Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions

A technology of aldoside expression and aldoside expression, which is applied in the direction of medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve the problems that the effects of mood and cognitive performance are not very clear, and achieve increased Sympathetic Nervous System Activity, Increases Energy Expenditure, Supports Weight Management Effects

Inactive Publication Date: 2018-08-03
SOC DES PROD NESTLE SA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Carbohydrate-rich foods are known to provide important metabolic fuel for physical performance, but their effects on mood and cognitive performance are not well understood

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions
  • Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions
  • Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0113] The following non-limiting examples present the scientific data that developed and supported the concept of 3'-O-glucuronide epicatechin as a TRPA1 agonist.

[0114] Several epicatechin metabolites were tested in vitro to determine whether any of these compounds were agonists of the cation channel of TRPA1. Specifically, according to Riera et al. (Riera, C.E., Vogel, H., Simon, S.A., Damak, S. and le Coutre, J., Sensory attributes of complex tasting divalent salts aremediated by TRPM5 and TRPV1 channels. (complex tasting The sensory properties of divalent salts are mediated by TRPM5 and TRPV1 channels), J. Neurosci. 29, 2654-2662 (2009)), the calcium imaging method described activation of h-TRPA1 expressing CHO cells was tested.

[0115] Such as Figure 4 The results shown show that 3'-O-glucuronide epicatechin is a TRPA1 agonist. In contrast, the epicatechin metabolite 3'-O-methylepicatechin (chemical structure as Figure 5 shown) is not a TRPA1 agonist, as Figure...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Compositions can comprise the flavanol metabolite 3'-O-glucuronide epicatechin (3GEC). In some embodiments, the amount of 3GEC is effective to increase energy expenditure, sympathetic nervous system activity, and / or fat oxidation. Such a composition can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treatingobesity or overweight. In some embodiments, the composition can improve insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood and / or memory. In some embodiments, the composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, improvement of blood circulation, e.g. in brain, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof. In some embodiments, the composition can treat orprevent dysphagia, e.g., by provoking the swallowing reflex.

Description

Background technique [0001] The present invention generally relates to compositions comprising flavanol metabolites. More specifically, the present invention relates to compositions comprising the flavanol metabolite 3'-O-glucuronide epicatechin, and further relates to methods comprising administering such compositions and methods of preparing such compositions. [0002] Over the past few decades, the prevalence of obesity has risen to epidemic proportions worldwide. Approximately 1 billion people worldwide are overweight or obese, and these conditions increase mortality, mobility costs, and economic costs. Obesity occurs when energy intake exceeds energy expenditure, and the excess energy is stored primarily as fat in adipose tissue. Weight loss and prevention of weight gain can be achieved by reducing energy intake or bioavailability, increasing energy expenditure, and / or reducing storage as fat. [0003] Another condition that afflicts some individuals is dysphagia, whic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7012A61P3/10A61P9/10A61P25/28A61P43/00
CPCA61K31/7048A61P1/00A61P3/04A61P3/10A61P5/50A61P9/00A61P9/08A61P9/10A61P9/12A61P15/00A61P25/00A61P25/02A61P25/28A61P37/04A61P43/00A61K9/0019A61K9/0053
Inventor L·阿克蒂戈雷塔A·帕汀S·米奇里格冈萨雷斯S·卡马乔C·勒格朗J·勒库特E·卡斯塔涅达古铁雷斯I·席尔瓦佐雷兹
Owner SOC DES PROD NESTLE SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap