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A kind of medical artificial joint material and preparation method thereof

A technology of artificial joints and mixed materials, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of macrophage phagocytosis, deterioration of material comprehensive performance, and material oxidation and brittleness, etc., to promote blood circulation and service life. The effect of long, wear-resistant high-strength anti-oxidation properties

Active Publication Date: 2021-09-03
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during long-term use, the organic polymer joint material is constantly worn and produces wear debris, which easily stimulates the phagocytosis of macrophages, triggers osteolysis, and leads to loosening and dislocation of the prosthesis. Second revision surgery is required, and the service life is short
[0005] The Chinese invention patent with application publication number CN 107754013 A discloses a high-antioxidation, high-crosslinking ultra-high molecular weight polyethylene artificial joint material and a preparation method thereof. The artificial joint material is composed of polyphenol antioxidant epigallocatechin gallate or The fat-soluble epigallocatechin gallate modified by palmitoyl chloride esterification is composed of biocompatible ultra-high molecular weight polyethylene, which is obtained by irradiation crosslinking after molding. The comprehensive performance of this joint material Excellent, the service time is long, but the residual free radicals produced by radiation are bound in the crystal phase and are difficult to eliminate. Long-term service will cause the material to oxidize and become brittle. Although the addition of oxidants can improve the oxidation resistance of the material to a certain extent, However, it can also lead to a decrease in the overall performance of the material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of a medical artificial joint material, comprising the steps of:

[0035] Ⅰ Modified ultra-high molecular weight polyethylene: Mix 3kg ultra-high molecular weight polyethylene, 1kg vinyltrimethoxysilane, 0.01kg benzophenone peroxide, and 0.01kg dibutyltin dilaurate to form a mixture, and then mix The material is added to a twin-screw extruder for extrusion molding to obtain modified ultra-high molecular polyethylene; the process parameters of the extrusion molding are: the heating temperature is 225°C, the extrusion temperature of the head is 240°C, and the extruder Main screw speed 150r / min, feeding speed 200r / min;

[0036] Preparation of Ⅱ addition polymer: ethylene glycolic acid 1kg, N5-[(allyloxy)carbonyl]ornithine 1kg, titanium (4+) 2-methacrylate 2-propanol (1:1:3 ) 0.3kg, 2kg of methyl methacrylate, and 0.01kg of azobisisobutyronitrile were mixed evenly, and then stirred and reacted for 4 hours under a nitrogen atmosphere at 70°C to prepare ...

Embodiment 2

[0042] A preparation method of a medical artificial joint material, comprising the steps of:

[0043] Ⅰ Modified ultra-high molecular weight polyethylene: Mix 3.5kg ultra-high molecular weight polyethylene, 1kg vinyltrimethoxysilane, 0.01kg benzoyl peroxide, and 0.015kg monobutyltin oxide to form a mixture, and then mix The material is added to a twin-screw extruder for extrusion molding to obtain modified ultra-high molecular polyethylene; the process parameters of the extrusion molding are: the heating temperature is 227°C, the extrusion temperature of the head is 242°C, and the extruder The main screw speed is 152r / min, and the feeding speed is 203r / min;

[0044] Preparation of Ⅱ addition polymer: ethylene glycolic acid 1kg, N5-[(allyloxy)carbonyl]ornithine 1kg, titanium (4+) 2-methacrylate 2-propanol (1:1:3 ) 0.3kg, 2kg of methyl methacrylate, and 0.02kg of azobisisobutyronitrile were uniformly mixed, then stirred and reacted for 4.5 hours in a helium atmosphere at 72°C t...

Embodiment 3

[0050] A preparation method of a medical artificial joint material, comprising the steps of:

[0051] Ⅰ Modified ultra-high molecular weight polyethylene: Mix 4kg of ultra-high molecular weight polyethylene, 1kg of vinyltrimethoxysilane, 0.01kg of dicyclohexyl peroxydicarbonate, and 0.02kg of dioctyltin dilaurate to form a mixture. Finally, the mixture is added to a twin-screw extruder for extrusion molding to obtain modified ultra-high molecular polyethylene; the process parameters of the extrusion molding are: the heating temperature is 230 ° C, the extrusion temperature of the head is 245 ° C, The main screw speed of the extruder is 155r / min, and the feeding speed is 205r / min;

[0052] Preparation of Ⅱ addition polymer: ethylene glycolic acid 1kg, N5-[(allyloxy)carbonyl]ornithine 1kg, titanium (4+) 2-methacrylate 2-propanol (1:1:3 ) 0.3kg, 2kg of methyl methacrylate, and 0.02kg of azobisisobutyronitrile were uniformly mixed, then stirred and reacted at 75°C for 5 hours in ...

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PUM

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Abstract

The invention discloses a preparation method of a medical artificial joint material, comprising the following steps: (1) modified ultra-high molecular weight polyethylene; (2) preparation of polyaddition; (3) Ti-Ce-Ge-Cr-Ta Preparation of alloy powder; (4) surface modification of Ti-Ce-Ge-Cr-Ta alloy powder; (5) molding of artificial joint materials. The invention also discloses the medical artificial joint material prepared according to the preparation method of the medical artificial joint material. The medical artificial joint material disclosed by the invention has the advantages of low preparation cost, high wear resistance, high strength and high oxidation resistance, good biological fixation performance with host bone tissue, long service life, non-toxicity and good biocompatibility.

Description

technical field [0001] The invention relates to the technical field of materials for implant devices, in particular to a medical artificial joint material and a preparation method thereof. Background technique [0002] With the development of modern medicine and materials science, medical prosthetics, artificial joints, bone fixators, dental implants, heart valve covers, etc. are used to manufacture medical devices, prostheses or artificial organs and auxiliary treatment equipment implanted in the human body. The application in the medical and health field is becoming more and more extensive. As this type of operation becomes more and more mature, the demand for artificial joints has increased significantly, and the above-mentioned components have made great progress in terms of biocompatibility, strength, plasticity, and corrosion resistance. Artificial joints have remarkable effects in the treatment of joint deformities and various destructive bone and joint diseases. Many...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/06A61L27/16A61L27/20C22C30/00
CPCA61L27/446A61L27/50A61L2430/24B22F9/04B22F9/082C08F220/14C08F255/02C22C14/00C22C30/00C08L23/06C08L5/04C08F230/085C08F230/04C08F220/365C08F220/04
Inventor 万迎春邓生卫
Owner 湖南博隽生物医药有限公司
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