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Senecio cineraria total flavonoid extract as well as preparation method and application of extract in cosmetics thereof

A technology of total flavonoids and extracts, applied in the application field of sunscreen and whitening cosmetics, can solve the problem of efficacy evaluation and product development reports of total flavonoids of snow chrysanthemum for whitening and sun protection, lack of standardized production and detection system of total flavonoids of snow chrysanthemum , Limit the in-depth development and market application of Xueju, and achieve the effects of broad market application prospects, good tyrosinase activity, and low production costs

Active Publication Date: 2018-10-26
广州华玺生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application and development of the total flavonoids extract of snow chrysanthemum in cosmetics is in its infancy. The extraction, preparation and purification technology of the total flavonoids of snow chrysanthemum is not perfect, and there is a lack of a standardized production and detection system for comprehensive and effective control of the quality of the total flavonoids of snow chrysanthemum. The efficacy evaluation and product development reports of total flavonoids of chrysanthemum on whitening and sun protection limit the in-depth development and market application of snow chrysanthemum in the cosmetics industry

Method used

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  • Senecio cineraria total flavonoid extract as well as preparation method and application of extract in cosmetics thereof
  • Senecio cineraria total flavonoid extract as well as preparation method and application of extract in cosmetics thereof
  • Senecio cineraria total flavonoid extract as well as preparation method and application of extract in cosmetics thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the preparation method of snow chrysanthemum total flavonoids extract, the steps are as follows:

[0034] (1) Single factor investigation of the total flavonoids extract of Snow Chrysanthemum

[0035] After crushing the dried flocculus of snow chrysanthemum, accurately weigh several dried samples of snow chrysanthemum, 0.5g each, and place them in a 50mL round-bottomed flask to investigate the ethanol concentration, extraction temperature, extraction time, and liquid-to-material ratio for flavonoid yield effect, see the specific results figure 1 .

[0036] Investigation of the influence of ethanol concentration on the extraction efficiency of total flavonoids of chrysanthemum: Take 3 parts of sample powder, add water, 30%, 50%, 70% and 95% ethanol 10mL respectively, heat and extract at 60°C for 60min, filter while hot, and use Dilute the corresponding concentration of ethanol to 100mL, measure the total flavonoid content, see the results figure 1 a. Th...

Embodiment 2

[0052] Embodiment 2: Quality detection of snow chrysanthemum total flavonoids extract

[0053] (1) Fingerprint

[0054] Accurately weigh 50 mg of the extract powder dried to constant weight, place it in a 5 mL volumetric flask, add ultrapure water to dissolve it, and adjust the volume to the mark to make a 10 mg / mL solution. Take the supernatant and pass through a 0.22 μm microporous filter. After the film, take the filtrate and put it on a high-performance liquid chromatograph for detection, wherein the mobile phase A is an aqueous solution of glacial acetic acid at pH=2.5, and the mobile phase B is acetonitrile; the chromatographic column is AglientPoroshell 120EC-C18 (4.6*100mm, 2.7 μm); chromatographic conditions The flow rate is 1.0mL / min, the wavelength is 280nm, the column temperature is 35°C, the injection volume is 10μL, and chlorogenic acid is used as the reference substance.

[0055] The chromatographic results of the total flavonoids extract of Snow Chrysanthemum ...

Embodiment 3

[0063] Example 3: Sunscreen Efficacy Evaluation of Snow Chrysanthemum Total Flavonoids Extract

[0064] In vitro methods and human experiment methods can be used to evaluate the sunscreen efficacy of cosmetics. The in vitro methods include UV spectrophotometer method and UV transmittance analyzer method. For plant extracts, the sunscreen efficacy can be evaluated by UV spectrophotometry. therefore. The total flavonoids extract of the snow chrysanthemum obtained in the present invention is prepared into a solution with a concentration of 0.008% with distilled water, and is scanned every 10 nm with a UV spectrophotometer in the range of 280-400 nm, and the chromatogram results are shown in image 3 . It can be seen from the figure that the total flavonoids extract of snow chrysanthemum has a maximum absorption wavelength at a wavelength of 372nm, and the absorbance value is 1.903; the average absorbance of UVA and UVB bands is 1.775 and 1.793, so the total flavonoids extract o...

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Abstract

The invention discloses a senecio cineraria extract as well as a preparation method and application of the extract in cosmetics thereof. Senecio cineraria total flavonoids are obtained from senecio cineraria by adopting ethanol heating leaching method. The preparation method comprises the following steps: taking flower head of senecio cineraria, drying, grinding, mixing with ethanol water of a certain concentration, heating to a certain temperature, and continuously leaching for a certain time to obtain an extracting solution; taking the extracting solution, and recovering the solvent under areduced pressure so as to obtain senecio cineraria total flavonoid crude extract; and taking the senecio cineraria total flavonoid crude extract, purifying through a macroporous resin, recovering thesolvent under the reduced pressure, and drying, obtaining the product. The extraction process is simple in flow, the production cost is low, the dissolution rate of the active ingredient can be increased by virtue of high-temperature heating, and the extraction time is shortened; and moreover, experiments prove that the senecio cineraria total flavonoid extract has strong ultraviolet absorption onUVB and UVA bands, has an excellent effect of inhibiting tyrosinase, and can serve as a plant additive to be used for development of sunscreen and whitening cosmetics, and the application range of the senecio cineraria is widened.

Description

technical field [0001] The invention relates to the extract of total flavonoids of snow chrysanthemum, its preparation method and application, especially the application in sunscreen and whitening cosmetics. Background technique [0002] Snow chrysanthemum, whose scientific name is Coreopsis tinctoria Nutt., is an annual herb of the genus Coreopsis in the Asteraceae family. It originated in the Midwest of the United States. The only wild natural chrysanthemum that grows on the snow line in the world is called "Xinjiang Three Treasures" together with snow lotus and Hetian jade. Snow chrysanthemum, as a plant with the same source of medicine and food, has a wide range of pharmacological effects. Studies have found that it has medicinal values ​​such as lowering blood pressure, lowering blood lipids, anti-aging, and anti-tumor. Snow chrysanthemum contains flavonoids, amino acids, volatile oils, sugars and other chemical components, from which more than 300 natural ingredients ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q17/04A61Q19/02
CPCA61Q17/04A61Q19/02A61K8/9789A61K2800/782
Inventor 钟晓明陈敏汤丹
Owner 广州华玺生物科技有限公司
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