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Application of magnetic induction protein to improvement of neurodegenerative diseases

A neurodegenerative, magnetic induction technology, applied in the field of magnetogenetics, which can solve the problems of limited curative effect and irreversible disease

Active Publication Date: 2018-11-23
HEYE HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, the treatment of neurodegenerative diseases is mainly to delay the development of the disease and cannot reverse the disease, and the curative effect is very limited
And given the diversity of causative factors in neurodegenerative diseases, blockade of one or both pathways does not significantly reduce overall neuronal dysfunction and loss

Method used

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  • Application of magnetic induction protein to improvement of neurodegenerative diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Parkinson's disease (PD) is one of the degenerative diseases of the nervous system that seriously affects the quality of life and physical and mental health of middle-aged and elderly people. It is a common senile central nervous system degenerative disease with quality deficiency as the main pathological basis, which has the characteristics of high incidence and insidious onset. In recent years, studies have found that Parkinson-related proteins α-synuclein (α-synuclein), glycogen synthase kinase-3β (GSK-3β), and Tau protein have important roles in the pathogenesis and development of PD and the protection of dopamine neurons. Regulatory effect.

[0043] 1. Experimental steps

[0044] (1)MPP + modeling

[0045] Taking dopaminergic nerve cell MES23.5 cells as the research object, 1-methyl-4-phenylpyridinium ion (1-methyl-4-phenyl-pyridinium, MPP + ) to establish an in vitro cell injury model of PD.

[0046] MES23.5 cells were inoculated in 5% (volume fraction) fetal...

Embodiment 2

[0065] Alzheimer's disease (AD) is a progressive neurodegenerative disease, clinically manifested as memory and cognitive dysfunction, loss of language and behavioral abilities, and severe amnesia and Motor function is impaired, eventually leading to death. The current study found that the deposition of β-amyloid protein (Aβ) in the brain is the main pathological cause of AD, the apoptosis of hippocampus is closely related to the neurotoxicity of Aβ, and the gene regulation of Bcl-2 and Bax in apoptosis play a vital role in the process.

[0066] 1. Experimental steps

[0067] (1) Screening of experimental animals

[0068] The Morris water maze was used to train 50 SD rats, once a day in the morning and at the same time in the afternoon, for 4 consecutive days. In the third quadrant of the Morris water maze, a submerged platform (1 cm below the water surface) was set, and the rats entered the water at the 1 / 2 arc of the edge of the four quadrants, and the time for the rats t...

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Abstract

The invention relates to the field of magnetic genetics, and particularly relates to application of magnetic induction protein to improvement of neurodegenerative diseases. According to the application of magnetic induction protein to improvement of the neurodegenerative diseases disclosed by the invention, an experiment proves that the magnetic induction protein is imported into PD cells so thata result shows that a survival ratio of the PD cells is increased under the effect of a magnetic field, and alpha-synuclein and GSK-3beta levels in the PD cells are reduced; the magnetic induction protein is imported into an AD rat model; under the effect of the magnetic field, Bcl-2 expression of AD-model rat hippocampus CA1 area is increased, and Bax protein expression is reduced, and the learning and memory abilities of the rats are improved; therefore, the magnetic induction protein has the effects of improving the neurodegenerative diseases. The invention also provides the medicine for improving the neurodegenerative diseases, and the medicines comprise magnetic induction protein or gene engineering carriers for expressing the magnetic induction protein.

Description

technical field [0001] The invention relates to the field of magnetogenetics, in particular to the application of magnetoreceptor proteins in improving neurodegenerative diseases. Background technique [0002] Neurodegenerative disease (Neurodegenerative disease, ND) is a kind of chronic, progressive neurological disease. Although the lesion sites and causes of different types of neurodegenerative diseases are different, delayed neurodegeneration and cell loss in specific areas of the brain are their common features, so they are collectively referred to as neurodegenerative diseases. [0003] Neurodegenerative diseases mainly include: senile dementia (Alzheimer's disease, AD, Alzheimer's disease); Parkinson's disease (Parkinson's disease, PD), Huntington's disease (Huntington's disease, HD), spinocerebellar ataxia ( spinal cerbellar ataxias), denatatorubropallidoluydian atrophy, amyotrophic lateral sclerosis (Amyotrophic Lateral Sclerosis, ALS), spinal muscular atrophy (Spi...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K38/16A61K48/00A61K9/00A61P25/28A61P25/16A61P25/14A61P25/00
CPCA61K9/0009A61K9/0019A61K38/16A61K45/00A61K48/0008
Inventor 方志财胡立江方彦雯刘萌雨
Owner HEYE HEALTH TECH CO LTD
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