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Preparation method and application of polymer hollow microcapsule

A polymer and hollow micro technology, applied in botany equipment and methods, microcapsules, applications, etc., to achieve the effect of simple reaction conditions, easy mass production, and adjustable particle size

Active Publication Date: 2018-04-03
湖州闪思新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem solved by the present invention is to provide a convenient and low-cost method for preparing polymer hollow microcapsules. The preparation steps of the method are simple, the operation is convenient, and the particle size and shell permeability of the microcapsules are adjustable. There are disadvantages of methods such as osmotic swelling method, template and layer-by-layer electrostatic self-organization

Method used

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  • Preparation method and application of polymer hollow microcapsule
  • Preparation method and application of polymer hollow microcapsule
  • Preparation method and application of polymer hollow microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The specific embodiment that prepares oil-in-water Pickering emulsion with hydrophilic nanocellulose as emulsifying agent is as follows:

[0045] 1) dispersing hydrophilic nanocellulose in an aqueous solution containing sodium chloride as the aqueous phase A of the Pickering emulsion;

[0046] 2) using oily solvent toluene as the oil phase B of the Pickering emulsion;

[0047] 3) Mix the above-mentioned water phase A and oil phase B according to the ratio of 7:3, and use an ultrasonic cell pulverizer to sonicate for 2 minutes to obtain an oil-in-water Pickering emulsion.

[0048] The test parameters and test results are summarized as follows:

[0049]

[0050]

[0051] According to experiments 1 to 8, the diameter of the Pickering emulsion droplet is closely related to the concentration of sodium chloride in the aqueous phase. The surface of nanocellulose prepared by sulfuric acid hydrolysis has a strong negative charge, and a certain amount of salt needs to be ...

Embodiment 2

[0054] Using the oil-in-water Pickering emulsion of hydrophilic nanocellulose emulsification as a template, the specific examples of preparing polymer hollow microcapsules (hollow microcapsule, HM) are as follows:

[0055] 1) dispersing hydrophilic nanocellulose in an aqueous solution containing sodium chloride as the aqueous phase A of the Pickering emulsion;

[0056] 2) Using oily solvent, oil-soluble initiator azobisisobutyronitrile (AIBN), different polymer monomers and crosslinking agent divinylbenzene as the oil phase B of the Pickering emulsion;

[0057] 3) The above-mentioned water phase A and oil phase B were mixed according to the ratio of 7:3, and the nitrogen gas was continuously introduced for 30 minutes, and then the Pickering emulsion was obtained after ultrasonic cell pulverizer was used for 2 minutes under the protection of nitrogen gas. Kling emulsion was reacted at 70 degrees Celsius for 12 hours;

[0058] 4) Finally, the above reaction solution was washed ...

Embodiment 3

[0068] The concrete embodiment that prepares water-in-oil Pickering emulsion with hydrophobic nanocellulose as emulsifying agent is as follows:

[0069]1) Firstly, hydrophobic modification is carried out to the hydrophilic nanocellulose to prepare hydrophobic nanocellulose. Hydrophobic nanocellulose can be obtained by introducing hydrophobic groups on nanocellulose through small molecule reaction or polymer grafting. In this example, butyryl chloride or cinnamic acid chloride was used to hydrophobically modify nanocellulose. Disperse 1 gram of nanocellulose into 100 milliliters of dimethylformamide, add 1 milliliter of triethylamine, 1 gram of 4-dimethylaminopyridine and 1 gram of butyryl chloride or cinnamoyl chloride, and react at room temperature for 24 hours to obtain Hydrophobically modified nanocellulose;

[0070] 2) dispersing the above-mentioned hydrophobic nanocellulose in an oily solvent as the oil phase A of the Pickering emulsion;

[0071] 3) Use water as the aq...

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Abstract

The invention designs a preparation method and application of a polymer hollow microcapsule. The method comprises the following steps of using nano cellulose as an emulsifier of a Pickering emulsion,adding an initiator, a monomer and a cross-linking agent into a discontinuous phase of the emulsion, afterwards, using the Pickering emulsion as a template, and preparing the polymer hollow microcapsule through the polymerization and cross linking reactions, in a liquid drop of the emulsion, of the monomer. The nano cellulose used in the method has advantages of being good in biocompatibility, wide in source, low in cost, green and environmental friendly, and the like; the range of a polymer to which the method is applicable is wide; hydrophobic and hydrophilic polymer monomers can be selectedand used; an environmental stimuli-responsive polymer or a polymer with a special function, such as a pH (potential of Hydrogen)-response, temperature-response or conducting polymer and the like, canbe selected and used; moreover, the method is simple, convenient and quick; reaction conditions are simple; the polymer hollow microcapsule is adjustable in particle size, low in cost and easy in quantity production and the obtained polymer hollow microcapsule can be used for the entrapment and the controlled release of a medicine and can be widely applied to the fields of medicines, agricultureand the like.

Description

technical field [0001] The invention relates to the field of material preparation and application, in particular to a preparation method and application of polymer hollow microcapsules. Background technique [0002] Due to the advantages of low density, large specific surface area, and high loading capacity, polymer hollow microcapsules have broad application prospects in the fields of drug entrapment and controlled release, white pigments, catalyst carriers, and microreactors. One of the research hotspots. Therefore, it is of great scientific significance and application value to explore new methods for preparing polymer hollow microcapsules. At present, the commonly used methods for preparing polymer hollow microcapsules include osmotic swelling method, template, and layer-by-layer electrostatic self-organization methods. However, these methods often have the disadvantages of many steps and cumbersome processing. [0003] The osmotic swelling method is a method of prepar...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F212/36C08F220/54C08F222/38C08F220/20C08F2/32A61K9/50A61K47/32A61K47/38A01N25/28A01N25/10
CPCA01N25/10A01N25/28A61K9/5026A61K9/5042C08F2/32C08F212/08C08F220/20C08F220/54C08F212/36C08F222/385
Inventor 张振张博雅
Owner 湖州闪思新材料科技有限公司
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