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Liquid crystal nano gel capsules for treating colon cancer and preparation method thereof

A technology for gel capsules and colon cancer, which is applied in capsule delivery, medical preparations containing active ingredients, and medical preparations containing active ingredients. It can solve the problem of low cumulative drug release and low drug loading of injection preparations. , the need to use syringes and other issues to achieve the effect of enhancing the anti-cancer effect, avoiding damage to the digestive organs, and preventing damage

Active Publication Date: 2018-09-28
EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the patent No. 201610294386.0 is an invention patent "a liposome composed of palmitoyl ascorbate and hydroxycamptothecin". The cumulative release of drugs in the plastids is not high, that is, the amount of drugs that have a real inhibitory effect on colon cancer cells is not high
Another example is the invention of patent No. 201510595966.9 "An injection preparation containing camptothecin derivatives, its injection, preparation and application", and the invention of patent No. 201110151869.2 "Gel buffer containing camptothecin or its derivatives release injection and its preparation method”, both of them adopt the injection method, need to use a syringe, use on occasion, take inconvenience, and the drug loading capacity of the injection preparation of the drug is not high

Method used

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  • Liquid crystal nano gel capsules for treating colon cancer and preparation method thereof
  • Liquid crystal nano gel capsules for treating colon cancer and preparation method thereof
  • Liquid crystal nano gel capsules for treating colon cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A liquid crystal nanogel capsule for the treatment of colon cancer provided in this embodiment comprises the following components by weight: 4% anticancer active ingredient, 11% poloxamer, 50% natural phospholipid, fatty acid glyceride 27.5%, co-solvent 7.5%;

[0026] The camptothecin, doxorubicin and docetaxel respectively account for 75%, 12.5% ​​and 12.5% ​​of the anticancer active ingredients by weight.

[0027] A kind of preparation method of liquid crystal nanogel capsule for the treatment of colon cancer provided by the present embodiment comprises the following steps:

[0028] S1. Weigh poloxamer, natural phospholipids, fatty acid glycerides, co-solvent, stir at 40°C until completely dissolved, stirring at 400rpm, stirring for 14min to obtain an oily mixed solution;

[0029] S2. Weighing the anti-cancer active ingredient, adding it to the mixed solution obtained in step S1, and dispersing it by ultrasonic waves at a temperature of 70° C. for 10 minutes, with an...

Embodiment 2

[0032] This example is basically the same as Example 1, except that a liquid crystal nanogel capsule for the treatment of colon cancer provided in this example includes the following components in proportion by weight: anticancer active ingredient 6%, Poloxamer 14%, natural phospholipid 40%, fatty acid glyceride 30%, co-solvent 10%.

Embodiment 3

[0034] This example is basically the same as Example 1, except that the liquid crystal nanogel capsule for the treatment of colon cancer provided in this example includes the following components in proportion by weight: anticancer active ingredient 2%, Poloxamer 8%, natural phospholipid 60%, fatty acid glyceride 25%, co-solvent 5%.

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Abstract

The invention discloses liquid crystal nano gel capsules for treating colon cancer. The liquid crystal nano gel capsules comprise, by weight, 2-6% of anticancer active substances, 8-14% of poloxamer,40-60% of natural phospholipid, 25-30% of fatty glyceride and 5-10% of cosolvent. The anticancer active substances include camptothecin and further comprise at least two of taxol, docetaxel and adriamycin, and the weight of camptothecin accounts for 40-75% of total weight of the anticancer active substances. The invention further provides a preparation method of the liquid crystal nano gel capsules. The preparation method includes: well mixing other raw materials, adding the anticancer active substances, performing ultrasonic dispersion, preparing a liquid crystal gel precursor nano preparation into lyophilized powder, and filling capsule shells with the lyophilized powder to obtain the capsules. Encapsulation rate and drug loading capacity of liquid crystal gel are increased to greatest extent, and the liquid crystal nano gel capsules are high in drug release degree and good in targeting performance and anticancer effect.

Description

technical field [0001] The invention belongs to the field of liquid crystal nanogel capsule preparation, in particular to a liquid crystal nanogel capsule for treating colon cancer and a preparation method thereof. Background technique [0002] Due to people's work and rest time, irregular diet, and the influence of the living environment in modern society, human gastrointestinal organ cells have lesions and even cancers from time to time. Colon cancer is a common malignant tumor of the digestive tract that occurs in the colon. It occurs mostly at the junction of the rectum and the sigmoid colon. At present, the treatment of colon cancer is mainly based on surgery, supplemented by chemotherapy and drug therapy. [0003] Camptothecin, paclitaxel, docetaxel, and doxorubicin are common drugs used in the treatment of colon cancer. Camptothecin is a plant anticancer drug, which has good curative effect on gastrointestinal tract and head and neck cancer; paclitaxel is the best n...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K9/06A61K47/10A61K47/24A61K47/14A61K31/4745A61K31/337A61K31/704A61P35/00
CPCA61K9/06A61K9/4858A61K9/4866A61K31/337A61K31/4745A61K31/704A61P35/00A61K2300/00
Inventor 罗亮黄丽萍孟凡玲
Owner EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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