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Nattokinase enteric-coated tablet and preparation method thereof

A technology of soybean kinase intestine and nattokinase, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of inability to prevent thrombosis, inability to regulate blood pressure, and thrombolysis Poor effect and other problems, to avoid the damage of gastric juice, reduce the loss, and prevent the formation of thrombus

Inactive Publication Date: 2019-05-07
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because nattokinase mainly enters the blood after being absorbed in the small intestine to dissolve thrombus, the first two nattokinase products will lose most of their enzyme activity in gastric acid, and their utilization rate in the body is extremely low, which plays a role in reducing blood clots. However, although nattokinase soft capsules can ensure that the capsule shell does not decompose in gastric juice, so that nattokinase can play a role in the small intestine, because the existence form of nattokinase in soft capsules is liquid, and the enzyme activity of nattokinase is lost quickly in the liquid state, so there are also defects such as short validity period and high preparation cost
In addition, the most important thing is that none of the above-mentioned nattokinase products can regulate blood pressure. Therefore, it can only dissolve thrombosis but cannot prevent thrombosis

Method used

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  • Nattokinase enteric-coated tablet and preparation method thereof
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  • Nattokinase enteric-coated tablet and preparation method thereof

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preparation example Construction

[0049] In order to prepare the above-mentioned nattokinase enteric-coated tablets, the present invention also proposes a preparation method of nattokinase enteric-coated tablets, combining figure 1 The schematic flow chart of an embodiment of the preparation method of nattokinase enteric-coated tablet provided, as can be seen, the preparation method of described nattokinase enteric-coated tablet comprises the following steps:

[0050] Step S10, crushing and sieving: take nattokinase, astragalus extract, filler, binder, lubricant, disintegrating agent and coating material, respectively crush, pass through a 100-120 mesh sieve, and set aside.

[0051] Crushing and sieving can reduce the particle size of raw and auxiliary materials, increase the specific surface area of ​​the drug, improve the bioavailability, make the ingredients can be mixed evenly, and be easy to form into tablets. The 100-120 mesh sieve mentioned above is a standard drug sieve, and its mesh meets GB / T6003.1-2...

Embodiment 1

[0069] Weigh 30g of nattokinase, 10g of astragalus extract, 45g of filler (microcrystalline cellulose), 10g of binder (dextrin), and 1g of lubricant (magnesium stearate) that have been pulverized and processed through a 100-mesh sieve. , disintegrant (sodium carboxymethyl starch) 5g and coating material (acrylic resin No. II and acrylic resin No. III mixture) 4g.

[0070] Dissolve the above-mentioned nattokinase and astragalus extract in water, add part of the above-mentioned filler and mix to form a mixture with a water content of 40% (w / w), and vacuum-dry the mixture at 30°C, and then pass it for 60 Mesh sieve to obtain a mixed powder with a water content of 5% (w / w); the above-mentioned binder is dissolved in water to obtain a binder solution with a concentration of 10% (w / v); the mixed powder, binder The agent solution and the rest of the above-mentioned fillers are evenly mixed to obtain a soft material.

[0071] Sieve the soft materials to obtain wet granules, vacuum-dr...

Embodiment 2

[0076] Weigh respectively 35g of nattokinase, 15g of astragalus extract, 35g of filler (starch), 8g of binder (gelatin), 2g of lubricant (polyethylene glycol), and 2g of disintegrating agent that have been crushed and processed through a 100-mesh sieve. (Carboxymethylcellulose) 6g and coating material (cellulose acetate phthalate) 5g.

[0077] Dissolve the above-mentioned nattokinase and astragalus extract in water, add part of the above-mentioned filler and mix to form a mixture with a water content of 50% (w / w). The mixture is vacuum-dried at 25°C, and then dried for 50 Mesh sieve to obtain a mixed powder with a water content of 3% (w / w); the above binder is dissolved in water to obtain a binder solution with a concentration of 5% (w / v); the mixed powder, binder The agent solution and the rest of the above-mentioned fillers are evenly mixed to obtain a soft material.

[0078] Sieve the soft materials to obtain wet granules, dry them under vacuum microwave at 25°C, and then ...

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Abstract

The invention discloses a nattokinase enteric-coated tablet and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The enteric-coated tablet includes a core tablet and a enteric coating layer; the core tablet is prepared by, by weight, 30-35 parts of nattokinase, 10-15 parts of a radix astragali extract product, 35-55 parts of a filler, 4-15 parts of an adhesive, 0.1-3 parts of a lubricant, and 2-10 parts of a disintegrating agent; and the enteric coating layer includes 3-6 parts of a coating material. The preparation method includes crushing and sieving, soft material making, granulation, total mixing, tabletting and coating. The enteric-coated tablet has the efficacy of adjusting blood pressure and dissolving thrombus, and can prevent the formation of the thrombus.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a nattokinase enteric-coated tablet and a preparation method thereof. Background technique [0002] Thrombus is a small block formed by blood flow on the surface of the spalled or repaired part of the inner surface of the cardiovascular system. When the thrombus blocks the blood vessel, it will cause insufficient blood supply to local tissues or organs, and in severe cases, ischemic necrosis of tissues or organs will occur. High blood pressure can increase the resistance of small blood vessel smooth muscle, damage the vascular endothelium, and increase the chance of thrombosis. Although blood pressure can be kept stable by taking antihypertensive drugs, it cannot solve the high coagulation state of blood, nor can it fundamentally solve the problem of thrombus, which is the root cause of stroke and myocardial infarction in hypertensive patients. Therefore, in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/32A61K47/38A61K38/48A61P7/02A61K36/481
Inventor 刘梁潘显虎赵玲陈新熊学敏
Owner WUHAN POLYTECHNIC UNIVERSITY
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