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Calamine lotion with bacteriostatic effect

A technology of calamine lotion and antibacterial effect, which is applied in the direction of local antibacterial agents, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the limitations of clinical application of calamine lotion, suspension Insufficient performance, no bactericidal effect, etc., to improve suspension performance, enhance water absorption and expansion performance, and improve anti-inflammatory effects

Pending Publication Date: 2019-04-26
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The addition of the broad-spectrum antibiotic gentamicin can inhibit the growth of bacteria in the solution. However, the addition of gentamicin makes this calamine lotion no longer suitable for all people, and it will be banned for those who are allergic to gentamicin At the same time, gentamicin has a certain degree of ototoxicity, which limits the clinical application of calamine lotion
[0005] And calamine lotion has deficiencies such as insufficient suspension performance, weak antipruritic effect, and no bactericidal effect in the specific application process

Method used

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  • Calamine lotion with bacteriostatic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] A calamine lotion with antibacterial effect, made of the following raw materials in parts by weight: 140 parts of modified calamine, 45 parts of zinc oxide, 5 parts of modified nano-zinc oxide, 8 parts of medicinal phenol, antibiotic 6 parts, 10 parts of menthol, 20 parts of Tween 20, 7 parts of glycerin, 2 parts of sodium carboxymethylcellulose, 800 parts of purified water;

[0068] Described calamine lotion is made by following steps:

[0069] Step S1, adding sodium carboxymethyl cellulose to purified water 10 times its mass, stirring and dissolving to make sodium carboxymethyl cellulose solution;

[0070] Step S2, mixing medicinal phenol and antibiotics, adding them into purified water according to the solid-to-liquid ratio of 1 g: 25 mL, heating to raise the temperature of the purified water to 68° C., and stirring to dissolve all the solids to obtain the first mixed solution;

[0071] Step S3, mixing Tween 20 and glycerin, stirring evenly to obtain a second mixed ...

Embodiment 2

[0077] A calamine lotion with antibacterial effect is made of the following raw materials in parts by weight: 150 parts of modified calamine, 50 parts of zinc oxide, 6 parts of modified nano-zinc oxide, 9 parts of medicinal phenol, antibiotic 7 parts, 11 parts of menthol, 23 parts of Tween 20, 8.5 parts of glycerin, 2.5 parts of sodium carboxymethylcellulose, 850 parts of purified water;

[0078] Described calamine lotion is made by following steps:

[0079] Step S1, adding sodium carboxymethyl cellulose to purified water whose mass is 13 times larger, stirring and dissolving to make a sodium carboxymethyl cellulose solution;

[0080] Step S2, mixing medicinal phenol and antibiotics, adding them into purified water according to the solid-to-liquid ratio of 1 g: 28 mL, heating to raise the temperature of the purified water to 70° C., and stirring to dissolve all the solids to obtain the first mixed solution;

[0081] Step S3, mixing Tween 20 and glycerin, stirring evenly to ob...

Embodiment 3

[0087] A calamine lotion with antibacterial effect is made of the following raw materials in parts by weight: 160 parts of modified calamine, 55 parts of zinc oxide, 7 parts of modified nano-zinc oxide, 10 parts of medicinal phenol, antibiotic 8 parts, 12 parts of menthol, 26 parts of Tween 20, 10 parts of glycerin, 3 parts of sodium carboxymethylcellulose, 900 parts of purified water;

[0088] Described calamine lotion is made by following steps:

[0089] Step S1, adding sodium carboxymethyl cellulose to purified water 15 times its mass, stirring and dissolving to make sodium carboxymethyl cellulose solution;

[0090] Step S2, mixing medicinal phenol and antibiotics, adding them into purified water according to the solid-to-liquid ratio of 1 g: 30 mL, heating to raise the temperature of the purified water to 72°C, and stirring to dissolve all the solids to obtain the first mixed solution;

[0091] Step S3, mixing Tween 20 and glycerin, stirring evenly to obtain a second mixe...

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Abstract

The invention discloses calamine lotion with a bacteriostatic effect. The calamine lotion is prepared from the following raw materials in parts by weight: 140-160 parts of modified calamine, 45-55 parts of zinc oxide, 5-7 parts of modified nano zinc oxide, 8-10 parts of officinal phenol, 6-8 parts of antibiotic, 10-12 parts of menthol, 20-26 parts of tween 20, 7-10 parts of glycerinum, 2-3 parts of sodium carboxymethylcellulose, and 800-900 parts of purified water. The calamine lotion disclosed by the invention takes the modified calamine and the zinc oxide as main effective ingredients of thelotion, wherein the anti-bacterial, convergent, antiseptic and antipruritic effects of the both ingredients are strong; through adding a proper amount of the modified nano zinc oxide, the lotion is endowed with good antibacterial performance; the officinal phenol is capable of prolonging a using expiration date of a preparation, increasing stability of the preparation, and enhancing the sterilizing, bacteriostatic and antipruritic effects of the preparation; in addition, in a preparation process of the calamine lotion, a sodium carboxymethylcellulose suspending agent is added to increase thestability of suspension; and the calamine lotion with the bacteriostatic effect, stable characters and a strong physiological property is prepared.

Description

technical field [0001] The invention belongs to the technical field of calamine lotion, in particular to a calamine lotion with antibacterial effect. Background technique [0002] Calamine lotion is a commonly used external medicine with a long clinical application time. It has the effect of astringent and skin protection, and is suitable for acute pruritus skin diseases such as urticaria and prickly heat. [0003] There are many preparation methods of calamine lotion, the most common is to add 50g of calamine, 150g of zinc oxide and 50ml of glycerin, add an appropriate amount of water, grind, add water to make 1000ml, mix well, and get ready. But the calamine lotion obtained by this traditional preparation method has the defects of poor suspension performance and poor stability. [0004] Chinese patent CN102813674A discloses another preparation method of calamine lotion. The lotion contains 150 grams of calamine, 50 grams of zinc oxide, 50 milliliters of glycerin, 10 grams...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K33/30A61K47/38A61K47/69A61P17/00A61P17/04A61P31/02C01G9/00C01G9/02A61K31/045A61K31/05A61K31/165
CPCA61K9/0014A61K9/10A61K31/045A61K31/05A61K31/165A61K33/30A61K47/38A61K47/6951A61P17/00A61P17/04A61P31/02C01G9/00C01G9/02A61K2300/00
Inventor 蒋锋周健陈梦琦候珂兰王顺
Owner JIANGSU PENGYAO PHARMA
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