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Chinese herba preparation for promoting blood circulation and stopping pain and preparation method thereof

A traditional Chinese medicine preparation, a technology for promoting blood circulation and relieving pain, which is applied in the directions of non-central analgesics, pharmaceutical formulations, and non-active ingredients medical preparations, etc. Convenience, high effective utilization, and the effect of reducing the recurrence of medication

Inactive Publication Date: 2018-12-07
荆州市致强生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to aim at the problems of the prior art in the treatment of intervertebral disc herniation, rheumatoid arthritis, rheumatoid arthritis and bruises, repeated attacks, long treatment period, unsatisfactory effect, and inconvenience to patients, and provide A formula based on traditional Chinese medicine theory using hirudin, using modern advanced preparation methods to make gels or patches, directly administering treatment to the affected part, using hirudin to stabilize, and high transdermal absorption rate The traditional Chinese medicine preparation and preparation method for promoting blood circulation and relieving pain with short treatment cycle, convenient use, small side effects and high bioavailability

Method used

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  • Chinese herba preparation for promoting blood circulation and stopping pain and preparation method thereof
  • Chinese herba preparation for promoting blood circulation and stopping pain and preparation method thereof
  • Chinese herba preparation for promoting blood circulation and stopping pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment a

[0048] Embodiment a: Get 6 parts of hirudin, 0.1 part of musk, 2 parts of borneol, 1.0 part of menthol, 9400.2 parts of carbomer, 1.3 parts of triethanolamine, 0.2 part of methylparaben, 10.0 parts of PEG-400, purified water 76 parts, 0.5 part of laurocaprazine, 0.684 part of sodium chloride; first sodium chloride is dissolved in the water of recipe quantity and makes physiological saline, adds hirudin superfine powder and stirs for 30 minutes, adds Carbomer 940 and fully dissolves and statically Leave it for 12 hours, then mix musk, borneol, and menthol into fine powder, pour it into the hirudin solution, add methylparaben, PEG-400, and laurocaprazine and stir evenly, and use triethanolamine to regulate pH value, if the pH value reaches 6.3-6.8, send the evenly stirred material into the filling machine for filling with plastic hose or aluminum tube, 20g each, sterilize and store at room temperature.

Embodiment b

[0049] Example b: Take 60 parts of hirudin, 1 part of musk, 20 parts of borneol, 10 parts of menthol, 9402 parts of carbomer, 13 parts of triethanolamine, 2 parts of methylparaben, 100 parts of PEG-400, purified water 760 parts, 5 parts of laurocaprazine, 6.84 parts of sodium chloride; First sodium chloride is dissolved in the water of recipe quantity and makes physiological saline, adds hirudin superfine powder and stirs for 30 minutes, adds Carbomer 940 and fully dissolves and statically Leave it for 12 hours, then mix musk, borneol, and menthol into fine powder, pour it into the hirudin solution, add methylparaben, PEG-400, and laurocaprazine and stir evenly, and use triethanolamine to regulate pH value, if the pH value reaches 6.3-6.8, send the evenly stirred material into the filling machine for filling with plastic hose or aluminum tube, 20g each, sterilize and store at room temperature.

Embodiment c

[0050] Embodiment c: get 120 parts of hirudin, 20 parts of musk, 400 parts of borneol, 200 parts of menthol, 94040 parts of carbomer, 260 parts of triethanolamine, 40 parts of methylparaben, 2000 parts of PEG-400, purified water 15200 parts, 100 parts of laurocaprazine, 136.8 parts of sodium chloride; first sodium chloride is dissolved in the water of prescription quantity and makes physiological saline, adds hirudin superfine powder and stirs for 30 minutes, adds carbomer 940 and fully dissolves and statically Leave it for 12 hours, then mix musk, borneol, and menthol into fine powder, pour it into the hirudin solution, add methylparaben, PEG-400, and laurocaprazine and stir evenly, and use triethanolamine to regulate pH value, if the pH value reaches 6.3-6.8, send the evenly stirred material into the filling machine for filling with plastic hose or aluminum tube, 20g each, sterilize and store at room temperature.

[0051] 2. Made into a patch:

[0052] Embodiment a: Get 6 p...

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Abstract

The invention relates to a Chinese herba preparation for promoting blood circulation and stopping pain and a preparation method thereof and belongs to the technical field of biological traditional Chinese medicine preparation. A gel or paste is prepared by taking hirudin as a sovereign drug, borneol as an adjuvant, mint as a conductant drug, Carbomer 940 and polyethylene glycol 400 as gel substances, triethanolamine for regulating pH value, methylparaben as a preservative and laurocapram as a penetration enhancer. According to the invention, a hirudin extractive is acquired in the manner of low temperature extracting-freeze drying; the damage of a high temperature to the medicinal activity of leech is avoided in the whole process; the digesting and clinical effects of leech are promoted through superfine grinding and normal saline dissolution technologies. In the invention, the theory of traditional Chinese medicine and the viewpoints of modern medicine are combined, the hirudin is used as a medicine and the recovery of physiological structure of the affected part is boosted by starting from improving blood circulation of focus for the symptoms of protrusion of intervertebral disc,rheumatic arthritis, traumatic injury, and the like, so that the purposes of addressing both symptoms and root causes and reducing drugs used for relapse can be achieved. The Chinese herba preparation has the characteristics of small side effects, use safety and dosing convenience.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for promoting blood circulation and relieving pain and a preparation method thereof, belonging to the technical field of biological traditional Chinese medicine preparation. Background technique [0002] Herniated intervertebral disc is one of the more common diseases, with the highest incidence rate between 30 and 50 years old, and the incidence of patients tends to be younger in recent years. Herniated intervertebral disc is divided into lumbar disc herniation and cervical intervertebral disc herniation, manifested as various parts of the intervertebral disc (nucleus pulposus, annulus fibrosus, and cartilage plate); especially the nucleus pulposus, after varying degrees of degenerative changes, under the action of external force factors, the intervertebral disc The annulus fibrosus ruptures, and the nucleus pulposus tissue protrudes (or protrudes) from the rupture to the rear or in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/58A61K9/06A61K9/70A61P29/00A61P19/08A61P19/02A61K35/55A61K31/045
CPCA61K9/0014A61K9/06A61K9/7023A61K31/045A61K35/55A61K38/58A61K47/32A61P19/02A61P19/08A61P29/00A61K2300/00
Inventor 徐伟余涛丁钊龚元
Owner 荆州市致强生物科技有限公司
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