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Nanofibers with core-shell structure prepared by gel-like oil-in-water emulsion electrospinning and method

An oil-in-water emulsion, electrospinning technology, applied in electrospinning, fiber processing, fiber chemical characteristics, etc., can solve the problems of inappropriate hydrophobic drug loading, lack of cell biological functionality, and unsatisfactory repair effect. , to achieve good biocompatibility and safety, low cost, mild conditions

Active Publication Date: 2020-07-17
杭州犇鑫科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drug carrier materials selected by the above-mentioned patent method are all synthetic polymer materials, which have the formation of outer collagen fibrosis capsule due to excessive hydrophobicity and adhesion of a large number of non-specific proteins, and lack of cell adhesion sites and Biofunctionality leads to unsatisfactory repair effect after long-term implantation in the body, and biocompatibility problems such as the degradation products of some polymers affect the local microenvironment in the body. In addition, the water-in-oil emulsion system is not suitable for hydrophobic drugs. load

Method used

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  • Nanofibers with core-shell structure prepared by gel-like oil-in-water emulsion electrospinning and method
  • Nanofibers with core-shell structure prepared by gel-like oil-in-water emulsion electrospinning and method
  • Nanofibers with core-shell structure prepared by gel-like oil-in-water emulsion electrospinning and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Dissolve 2.5g of gelatin in 10mL of 40% acetic acid solution, magnetically stir until completely dissolved, add 2mL of corn oil into the gelatin acetic acid solution under magnetic stirring, then shear at 6000rpm for 2min at high speed, and then use 250W Ultrasound at the highest power for 3 minutes to obtain a uniformly mixed gel-like oil-in-water emulsion.

[0046] The electrospinning device was used for spinning, and the specification of the electrospinning syringe was 2.5mL, and the needle was flat, 20G. The voltage is 15kV, the flow rate is 0.5mL / h, and the distance is 10cm. It is received by a drum. After completion, a gel-like oil-in-water emulsion electrospun nanofiber with a core-shell structure is obtained.

[0047] Such as figure 1 As shown, the bead-like structures are randomly distributed on the nanofibers, and the diameter of the fibers is about 180-250 nm. The fibers have a core-shell structure, such as figure 2 shown.

Embodiment 2

[0049] Dissolve 2.5g of gelatin in 10mL of 40% acetic acid solution, magnetically stir until completely dissolved, add 4mL of corn oil into the gelatin acetic acid solution under magnetic stirring, then shear at a high speed of 6000rpm for 2min, and then use 250W Ultrasound at the highest power for 3 minutes to obtain a uniformly mixed gel-like oil-in-water emulsion.

[0050] The electrospinning device was used for spinning, and the specification of the electrospinning syringe was 2.5mL, and the needle was flat, 20G. The voltage is 15kV, the flow rate is 0.5mL / h, and the distance is 10cm. It is received by a drum. After completion, a gel-like oil-in-water emulsion electrospun nanofiber with a core-shell structure is obtained.

[0051] Such as image 3 As shown, with the increase of the oil phase ratio, the fiber diameter increases to 210-330nm, and the oil loading capacity of the fiber increases.

Embodiment 3

[0053] Dissolve 2.5g of gelatin in 10mL of 40% acetic acid solution, magnetically stir until completely dissolved, add 6mL of corn oil into the gelatin acetic acid solution under magnetic stirring, then shear at a high speed of 6000rpm for 2min, and then use 250W Ultrasound for 3 minutes at the highest power, and then add 5 mL of 25% aqueous gum arabic solution to adjust the pH to 3.5, and mix well to obtain a gel-like oil-in-water emulsion. The electrospinning device was used for spinning, and the specification of the electrospinning syringe was 2.5mL, and the needle was flat, 20G. The voltage is 15kV, the flow rate is 0.5mL / h, and the distance is 10cm. It is received by a drum. After completion, a gel-like oil-in-water emulsion electrospun nanofiber is obtained.

[0054] Such as Figure 4 As shown, the fibers tend to be uniform, with a diameter of about 410-770nm.

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Abstract

The invention discloses a method for preparing core-shell structured nanofibers from gel-like oil-in-water type emulsion by electrospinning. The method comprises the following steps: (1) dissolving hydrophilic colloids in a solvent to obtain an aqueous phase solution; (2) adding an oil phase solution containing a hydrophobic active substance to the aqueous phase solution, and uniformly mixing thesolutions to obtain the gel-like oil-in-water type emulsion; (3) performing electrospinning on the gel-like oil-in-water type emulsion to obtain the core-shell structured nanofibers. The invention further discloses the core-shell structured nanofibers prepared with the method. The core-shell structured nanofibers have better biocompatibility and biodegradability due to adoption of the hydrophiliccolloids as a shell, and are applicable to entrapment of the hydrophobic active substance due to adoption of the oleophilic oil phase as a core.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a nanofiber with a core-shell structure prepared by electrostatic spinning of a gel-like oil-in-water emulsion and a method thereof. Background technique [0002] Electrospinning technology is that the polymer solution or melt overcomes the surface tension under the action of high-voltage static electricity, forms a Taylor (Taylor) cone at the spinneret, and ejects the polymer jet at high speed, and solidifies after mechanical stretching and solvent volatilization. A construction technique for nanofibrous structures. Electrospun fiber materials have the advantages of large specific surface area, good fiber continuity, small fiber membrane pore size, and high porosity. It can also be used as a drug carrier to improve drug stability and control drug release behavior, showing superior characteristics and great development potential. [0003] Among them, emulsion electros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/02D01F8/18D01D5/00
CPCD01D5/003D01F8/02D01F8/18
Inventor 张辉张岑
Owner 杭州犇鑫科技有限公司
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