon sheet to remove organic and inorganic substances (dirt) on the surface of the glassy carbon sheet. The specific steps are: Purified water, absolute ethanol and ultrapure water were successively ultrasonically cleaned for 10 minutes, and dried at room temperature 25°C for 10 minutes.

[0094] Step 2, carry out direct current plasma chemical vapor deposition: put the glassy carbon sheet obtained in step 1 into the center of the sample stage in the sample chamber of direct current plasma chemical vapor deposition equipment, close the sample chamber (chamber) and evacuate to below 1Pa, and inject the The chamber is filled with argon and hydrogen at the same time. When filling, the flow rate of hydrogen is 2L / min, and t...

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Abstract

The invention discloses a gold-platinum co-modified graphene electrode and its preparation method and application. The preparation method of the gold-platinum co-modified graphene electrode comprises the following steps: cleaning the glassy carbon sheet, and putting the glassy carbon sheet into a DC plasma chemical gas phase Vacuumize the sample chamber of the deposition equipment, fill the sample chamber with inert gas and hydrogen, spray methane into the sample chamber after heating up, end the DC plasma chemical vapor deposition, and use the graphene glassy carbon sheet as the working Electrode, the three-electrode system that working electrode, counter electrode and reference electrode constitute is inserted in electrolyte, connect electrochemical workstation, adopt multi-potential step method to electrochemically reduce and deposit gold on the surface of described graphene glassy carbon sheet Platinum nanoparticles, the deposition time is 1 to 5 minutes, and after cleaning, a gold-platinum co-modified graphene electrode is obtained. The quantitative detection of tumor markers using the gold-platinum co-modified graphene electrode of the present invention has the characteristics of miniaturization, semi-automatic, high accuracy and the like.

Description

technical field [0001] The invention belongs to the technical field of electrochemical biosensors, and in particular relates to a gold-platinum co-modified graphene electrode and a preparation method and application thereof. Background technique [0002] Cancer is a general term for a large class of malignant tumors and is one of the major diseases threatening human health. Tumor markers, as a class of molecules that reflect the presence of tumors, exist in human blood and tissues. Their identification is of great significance for the early prevention of cancer. [0003] Electrochemical immunosensors have been receiving much attention in the application of tumor marker detection, and nanomaterials have greatly expanded the detection sensitivity of electrochemical immunosensors, which is of great significance for the early diagnosis of tumors. Most of the current research on electrochemical immunosensors is still in the basic experimental stage, which cannot meet the require...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327G01N27/48G01N33/53
CPCG01N27/3277G01N27/3278G01N27/48G01N33/53
Inventor 李明吉郑思雨李红姬李翠平钱莉荣杨保和
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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