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Automatic continuous production device for nanocapsules and method for preparing nanocapsules

A technology of nanocapsules and production equipment, which is applied in the direction of microcapsule preparations, chemical instruments and methods, and microsphere preparation, and can solve problems such as difficulty in realizing large-scale production and manufacturing of nanocapsules, complicated operation of preparation devices, and high energy consumption, and achieve High shearing and emulsifying efficiency, compact equipment structure, and good particle dispersion

Pending Publication Date: 2018-04-27
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size of the capsules prepared by the above method is mostly above 1 μm (such as the capsules disclosed in the patent application CN106457194A), which is difficult to reach below 100nm. In addition, when preparing capsules below 100nm, not only high pressure is required, but also The energy consumption in the emulsification process is high, and the preparation equipment is usually complicated to operate, making it difficult to realize the large-scale production and manufacture of nanocapsules

Method used

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  • Automatic continuous production device for nanocapsules and method for preparing nanocapsules
  • Automatic continuous production device for nanocapsules and method for preparing nanocapsules
  • Automatic continuous production device for nanocapsules and method for preparing nanocapsules

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Experimental program
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Effect test

Embodiment 1

[0114] The preparation of embodiment 1 nanocapsule 1

[0115] Such as figure 2 As shown, the nanocapsule automatic continuous production equipment in this embodiment includes a storage tank 1, a high-speed shear disperser 20, a high-shear three-stage emulsifier 311, a solvent recovery machine 41, and a centrifuge 42 connected in series through pipelines. And the filling machine 50, wherein the storage tank 1 includes a continuous phase storage tank 11 and a dispersed phase storage tank 12. The outlets of the continuous phase storage tank 11 and the dispersed phase storage tank 12 are respectively provided with valves 110, 120 to control the feeding sequence and feed amount of the continuous phase material and the dispersed phase material. The high-speed shear disperser 20, high Valves 200 , 300 , 410 , and 420 are respectively provided at the outlets of the three-stage shearing emulsifier 311 , the solvent recovery machine 41 and the centrifuge 42 to control the flow of mate...

Embodiment 2

[0119] The preparation of embodiment 2 nanocapsule 2

[0120] Such as image 3 As shown, the nanocapsule automatic continuous production equipment in the present embodiment includes a storage tank 1, a high-speed shear disperser 20, a high-shear three-stage emulsifier 311, a fast membrane emulsifier 312, and a solvent recovery tank 1 connected in series through pipelines. Machine 41, centrifuge 42 and filling machine 50, wherein storage tank 1 includes continuous phase storage tank 11 and dispersed phase storage tank 12. The outlets of the continuous phase storage tank 11 and the dispersed phase storage tank 12 are respectively provided with valves 110, 120 to control the feeding sequence and feed amount of the continuous phase material and the dispersed phase material. The high-speed shear disperser 20, high Valves 200, 301, 302, 410, 420 are respectively set at the outlets of the three-stage shearing emulsifier 311, fast membrane emulsifier 312, solvent recovery machine 41 ...

Embodiment 3

[0124] The preparation of embodiment 3 nanocapsule 3

[0125] Such as Figure 4As shown, the nanocapsule automatic continuous production equipment in the present embodiment includes a storage tank 1, a high-speed shear disperser 20, a high-shear three-stage emulsifier 311, a high-pressure homogenizer 321, and a solvent recovery tank 1 connected in series through pipelines. Machine 41, centrifuge 42 and filling machine 50, wherein storage tank 1 includes continuous phase storage tank 11 and dispersed phase storage tank 12. The outlets of the continuous phase storage tank 11 and the dispersed phase storage tank 12 are respectively provided with valves 110, 120 to control the feeding sequence and feed amount of the continuous phase material and the dispersed phase material. The high-speed shear disperser 20, high Valves 200, 301, 303, 410, 420 are respectively set at the outlets of the three-stage shearing emulsifier 311, high-pressure homogenizer 321, solvent recovery machine 4...

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Abstract

The invention relates to the field of nano material preparation, and in particular, relates to an automatic continuous production device for nanocapsules and a method for preparing the nanocapsules byusing the device. The device includes a storage tank, a shearing device, an emulsifying homogenizing device and a solvent recovery device which are connected in series in sequence through a pipeline,wherein the storage tank includes a dispersed phase storage tank for storing a dispersed phase material and a continuous phase storage tank for storing a continuous phase material; the emulsifying homogenizing device preferably includes a multistage emulsifier, a membrane emulsifier or a high pressure homogenizer or a combination thereof. The method for preparing the nanocapsules by using the device includes the steps: preparing the dispersed phase material and the continuous phase material respectively, mixing, carrying out high-speed shearing, emulsifying and homogenizing to obtain a fine emulsion, and then recovering to obtain the nanocapsules by a solvent. The device can prepare the nanocapsules with uniform and controllable particle size, the process is simple, the energy consumptionof the preparation process is low, and the large-scale automatic continuous production of the nanocapsules can be realized.

Description

technical field [0001] The invention belongs to the field of nano material preparation. Specifically, the present invention relates to an automatic continuous production equipment for nanocapsules and a method for preparing nanocapsules. Background technique [0002] Microcapsule technology refers to the process of using solid particles, liquid, gas or empty shells as the core material of capsules, and forming a continuous and extremely thin capsule on the outside with polymer film-forming materials. As an effective commercial technology, microencapsulation technology has been widely used in many fields such as medicine, food, pesticide, veterinary drug, and vaccine. However, in the traditional preparation technology, the capsules prepared by emulsification methods such as mechanical stirring and ultrasound have a large particle size (mostly micron), poor particle dispersibility, and uneven particle size, especially when used as a drug controlled release carrier. The drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04B01F13/10
CPCB01J13/04B01F33/80B01F33/834B01F33/836
Inventor 崔海信王琰其他发明人请求不公开姓名
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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