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Composite material capable of adsorbing nucleic acid and preparation method thereof, and device capable of adsorbing nucleic acid

A composite material and nucleic acid technology, applied in the field of nucleic acid adsorption devices, can solve problems such as inability to fit tightly, lack of elasticity, and leakage

Active Publication Date: 2018-05-15
SHENZHEN BIOCOMMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high hardness of the glass frit and its lack of elasticity, it is not only difficult to cut into the desired shape, but also cannot be tightly fitted to the inner wall when assembled in the plastic pipe fittings, resulting in gaps and liquid leakage.
In order to avoid liquid leakage, the welding process is often increased, the operation is complicated and the cost is high

Method used

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  • Composite material capable of adsorbing nucleic acid and preparation method thereof, and device capable of adsorbing nucleic acid
  • Composite material capable of adsorbing nucleic acid and preparation method thereof, and device capable of adsorbing nucleic acid
  • Composite material capable of adsorbing nucleic acid and preparation method thereof, and device capable of adsorbing nucleic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Thermoplastic polymer resin: UHMWPE, molecular weight 2 million, particle size 80-100 mesh.

[0056] Specific particles or fibrous materials that adsorb nucleic acids: silica gel powder, particle size 60-120 mesh, pore size

[0057] Experimental steps:

[0058] 1) Add 70% of UHMWPE and 30% of silica gel powder in sequence in a container, and mix well to obtain spare raw materials;

[0059] 2) Using an aluminum mold with several holes, the diameter of the hole is 4.0mm, and the height is 4.0mm. The spare raw materials are evenly added to the holes, and the compression is shaken;

[0060] 3) After sintering at 200°C for 20 minutes, cool down and take it out.

[0061] The composite material (such as figure 1 Shown) diameter 4.0mm, height 4.0mm, aperture 20-40μm.

Embodiment 2

[0063] Thermoplastic polymer resin: UHMWPE, molecular weight 4 million, particle size 60-80 mesh; HDPE, density 0.945, particle size 60-80 mesh.

[0064] Specific particles or fibrous materials that adsorb nucleic acids: silica gel powder, particle size 150-200 mesh, pore size

[0065] Experimental steps:

[0066] 1) Add 60% of UHMWPE, 20% of HDPE and 20% of silica gel powder in sequence in the mixing container, and mix well to obtain spare raw materials;

[0067] 2) Use an aluminum mold with a length of 297mm, a width of 210mm, and a height of 4.0mm. The spare raw materials are evenly added to the mold, and compressed and vibrated;

[0068] 3) After sintering at 160°C for 60 minutes, cool down and take it out.

[0069] The composite material (such as figure 2 As shown), the length is 297mm, the width is 210mm, the height is 4.0mm, and the aperture is 50-80μm.

Embodiment 3

[0071] Thermoplastic polymer resin: HDPE, density 0.960, particle size 250-300 mesh.

[0072] Specific particulate or fibrous material for adsorbing nucleic acid: glass powder, particle size 300-500 mesh.

[0073] Experimental steps:

[0074] 1) Add HDPE 10% and glass powder 90% in sequence in the mixing container, and mix well to obtain spare raw materials;

[0075] 2) Adopt an aluminum mold with several holes, the diameter of the hole is 7.4mm, and the height is 2.0mm, and the spare raw materials are evenly added to the holes, and compressed and vibrated;

[0076] 3) After sintering at 180°C for 30 minutes, cool down and take it out.

[0077] The composite material (such as image 3 As shown), the diameter is 7.4mm, the height is 2.0mm, and the aperture is 2-5μm.

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Abstract

The invention discloses a composite material capable of adsorbing nucleic acid and a preparation method thereof, and a device capable of adsorbing the nucleic acid. The composite material capable of adsorbing the nucleic acid comprises thermoplastic polymer resin, and specific particles or a fibrous material capable of adsorbing the nucleic acid, wherein the specific particles or the fibrous material capable of adsorbing the nucleic acid is glass powder, and / or glass fiber, and / or quartz powder, and / or silica gel powder. With a technical scheme of the invention, the composite material capableof adsorbing the nucleic acid has good flexibility, facilitates cutting and application, can realize bonding with the inner wall of a pipe, and prevents the leakage of a liquid; meanwhile, the porosity is improved; the compatibility of a sample is enhanced; and the variety and complexity of an applicable sample are increased.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a nucleic acid-absorbing composite material, a preparation method thereof, and a nucleic acid-absorbing device. Background technique [0002] Nucleic acid is an important object in modern biology and medical research. Whether it is to study the structure and function of nucleic acid, or to conduct research on genetic engineering, protein engineering, etc., it is first necessary to separate and purify nucleic acid. [0003] With the rapid development of molecular biology and polymer materials, a variety of materials for adsorbing nucleic acids have emerged. These materials are all solid-phase matrices, and are mainly divided into particles and sheets in terms of shape. Particulate materials mainly include glass powder, magnetic beads and anion exchange resin. Sheet materials mainly adopt silica gel film, glass fiber film and sintered glass frit (patent CN201380055076). [0004] Amo...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30C12Q1/6806B29C64/112B33Y10/00
CPCB01J20/103B01J20/261B01J20/30B01J2220/46B01J2220/4806B01J2220/4812B33Y10/00C12Q1/6806C12Q2523/308
Inventor 陈高明胡玉梅秦智锋刘祺霞
Owner SHENZHEN BIOCOMMA TECH
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