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Sulfadiazine silver thermo-sensitive hydrogel and preparation method thereof

A technology of silver sulfadiazine and temperature-sensitive gel matrix, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of cytotoxicity, poor efficacy, and poor patient compliance. To reduce the pain of dressing changes, reduce the number of dressing changes, and improve compliance

Inactive Publication Date: 2019-04-12
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of sulfadiazine silver thermosensitive hydrogel and preparation method thereof, to solve the problems of existing silver sulfadiazine ointment such as poor efficacy, poor patient compliance and cytotoxicity

Method used

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  • Sulfadiazine silver thermo-sensitive hydrogel and preparation method thereof
  • Sulfadiazine silver thermo-sensitive hydrogel and preparation method thereof
  • Sulfadiazine silver thermo-sensitive hydrogel and preparation method thereof

Examples

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Embodiment 1

[0025] A sulfadiazine silver temperature-sensitive hydrogel, comprising the following raw materials in parts by mass: 3 parts of sulfadiazine silver, 6 parts of emodin, 20 parts of gelatin, 40 parts of temperature-sensitive gel matrix, 20 parts of chitosan, collagen 8 parts, temperature regulator 5 parts and humectant 10 parts. Wherein, the thermosensitive gel matrix is ​​poloxamer 407, the temperature regulator is poloxamer 188, and the moisturizing agent is glycerin.

[0026] The preparation method of the above-mentioned sulfadiazine silver temperature-sensitive hydrogel comprises the following steps:

[0027] (1) Preparation of silver sulfadiazine nanogelatin microspheres: take 10 parts of temperature-sensitive gel matrix and 1 part of temperature regulator and add it into distilled water to make a 2.5% aqueous solution, then weigh sulfadiazine silver and add it to the mixture containing temperature-sensitive gel matrix and temperature In the aqueous solution of conditione...

Embodiment 2

[0032] A sulfadiazine silver temperature-sensitive hydrogel, comprising the following raw materials in parts by mass: 1 part of sulfadiazine silver, 2 parts of emodin, 10 parts of gelatin, 22 parts of temperature-sensitive gel matrix, 10 parts of chitosan, collagen 5 parts, 1 part of temperature regulator and 20 parts of moisturizing agent. Wherein, the temperature-sensitive gel matrix is ​​poloxamer 407, the temperature regulator is carboxymethyl cellulose, and the moisturizing agent is polyethylene glycol.

[0033] The preparation method of the above-mentioned sulfadiazine silver temperature-sensitive hydrogel comprises the following steps:

[0034] (1) Preparation of silver sulfadiazine nanogelatin microspheres: take 5 parts of temperature-sensitive gel matrix and 0.5 part of temperature regulator and add them to distilled water to make a 2.5% aqueous solution, then weigh sulfadiazine silver and join the mixture containing temperature-sensitive gel matrix and temperature I...

Embodiment 3

[0039] A sulfadiazine silver temperature-sensitive hydrogel, comprising the following raw materials in parts by mass: 2 parts of sulfadiazine silver, 5 parts of emodin, 16 parts of gelatin, 30 parts of temperature-sensitive gel matrix, 15 parts of chitosan, collagen 10 parts, temperature regulator 3 parts and humectant 15 parts. Wherein, the temperature-sensitive gel matrix is ​​poloxamer 407, the temperature regulator is polyvinyl alcohol, and the moisturizing agent is 10 parts of glycerol and 5 parts of polyethylene glycol.

[0040] The preparation method of the above-mentioned sulfadiazine silver temperature-sensitive hydrogel comprises the following steps:

[0041] (1) Preparation of silver sulfadiazine nanogelatin microspheres: take 10 parts of temperature-sensitive gel matrix and 1 part of temperature regulator and add it into distilled water to make a 2.5% aqueous solution, then weigh sulfadiazine silver and add it to the mixture containing temperature-sensitive gel mat...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a sulfadiazine silver thermo-sensitive hydrogel and a preparation method thereof. The hydrogel includes sulfadiazine silver, gelatin, a thermo-sensitive gel matrix, emodin, chitosan, collagen, a temperature regulator, and a humectant. The sulfadiazine silver is micronized to enlarge the surfacearea of particles so as to enhance the antibacterial effect. The method uses the sulfadiazine silver and the emodin as main drugs, the gelatin as a carrier, then uses the thermo-sensitive gel matrix,the temperature regulator, the chitosan and the collagen to prepare a thermo-sensitive hydrogel substrate, and finally encapsulates the sulfadiazine silver and the emodin in the hydrogel substrate soas to form the new sulfadiazine silver thermo-sensitive hydrogel. The hydrogel is an aqueous gel preparation which can be applied to burn and scald wound infection, and has good antibacterial effect,high efficiency and low toxicity, and high compliance for patients.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically discloses a sulfadiazine silver temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Silver sulfadiazine is a sulfonamide / silver salt antibacterial drug. It is a white or off-white crystalline powder. It is used to treat burn and scald wound infection. In addition to controlling infection, it can also promote wound drying, scab formation and healing. Currently commercially available silver sulfadiazine is mostly ointment, which is applied to the affected area during use. The concentration of silver sulfadiazine is 1.0%. To increase the blood concentration of the drug, it is necessary to increase the number of administrations (2 to 4 times a day), but multiple administrations will cause the accumulation of silver ions, which will cause problems such as vascular toxicity, keratinocyte and fibroblast toxicity. At the sam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/06A61K47/42A61K47/36A61K47/10A61K47/38A61K47/32A61P31/04A61P17/02A61K33/38A61K31/635A61K31/122A61K31/722
CPCA61K9/0014A61K9/06A61K31/122A61K31/635A61K31/722A61K33/38A61K38/39A61K47/10A61K47/32A61K47/36A61K47/38A61K47/42A61P17/02A61P31/04A61K2300/00
Inventor 向小洪林凤云谢阳刘巧
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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