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Method for making small-bore intravascular stent through supercritical gas

A technology for gas preparation and vascular stents, which can be used in prosthesis, medical science, etc., and can solve problems such as complex processes

Inactive Publication Date: 2018-05-11
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to prepare open-pore structures, researchers often combine supercritical gas foaming with other methods, such as particle leaching or chemical foaming, but the process is more complicated.

Method used

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  • Method for making small-bore intravascular stent through supercritical gas
  • Method for making small-bore intravascular stent through supercritical gas
  • Method for making small-bore intravascular stent through supercritical gas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] ●Restricted stage:

[0030] Put the tubular material to be processed into a stainless steel tube mold with an inner diameter of 8 mm, and fill and compact the cavity between the tubular material and the mold and the cavity in the middle of the tubular material with NaCl particles with a diameter of 20±5 μm until dense;

[0031] ●Intermittent foaming stage:

[0032] Put the tubular material with limited filling in the previous step into the autoclave, and perform intermittent foaming with supercritical carbon dioxide. The pressure of the foaming system is set to 2000psi, the temperature is adjusted to 34°C, and maintained for 1 hour. After the end, rapid pressure relief and cooling are performed.

[0033] ●Post-processing stage:

[0034] The NaCl is dissolved with water, the tubular material is taken out from the mold, and the vascular stent of the present invention is obtained after drying.

Embodiment 2-4

[0036] The operation of each step is the same as in Example 1, only the temperature in the intermittent foaming stage is different, and the temperatures in Examples 2-4 are 36, 38, and 40° C. respectively.

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Abstract

The invention provides a method for making a small-bore intravascular stent through supercritical gas. The method comprises a filling limiting stage, an intermittent foaming stage and a post-processing stage, wherein the filling limiting stage comprises the following operations: placing a to-be-processed tubular material into an outer mould which has a limiting effect, and filling and compacting aspace between the tubular material and the outer mould by solid particles I; filling and compacting a cavity in the middle of the tubular material by solid particles II, or adding an inner mould which has a limiting effect in the cavity, and filling and compacting a space between the tubular material and the inner mould by the solid particles II; the intermittent foaming stage includes a polymergas saturating stage and a rapid depressurizing cooling stage, wherein supercritical carbon dioxide is taken as a foaming agent; and the post-processing stage comprises an operation of separating thefoamed tubular material from the mould, so that the intravascular stent is obtained. Different from other means, the stent provided by the invention is designed with many uniform pores in the surface;and in addition, problems of post-processing can be also solved.

Description

technical field [0001] The invention relates to a method for preparing a small-caliber vascular stent with supercritical gas. Background technique [0002] In recent years, cardiovascular disease is one of the diseases with the highest morbidity and mortality at home and abroad. Vascular grafting is an important means of treating many cardiovascular diseases. Clinically, autologous transplantation needs to damage other blood vessels and has limited sources, while allograft transplantation has strong immune rejection and is easy to carry pollution sources. At present, most of the artificial blood vessels used clinically are polytetrafluoroethylene (PTFE) tubes or polyester fiber tubes, which are non-degradable and have no biological activity, and can only maintain blood delivery, especially in small-caliber blood vessels (inner diameter ≤ 6mm). Thrombosis and neointimal thickening are easily formed during the application of the drug, resulting in vascular obstruction. So f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/56A61L27/26B29C44/02
CPCA61L27/26A61L27/50A61L27/507A61L27/56B29C44/02C08L67/04
Inventor 李倩赵娜吕子锐武泽明
Owner ZHENGZHOU UNIV
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