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Compositions for the treatment of ischemic ulcers and stretch marks

一种组合物、化合物的技术，应用在药物组合、有机活性成分、梳妆用配制品等方向，能够解决破坏组织、身体特定部位大小增加、结缔组织结构破裂等问题

Inactive Publication Date: 2019-04-16
SERVICIO ANDALUZA DE SALU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Infection leads to the release of striatoxin, which destroys tissue through microbial toxins
[0007] 2. Mechanical effects of stretching, which can lead to rupture of connective tissue structures (eg, pregnancy, obesity, weightlifting)
[0008] 3. Normal growth and pubertal stretching as seen in adolescence leads to an increase in the size of specific body parts
[0048] A large number of treatment strategies exist for the above conditions (stretch scars and skin ulcers), and no single method is more consistent than the rest

Method used

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  • Compositions for the treatment of ischemic ulcers and stretch marks
  • Compositions for the treatment of ischemic ulcers and stretch marks
  • Compositions for the treatment of ischemic ulcers and stretch marks

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0154] This example concerns the case of an 11-year-old child with a 5-year history of a resectable astrocytoma (grade II) involving the left cerebellopontine angle. Due to the clinical and radiological stability of the tumor, initial treatment included observation for up to 2 years. The disease then progressed and the patient received sequential treatment with 4 different chemotherapy lines: temozolomide, TPCV (thioguanine-procarbazine-lomustine-vincristine), vinblastine, and cisplatin-irinotecan, respectively. For 3 months, 5 months, 2 months and 4 months. On the other hand, the patient also received focal radiation therapy with a total dose of 54 Gy. In this patient, control was not achieved with these treatments, the disease progressed, and symptoms worsened. The symptoms include hiccups, dysphagia and dyslexia. The patient was treated with long-term high-dose dexamethasone to control the symptoms and developed multiple violet distended lines on his abdomen. Finally, t...

Embodiment 2

[0158]This example concerns a patient with perennial chilblain on the hands, who develops painful outbreaks and itching during the cold season. Patient seeks medical care for chilblains on hands with multiple painful, ruptured, erythematous-cyanotic lesions. Treatment with 2% diltiazem cream every 12 hours was initiated and complete resolution of lesions and general symptoms was seen after three days of treatment.

Embodiment 3

[0160] This example concerns a 3-year-old male patient with recessive dystrophic epidermolysis bullosa and chronic ulcers in the pleural area with daily pain and exudates over a year's duration. Treatment with diltiazem cream 2% every 12 hours was initiated and the patient showed good tolerance and partial response after 4 weeks of treatment.

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PUM

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Abstract

The invention relates to compositions used to relieve, improve, prevent and / or treat stretch marks and / or skin ulcers preferably of ischemic origin. The invention also relates to the composition, pharmaceutical form and uses thereof.

Description

technical field [0001] The present invention is included in the field of medicine and relates to the use of benzothiazepines, their pharmaceutically acceptable salts, solvates and hydrates in the manufacture of benzothiazepines for the treatment of stretch scars and ulcers, preferably skin ulcers, especially of ischemic origin. Use in medicinal products for ulcers. Background technique [0002] Successfully treating stretch marks (SD or stretch scars) has been a challenge. The first morphologically correct description of these lesions was made by Nardelli in 1936, when the said authors classified them as striae atrophis. The exact origin of stretch scars is still unknown, and the factors that lead to their development are still not understood. Although the cause of SD is unknown, several theories have been proposed (Elsaie et al., 2009; Dermatol Surg 35:563-573). [0003] High-resolution exoluminescence colorimetric evaluation of SD has identified four distinct types: whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/554A61P9/10
CPCA61K31/554A61P9/10A61P17/02A61K8/49A61Q19/00
Inventor 何塞·贝尔纳伯·威特尔拉奎尔·卡布雷拉·富恩特斯
Owner SERVICIO ANDALUZA DE SALU
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