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Preparation method of naringin dihydrochlcone

A technology for naringin dihydrochalcone and naringin, which is applied in the field of biological separation and chemical synthesis, can solve the problems of insufficiency, the influence of purifying naringin, and the long process flow, and achieves reduction of mass transfer and heat transfer. resistance, accelerated solvation effect, effect of increasing diffusion coefficient

Active Publication Date: 2018-11-06
HUNAN AGRI PRODS PROCESSING INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a large amount of organic solvents such as methyl alcohol, chloroform, sherwood oil, n-butanol, n-hexane and strong acid and strong alkali reagents have been used in the above extraction process, and the extraction cost is high, and the use of these organic solvents will produce a large amount of waste water, which increases the Difficulty and cost of processing, large environmental pollution, long process flow, complicated operation, long time-consuming, high extraction cost, high solvent residue, etc. The existence of these problems makes these processes unable to meet the requirements of using naringin to prepare naringin. The actual demand of dihydrochalcone limits the industrial production of naringin dihydrochalcone
In addition, because citrus peel and Fructus Aurantii contain pigments and lipid compounds, the existing extraction methods will dissolve these impurities together with naringin, which has a great impact on the purification of naringin, which is not conducive to obtaining high yield and Purity of Naringin Dihydrochalcone

Method used

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  • Preparation method of naringin dihydrochlcone

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A kind of preparation method of naringin dihydrochalcone, process flow chart is as follows figure 1 shown, including the following steps:

[0034] (1) Drying and ultrafinely pulverizing the orange peel to obtain citrus peel powder, wherein the particle size of the citrus peel powder is 20 μm.

[0035] (2) Put the citrus peel powder obtained in step (1) into a subcritical extraction kettle, feed high-purity nitrogen, and simultaneously add Deoxygenated distilled water (in this embodiment, deoxygenated distilled water is obtained by injecting high-purity nitrogen gas into the distilled water to remove residual oxygen), the pressure is 6MPa, the temperature is 250 ℃ for the first subcritical water extraction for 60min, cooling , pressure filtration, and discard the filtrate obtained by pressure filtration to obtain a filter residue, which continues to be used for subcritical water extraction.

[0036] (3) According to the mass ratio of gac and filter residue is 5%, the f...

Embodiment 2

[0047] Investigate the effect of different macroporous resins on the extraction effect of naringin:

[0048] Take D101 macroporous resin, D4020 macroporous resin, AB-8 macroporous resin, D130 macroporous resin, HPD450 macroporous resin and D140 macroporous resin, each 2.0g, respectively added to 30mL of Example 1 In the supernatant liquid obtained in step (3), after standing at room temperature and fully adsorbing to reach saturation (24h), filter, measure the content of naringin in the sample liquid before and after adsorption and elute with ethanol solution with a volume concentration of 90% The content of naringin in the back eluent, the results are shown in table 2. Table 2 shows the comparative results of the adsorption capacity and resolution capacity of different macroporous resins.

[0049] Calculate the adsorption rate and desorption rate of limonin by the macroporous resin according to the following formula.

[0050] Adsorption rate (%) = (C 0 -C 1 ) / C 0 ×100

...

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Abstract

The invention discloses a preparation method of naringin dihydrochlcone. The preparation method of the naringin dihydrochlcone comprises the following steps: drying and superfinely grinding a citrus peel and / or fructus aurantii immaturus; conducting subcritical water extraction on a citrus peel powder; purifying and eluting a naringin extracting solution; concentrating a naringin eluant at the reduced pressure, freeze-drying; conducting hydrogenation on the naringin; regulating the pH value of a hydrogenation solution, allowing standing still, filtering, and freeze-drying, thereby obtaining the naringin dihydrochlcone. The preparation method has the advantages of being simple in process, convenient to operate, low in cost, green, and high in yield and purity, the comprehensive utilizationvalue of the citrus and fructus aurantii immaturus is improved, and the preparation method has an excellent application prospect and an excellent economic benefit; in addition, no organic solvent is used in the preparation process, no secondary pollution is caused to the environment, and the preparation method is a promising environmentally friendly preparation method, is suitable for large-scalepreparation, and can be industrially used conveniently.

Description

technical field [0001] The invention belongs to the technical field of biological separation and chemical synthesis, and relates to a process for extracting and synthesizing effective components of citrus, in particular to a method for preparing naringin dihydrochalcone. Background technique [0002] Naringin Dihydrochalcone (Naringin Dihydrochalcone) is a sweetener that has attracted widespread attention. Its sweetness is about 1000 times that of sucrose. Naringin dihydrochalcone is especially suitable as an additive to dairy products, fats and oils, frozen foods, processed vegetables, jellies, jams, non-alcoholic beverages, chewing gum, toothpaste and buccal tablets. As a substitute for sugar, naringin dihydrochalcone can also reduce the intake of sugar by the human body, which is undoubtedly a boon for preventing obesity and patients who are not suitable for sugar consumption. However, naringin dihydrochalcone cannot be obtained directly from nature and needs to be made ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08C07H1/00
CPCC07H1/00C07H1/08C07H15/203
Inventor 单杨梁曾恩妮郭佳婧李高阳肖业成苏瑾潘兆平
Owner HUNAN AGRI PRODS PROCESSING INST
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