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Multifunctional cardiovascular coating material with super-hydraulic performance and preparation method thereof

A coating material and multi-functional technology, applied in coatings, catheters, medical science, etc., can solve problems such as adverse effects of implant materials in service, causing acute inflammatory response, etc., to inhibit the growth of bacteria, promote growth, and prevent adhesion. echo the effect of activation

Active Publication Date: 2018-11-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At the same time, the implantation of the material will cause an acute inflammatory reaction, and the non-specific adsorption of proteins on the surface of the implant in the human body will make the implant recognized by the macrophages in the immune system, and the macrophages will pass through the body if the phagocytosis fails. Self-fusion to form giant cells and secrete cytokines (peak within 24 hours), prompting fibroblasts to deposit on the surface of the implant and eventually form a dense fibrous capsule and cover the implant, thereby serving the implant material bring adverse effects

Method used

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  • Multifunctional cardiovascular coating material with super-hydraulic performance and preparation method thereof
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Examples

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Embodiment 1

[0034] A preparation method of a multifunctional cardiovascular coating material with superhydrophilic properties, comprising the following steps:

[0035] (1) Polish the medical stainless steel that needs to be modified, and then clean and dry;

[0036] (2) Place the treated stainless steel in an acetic acid-acetate buffer solution with a pH value of 4, then add gallic acid with a final concentration of 0.01 mg / mL and gallic acid with a final concentration of 0.01 mg / mL in the buffer system successively. Dopamine was reacted at 40°C for 2h; then sodium periodate solution with a final concentration of 0.01mg / ml was added, and reacted at 40°C for 30h;

[0037] (3) Use deionized water to ultrasonically clean the product obtained in step (2) for 3 times, each time for 5 minutes, and then dry it under nitrogen to prepare a super-hydrophilic, anti-coagulant, anti-inflammatory and anti-inflammatory product. Oxidation, avoidance of endothelial cell apoptosis, inhibition of smooth musc...

Embodiment 2

[0039] A preparation method of a multifunctional cardiovascular coating material with superhydrophilic properties, comprising the following steps:

[0040] (1) Polish the nickel-titanium alloy that needs to be modified, and then clean and dry;

[0041] (2) Place the treated stainless steel in a phthalic acid-hydrochloric acid buffer solution with a pH value of 3.5, and then add epigallocatechin gallate (EGCG) with a final concentration of 1 mg / mL in the buffer system, Dopamine with a final concentration of 2mg / mL was reacted at 30°C for 2h; then sodium periodate solution with a final concentration of 2mg / mL was added and reacted at 30°C for 10h;

[0042] (3) Wash the product obtained in step (2) with deionized water for 3 times, each time for 5 minutes, and then dry it under nitrogen to prepare a super-hydrophilic, anti-coagulant, anti-inflammatory, and anti-oxidative product , Avoid endothelial cell apoptosis, inhibit smooth muscle cell proliferation multifunctional cardiova...

Embodiment 3

[0044] A preparation method of a multifunctional cardiovascular coating material with superhydrophilic properties, comprising the following steps:

[0045] (1) cleaning and drying the polytetrafluoroethylene that needs to be modified;

[0046] (2) Place the treated stainless steel in 2-(N-morpholine) ethanesulfonic acid buffer solution with a pH value of 6, and then add epicatechin gallic acid with a final concentration of 2 mg / mL in the buffer system Ester (ECG) and dopamine with a final concentration of 4mg / mL were reacted at 15°C for 2h; then sodium periodate solution with a final concentration of 4mg / mL was added and reacted at 15°C for 24h;

[0047] (3) Wash the product obtained in step (2) with deionized water for 3 times, each time for 5 minutes, and then dry it under nitrogen to prepare a super-hydrophilic, anti-coagulant, anti-inflammatory, and anti-oxidative product , Avoid endothelial cell apoptosis, inhibit smooth muscle cell proliferation multifunctional cardiova...

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Abstract

The invention discloses a multifunctional cardiovascular coating material with super-hydraulic performance and a preparation method thereof. The method comprises the following steps that (1) a substrate material is subjected to pretreatment; (2) the pretreated substrate material is put into a buffer system; then, a polyphenol compound and dopamine are added; reaction is performed for 2h at 4 to 50DEG C; then, sodium periodate is added; reaction is performed at 4 to 50 DEG C; (3) the product obtained in the step (2) is subjected to ultrasonic cleaning by deionized water for 3 to 5 times; nitrogen gas is used for drying; the multifunctional cardiovascular coating material is obtained. A prepared multifunctional cardiovascular coating has good stability, excellent hydrophilicity, good anticoagulant performance, good anti-inflammatory performance and good antioxidation performance; the endothelial cell apoptosis is avoided; the capability of inhibiting the smooth muscle cell multiplication is realized; the multifunctional cardiovascular coating material can be used for preparation of blood contact type materials such as intravascular stents, cardiac valves, artificial blood vessels and blood contact catheters in the field of medical materials.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a multifunctional cardiovascular coating material with superhydrophilic performance and a preparation method thereof. Preparation of contact materials. Background technique [0002] Having excellent blood compatibility and cell compatibility is one of the conditions that biological materials must meet, especially for cardiovascular materials that are in direct contact with blood (such as: vascular stents, heart valves, artificial blood vessels, pacemakers, artificial Blood vessels, blood contact catheters, etc.), excellent blood compatibility is the primary consideration. After the material comes into contact with blood, the adsorption and denaturation of plasma proteins (such as fibrinogen, etc.) occurs in a very short period of time, followed by the adhesion, activation and aggregation of platelets, the formation of fibrin network, and finally the formati...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/28A61L27/54A61L29/08A61L29/16A61L29/14A61L31/14A61L31/16A61L31/08
CPCA61L27/28A61L27/50A61L27/507A61L27/54A61L29/08A61L29/14A61L29/16A61L31/08A61L31/14A61L31/16A61L2300/216A61L2300/404A61L2300/41A61L2300/412A61L2300/42A61L2300/606A61L2430/20A61L2430/22
Inventor 王云兵李林华罗日方杨立庄伟华
Owner SICHUAN UNIV
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