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Artificial red blood cell motor and preparation method thereof

An erythrocyte and erythrocyte-like technology, which is applied in the field of medical biomaterials, can solve the problems of poor biological practicability of bubble-driven motors, unfavorable and efficient targeted transportation, and poor targeting recognition ability, and achieves strong repeatability, simple and stable preparation process. good effect

Inactive Publication Date: 2018-05-18
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of hydrogen peroxide in the human body and certain toxic and side effects on the human body, the biological practicability of the bubble-driven motor is poor
In addition, although most micro-nano motors have a certain movement ability, their target recognition ability is poor, which is not conducive to the efficient targeted transport of specific parts.

Method used

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  • Artificial red blood cell motor and preparation method thereof
  • Artificial red blood cell motor and preparation method thereof
  • Artificial red blood cell motor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment provides an artificial red blood cell motor with a diameter of 2 μm-100 μm and a thickness of 500 nm-5 μm, which includes a red blood cell-like skeleton formed by natural hemoglobin, magnetic nanoparticles inside the skeleton and a cell membrane with surface modification, wherein the The magnetic micro-nano particles are iron ferric oxide particles with a particle size of 5nm-500nm, the natural hemoglobin includes one of porcine hemoglobin, horse hemoglobin or bovine hemoglobin, and the cell membrane includes red blood cell membrane, white blood cell membrane or A type of platelet membrane.

[0031] Among them, hemoglobin has the ability to carry and release oxygen. It is not only the main component of red blood cells, but also widely used in artificial oxygen transport carriers. Red blood cells have the ability of long-term blood circulation, white blood cells have the ability of immune clearance, and platelets have the ability to recognize thrombus and ...

Embodiment 2

[0033] See figure 1 with figure 2 ,

[0034] figure 1 It is a schematic diagram of the preparation steps 3 and 4 of the artificial red blood cell motor in this embodiment;

[0035] figure 2 It is the schematic diagram of the artificial red blood cell motor swimming in this embodiment.

[0036] In this example, using hemoglobin, natural cell membranes, and magnetic micro-nano particles as materials, the chemical co-precipitation method and cell membrane fusion technology are used to integrate the main components of red blood cells, hemoglobin, magnetic micro-nano particles, and cell membranes with cell biological properties. Artificial erythrocyte motor with erythrocyte biconcave disc structure. Specifically include the following steps:

[0037] Step 1, preparing the magnetic micro-nano particles:

[0038]a. Dissolve 0.002-0.02mol ferrous chloride and 0.004-0.04mol ferric chloride in 1:2 weight ratio into 100-1000mL deionized water, heat to 70°C under nitrogen protecti...

Embodiment 3

[0048] The difference between this implementation and Example 2 is that the targeting method of the artificial red blood cell motor is specific targeting guided by an external magnetic field.

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Abstract

With a biconcave disk-shaped red blood cell structure with hemoglobin, a natural cytomembrane and magnetic micro-nano particles as materials, by utilizing the chemical coprecipitation method and the cytomembrane fusion technique to integrate the main constituents of the red blood cell, i.e., the hemoglobin, the magnetic micro-nano particles and the cytomembrane with cellular biological properties,the invention prepares an artificial red blood cell motor with a biconcave disk-shaped red blood cell structure. Compared with the prior art, the invention has the following advantages: the repeatability of the invention is high, the preparation process is simple, and the prepared artificial motor has cell-like biological properties and good stability, and can quickly move along an acoustic pressure gradient under the drive of an exogenous ultrasonic field; moreover, the artificial red blood cell motor can also specifically identify cells (such as cancer cells) by means of the surface-modifying natural cytomembrane, or by applying an exogenous magnetic field, the targeting movement of the artificial red blood cell motor along a movement direction is realized, and the artificial red bloodcell motor has a broad application prospect in the biomedical field, such as oxygen target delivery, specific drug carrying, toxin removal and tumor treatment.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an artificial red blood cell motor and a preparation method thereof. Background technique [0002] As early as in the 1966 Hollywood sci-fi movie "Strange Travel", people imagined reducing macroscopic objects to tiny scales and injecting these reduced objects into the human body to perform complex tasks such as health checks, disease treatment, and organ repair. . For half a century, with the continuous development of micro-nano science, these assumptions have gradually become a reality. Micro-nano motor refers to a micro-nano system that can convert chemical energy, sound energy, light energy and other energy into mechanical motion and complete complex tasks. In recent years, micro-nano motors have become a research hotspot in micro-nano science and related fields. Among them, the 2016 Nobel Prize in Chemistry was awarded to three scientists who have made outstan...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/46
CPCA61K9/5115A61K9/5176A61K41/00A61K41/0047
Inventor 贺强高长永林之华周昶
Owner HARBIN INST OF TECH
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