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Meloxicam tablet for pet as well as preparation method and application thereof

A technology for meloxicam and pets, which is applied in the field of meloxicam tablets for pets and their preparation, can solve problems such as unfavorable large-scale popularization and production, complicated preparation methods, etc., and achieves high dissolution rate, improved dissolution rate, and fast dissolution rate. Effect

Inactive Publication Date: 2018-05-01
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its preparation method is complicated, which is not conducive to large-scale production

Method used

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  • Meloxicam tablet for pet as well as preparation method and application thereof

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Effect test

preparation example Construction

[0050] The present invention also provides the preparation method of above-mentioned meloxicam tablet for pet, it comprises the following steps:

[0051] 1. Put meloxicam in an ultrafine pulverization equipment for micronization to obtain micronized meloxicam with a particle size not greater than 75um, wherein the preferred particle size is 30um-75um, and the optimum is 75um. The particle size can be selected in the ultrafine pulverization equipment, and can also be selected by sieving after micronization.

[0052] 2. Then mix micronized meloxicam with disintegrating agent, diluent, and alkalizing agent according to the method of equal increase to obtain a mixture; that is, take a small amount of components and an equal amount of large components, and simultaneously Put it in a mixing machine and mix evenly, then add the same amount of large components as the mixture and mix evenly, and increase the amount in this way until all the large components are added. After determinin...

Embodiment 1

[0061] The meloxicam tablet for pets described in the embodiment of the present invention consists of the following components in parts by weight: 0.86% meloxicam, 8.6% sodium citrate, 37.8% lactose, 40% microcrystalline cellulose, carboxymethyl Starch sodium 8%, silicon dioxide 0.2%, sodium lauryl sulfate 1%, beef powder 3.54%, and 5% povidone aqueous solution, the volume of 5% povidone aqueous solution is the quality of meloxicam 23.2 times; meloxicam is micronized meloxicam prepared by ultrafine pulverization, and the particle size of micronized meloxicam is 75 μm.

[0062] The above-mentioned meloxicam tablets for pets are prepared by the following steps: placing meloxicam in an ultra-fine pulverization device for micronization to obtain micronized meloxicam with a particle size of 75um; then micronized meloxicam Oxycam, sodium carboxymethyl starch, lactose, microcrystalline cellulose and sodium citrate are mixed according to the method of equal increase to obtain a mixtur...

Embodiment 2

[0065] The meloxicam tablet for pets described in the embodiment of the present invention consists of the following components in parts by weight: 0.5% meloxicam, 15% sodium citrate, 39% lactose, 41% microcrystalline cellulose, carboxymethyl Starch sodium 2%, silicon dioxide 1.5%, sodium lauryl sulfate 1%, and 5% povidone aqueous solution, the volume of 5% povidone aqueous solution is 20 times of the quality of meloxicam; Merox Xicam is micronized meloxicam prepared by superfine pulverization, and the particle size of the micronized meloxicam is 45 μm.

[0066] The above-mentioned meloxicam tablet for pets is prepared by the following steps: placing meloxicam in an ultrafine pulverizing device for micronization to obtain micronized meloxicam with a particle diameter of 45um; then micronized meloxicam Oxycam, sodium carboxymethyl starch, lactose, microcrystalline cellulose and sodium citrate are mixed according to the method of equal increase to obtain a mixture, that is, a sma...

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Abstract

The invention discloses a meloxicam tablet for a pet as well as a preparation method and application thereof. The meloxicam tablet for the pet is prepared from the following components: meloxicam, a basifier, a diluent, a disintegrating agent, a fluidizer, a lubricating agent and a proper amount of an adhesive, wherein the weight ratio of the meloxicam is 0.5 to 1.25 percent, and the weight ratioof the basifier is 5 to 15 percent; the meloxicam is micronized meloxicam prepared by superfine grinding; the particle size of the micronized meloxicam is not more than 75 [mu]m. The preparation method of the meloxicam tablet comprises the following steps: performing superfine grinding on the meloxicam, then uniformly mixing the disintegrating agent, the diluent and the basifier according to an equivalent increasing method to obtain a mixture, adding the adhesive into the mixture, then performing granulation to obtain wet particles, drying the wet particles, adding the fluidizer and the lubricating agent, and tabletting the mixture, thus obtaining the meloxicam tablet. The meloxicam tablet is used for preventing and treating animal joint diseases. The meloxicam tablet for the pet is high in dissolution degree, and is favorable for playing the therapeutic effect.

Description

technical field [0001] The invention relates to the technical field of pet medicines, in particular to meloxicam tablets for pets and a preparation method and application thereof. Background technique [0002] Meloxicam is a new type of lenolamide non-steroidal anti-inflammatory drug that can preferentially and selectively inhibit COX-2. It was first launched in Germany and has been approved for marketing in France, Sweden and Switzerland. Many units in my country Manufactured for clinical use in humans. Meloxicam has strong anti-inflammatory, analgesic, and antipyretic effects, and clinical studies have shown that it has less adverse reactions to the gastrointestinal tract and kidneys. Many countries such as Germany, the United States, and the United Kingdom have used it in veterinary clinics and achieved good results. At present, the application in pets in China is still in the experimental research stage. Meloxicam is a white or light yellow crystal or crystalline powder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5415A61K47/12A61K47/02A61K47/38A61K47/36A61P19/02A61P29/00
CPCA61K9/2059A61K9/2009A61K9/2013A61K9/2054A61K31/5415
Inventor 孙迎周淑贞聂姣林孝崇赵奉君
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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