Composition for enhancing drug safety and clinical efficacy of low concentration atropines

Abstract

The present invention discloses a composition capable of enhancing the drug safety and clinical efficacy of low concentration atropines, and especially when the composition is used in low concentration atropines eye drops, the fact that the composition used in the low concentration atropines eye drops provided by the invention can effectively improve the drug safety of low concentration atropinesby adjusting key quality parameters such as pH, osmotic pressure and viscosity of the eye drops is creatively discovered, especially for improving clinical efficacy, so as to effectively solve the problems in the use of current low-concentration atropines eye drops, such as poor safety, large efficacy differences, unstable main drugs, safety of impurities degradation, concomitant adverse reactionsand other side effects. The composition enhances the clinical efficacy of low concentration atropines eye drops in the prevention and treatment of myopia of adolescents and children and provides a safer and healthier guarantee for the eyesight of adolescents and children, and has a very broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic medication of pharmaceutical preparations, and in particular relates to a composition for enhancing the safety and clinical efficacy of low-concentration atropine drugs and a preparation method thereof. Background technique [0002] According to a survey on the prevention and treatment of myopia in children jointly conducted by China, the United States and Australia, the number of myopia in my country has reached nearly 450 million, and the number of myopia cases ranks first in the world. The incidence of myopia has reached 1.5 times the world average. The rate is as high as 50% to 60%. As the learning pressure of young students in our country continues to increase, the current young people in my country have become the main group of myopia, which has a great impact on their future work, study and life, and has become the top priority of the current disease control work . With the entry of vari...

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the low-concentration atropine drug eye drops in the process of preventing and treating adolescents and children's myopia, the safety and clinical curative effect of the low-concentration atropine drug in the solution are affected by the composition of the used composition and present a greater difference. The problem of differences in safety and clinical efficacy, creatively proposed a composition and its preparation method that can enhance the safety and clinical efficacy of low-concentration atropine drugs, especially for eye drops, through a lot of research work, surprisingly found A composition that can enhance the safety and clinical efficacy of low-concentration atropine drug eye drops can effectively solve the instability of the main drug and the safety and accompanying adverse effects of impurity degradation during the use of current low-concentration atropine drug eye drops In addition, it can effectively enhance the clinical efficacy of drugs, give full play to the use of low-concentration atropine drug eye drops in the prevention and treatment of myopia in adolescents and children, improve the safety and efficacy mechanism of drugs, and improve the eyesight and vision of adolescents and children. Physical health provides safety and efficacy guarantee

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