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Surface modification method of flexible stretchable circuit and application thereof

A surface modification and flexible technology, applied in photolithography/patterning, patterning and photolithography, pattern formation by transfer, etc., can solve problems such as damage, failure to provide sufficient biocompatibility, and failure to function normally

Active Publication Date: 2019-01-29
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is that the existing flexible circuits, especially those that are in direct contact with cells or tissues, cannot provide good enough biocompatibility (cells / tissues), resulting in abnormalities due to the deterioration of the local environment after implantation. function or cause performance damage to the original function

Method used

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  • Surface modification method of flexible stretchable circuit and application thereof
  • Surface modification method of flexible stretchable circuit and application thereof
  • Surface modification method of flexible stretchable circuit and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] This example is used to illustrate the flexible and stretchable conductive circuit prepared by the method of the present invention.

[0086] Put 1g of liquid indium gallium eutectic alloy (EGaIn Ga 75.5%wt In 24.5%wt) in 1ml of mixed solution of n-octanol and glycerol (volume ratio octanol: glycerol=80:20), use Ultrasonic cell disruptor ultrasonicated at 30% amplitude for 60s to obtain a gray liquid metal suspension. The metal was dispersed into numerous micro-nano sized particles with an average particle size of 1500nm. The core of the small particles is liquid metal, and the outside is covered by a thin oxide film. In order to achieve complete transfer, the PET film was selected as the original pattern layer, and the PDMS solution was prepared according to the ratio of PDMS prepolymer: curing agent mass ratio of 10:1. A line width of 500 μm was produced on PET film using screen printing technology ( Figure 5 ) electrode pattern, and its width was measured with a hi...

Embodiment 2

[0088]This example is used to illustrate the flexible and stretchable conductive circuit prepared by the method of the present invention.

[0089] Put 1g of liquid indium gallium eutectic alloy (EGaIn Ga 75.5%wt In 24.5%wt) in 1ml of mixed solution of n-octanol and glycerol (volume ratio octanol: glycerol=80:20), use Ultrasonic cell breaker ultrasonicated at 30% amplitude for 20 minutes to obtain a gray liquid metal suspension. The metal was dispersed into numerous micro-nano-sized small particles, and the average particle size of the small particles was 800nm. The core of the small particles is liquid metal, and the outside is covered by a thin oxide film. In order to achieve complete transfer, the PET film was selected as the original pattern layer, and the PDMS solution was prepared according to the ratio of PDMS prepolymer: curing agent mass ratio of 10:1. A line width of 200 μm was fabricated on PET film using screen printing technology ( Image 6 ) electrode pattern, a...

Embodiment 3

[0091] This example serves to illustrate the direct surface modification of flexible and stretchable conductive circuits using the method of the present invention.

[0092] Using microfluidic technology, according to different circuit patterns, design microfluidic chips suitable for the shape of the circuit ( figure 2 ), add 1ml of Fibronectin solution with a concentration of 1mg / ml to the chip, cover the surface of the stretched line, incubate in the incubator at 37°C for 4 hours, take it out, and wash it gently once with PBS solution with a pH of 7.4. directly used to grow cells. The surface-modified stretched conductive circuit exhibits good biocompatibility, cells can adhere well to its surface, and maintain good activity after 7 days of culture ( image 3 ).

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Abstract

The invention provides a surface modification method of a flexible stretchable circuit and an application thereof. According to the method, the cell compatibility and tissue compatibility of the conductive circuit and the circuit stability of the conductive circuit when being directly contacted with cells / tissues can be obviously improved, and the conductivity can still be well maintained after long-term co-culture or implantation in vivo; and the Faraday cage effect caused by a surface oxide layer is overcome, a stable electric field can be generated by serving as an electrode, and the functionality of conductive circuit is improved. The method is simple and convenient in step, easy to operate, capable of performing surface treatment without a need of special instruments and used for preparing functional flexible circuits in a large scale; the flexible stretchable circuit subjected to direct surface modification or multiple surface modification can be widely applied to a conductive circuit which is directly contacted or indirectly contacted with cells or tissues and applied to the fields such as tissue engineering, biosensors and photoelectric materials; and the method can quicklyrealize industrial large-scale preparation and applied to the fields such as wearable electronic equipment and implantation medical instruments.

Description

technical field [0001] The invention belongs to the field of electronic circuits, and in particular relates to a method for modifying the surface of a flexible and stretchable circuit and its application. Background technique [0002] With the development of biotechnology, wearable devices and implantable flexible electronic devices have been greatly developed, but wearable or implantable devices that are actually used in the human body are subject to great technical limitations. The reason is that the existing flexible circuits, especially those that are in direct contact with cells or tissues, cannot provide good enough biocompatibility (cells / tissues), resulting in abnormalities due to the deterioration of the local environment after implantation. function or cause performance damage to the original function. [0003] We propose a preparation method and application of a flexible and stretchable circuit and circuit. The essence of this method is a simple, convenient and ...

Claims

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Application Information

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IPC IPC(8): H05K3/10
CPCH05K3/10H05K2203/0528
Inventor 蒋兴宇成诗宇唐立雪
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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