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Collagen film for auxiliary treatment of peripheral nerve injury and its preparation method and application

A technology for peripheral nerve injury and collagen film, which is applied in the field of medical devices, can solve the problems of tension in peripheral nerve stumps and unfavorable nerve repair, and achieve better results and promote recovery

Active Publication Date: 2022-02-01
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problem that classic epineurium and perineurium sutures cause tension on the stumps of peripheral nerves, which is not conducive to nerve repair, and assist peripheral nerve fusion agents to overcome the need for peripheral nerve damage in the prior art. The disadvantage of nerve cell regeneration is to shift the center of treatment to the early stage of injury, repair damaged nerve fiber bundles through peripheral nerve fusion, restore the structural integrity and electrical conduction function of nerve cells, and restore nerve function as quickly as possible in the early stage of injury

Method used

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  • Collagen film for auxiliary treatment of peripheral nerve injury and its preparation method and application
  • Collagen film for auxiliary treatment of peripheral nerve injury and its preparation method and application
  • Collagen film for auxiliary treatment of peripheral nerve injury and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Collagen Film for Adjuvant Treatment of Peripheral Nerve Injury

[0036] 1. Solution preparation

[0037] 1w / w% collagen aqueous solution: Weigh 1g of soluble collagen powder and dissolve it in 99ml of distilled water.

[0038] Dilute acetic acid solution of chitosan with a concentration of 2w / w%: Weigh 1.0g of glacial acetic acid and dissolve it in 99ml of distilled water to obtain a dilute acetic acid solution with a concentration of 1w / w%; weigh 1.0g of chitosan and dissolve it in 49.0ml to prepare Dilute acetic acid solution, that is.

[0039] 5w / w% polyvinyl alcohol aqueous solution: weigh 5g of polyvinyl alcohol and dissolve it in 95ml of distilled water.

[0040] 0.000001w / w% aqueous solution of nerve growth factor: Weigh 0.01g of nerve growth factor and dissolve in 100ml of distilled water to obtain a 0.01w / w% aqueous solution of nerve growth factor, then dilute to 0.000001w / w% concentration.

[0041] B12 aqueous solution with a conce...

Embodiment 2

[0048] Example 2 Preparation of Collagen Membrane for Adjuvant Treatment of Peripheral Nerve Injury

[0049] 1. Preparation of solution

[0050] Same as Example 1.

[0051] 2. Preparation of collagen membranes

[0052] (1) each raw material is weighed according to the following percentage by weight:

[0053] 1w / w% concentration of collagen aqueous solution 41%, 2w / w% concentration of chitosan in dilute acetic acid solution 15%, 5w / w% concentration of polyvinyl alcohol aqueous solution 20%, 0.000001w / w% concentration of nerve growth Factor aqueous solution 10%, B12 aqueous solution 10w / w% concentration 7%, polyethylene glycol 4% and glutaraldehyde aqueous solution 0.25w / w% concentration 3%;

[0054] (2) The collagen aqueous solution, the dilute acetic acid solution of chitosan, the polyvinyl alcohol aqueous solution, the nerve growth factor aqueous solution, the B12 aqueous solution and the polyethylene glycol are blended, fully stirred, and allowed to stand at room temperat...

Embodiment 3

[0056] Example 3 Preparation of Collagen Membrane for Adjuvant Treatment of Peripheral Nerve Injury

[0057] 1. Preparation of solution

[0058] Same as Example 1.

[0059] 2. Preparation of collagen membranes

[0060] (1) each raw material is weighed according to the following percentage by weight:

[0061] 1w / w% concentration of collagen aqueous solution 48%, 2w / w% concentration of chitosan in dilute acetic acid solution 8%, 5w / w% concentration of polyvinyl alcohol aqueous solution 24%, 0.000001w / w% concentration of nerve growth Factor aqueous solution 8%, B12 aqueous solution 10w / w% concentration 5%, polyethylene glycol 600 5% and glutaraldehyde aqueous solution 0.25w / w% concentration 2%;

[0062] (2) The collagen aqueous solution, the dilute acetic acid solution of chitosan, the polyvinyl alcohol aqueous solution, the nerve growth factor aqueous solution, the B12 aqueous solution and the polyethylene glycol are blended, fully stirred, and allowed to stand at room temper...

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Abstract

The invention discloses a collagen film for auxiliary treatment of peripheral nerve injury, a preparation method and application thereof. The collagen film is obtained by cross-linking collagen aqueous solution, chitosan dilute acetic acid solution, polyvinyl alcohol aqueous solution, nerve growth factor aqueous solution, B12 aqueous solution and polyethylene glycol through glutaraldehyde crosslinking. At present, the treatment of peripheral nerves is limited to the auxiliary support of neurotrophic drugs after microsurgical suture. This method will generate a certain tension on the stumps of peripheral nerves, which is not conducive to the repair of stumps. The present invention can overcome the problem of tension generated at the stumps of peripheral nerves and the degradation of the collagen membrane in the early stage of recovery can promote the recovery of peripheral nerves, and can restore their basic motor functions in a short time Membrane suture or end perineurium epineurium suture combined with nerve fusion agent is more effective.

Description

technical field [0001] The present invention relates to a collagen film for auxiliary treatment of peripheral nerve injury and its preparation method and application, in particular to a collagen film for auxiliary nerve fusion agent treatment of peripheral nerve injury and its preparation method and application. The invention belongs to the technical field of medical instruments. Background technique [0002] The current study believes that after nerve injury, the axon and myelin sheath of the nerve fibers at the distal end of the injury plane are destroyed, the connection dispute between the innervated target organ and neurons, and the entire nerve pathway collapses. This series of reactions is called This is called Wallerian degeneration. Early after injury, the activation and release of proteases in nerve cell somata degenerates the distal parts of the nerve. As the cell membrane dissolves, the cytoskeleton begins to disintegrate. The proximal nerve becomes edematous d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K9/70A61P25/02A61K38/18A61K35/28A61K35/545A61K36/537A61K35/30A61K33/44A61K31/765
CPCA61K38/185A61K38/39A61K47/42A61P25/02A61K9/7007A61K31/765A61K33/44A61K35/28A61K35/30A61K35/545A61K36/537A61K2300/00
Inventor 任晓平任帅
Owner HARBIN MEDICAL UNIVERSITY
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