Arginine aspirin tablet and preparation method thereof

A technology of arginine aspirin and arginine, which is applied in the field of arginine aspirin tablets and its preparation, can solve problems such as insufficient and complete reaction, influence on product stability, and lower production efficiency, so as to prolong the storage period and facilitate large-scale production. The effect of mass production and simple manufacturing process

Inactive Publication Date: 2018-03-06
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method weighs aspirin and arginine raw materials according to the molar ratio of 1:1, and finally the two cannot fully react, and the pH value of the solution after the full reaction is alkaline, and it needs to be adjusted with hydrochloric acid, the reaction time is long, and the cost is high , reducing production efficiency
In addition, the reaction solution is directly freeze-dried to form crystals, which contain impurities and affect the stability of the product.

Method used

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  • Arginine aspirin tablet and preparation method thereof
  • Arginine aspirin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An arginine aspirin tablet is made from the following raw materials in the weight ratio: 85 parts of arginine, 85 parts of aspirin, 5 parts of starch slurry, 0.6 part of powdered sugar, 0.6 part of sago dextrin, 4 parts of pregelatinized starch 4 parts of calcium sulfate dihydrate, 3 parts of microcrystalline cellulose, 0.5 parts of tannic acid, 0.5 parts of magnesium stearate, 0.4 parts of sodium alginate, and 80 parts of absolute ethanol.

[0026] A preparation method for arginine aspirin tablet, comprising the steps of:

[0027] (1) Add the pregelatinized starch and magnesium stearate in the formula amount into deionized water, heat in a water bath at 75°C, and stir slowly while heating to obtain mixture A;

[0028] (2) Add the starch slurry, powdered sugar, and dextrin in the formula amount into deionized water, ultrasonically treat for 5 minutes, and heat in a water bath at 75°C to obtain mixture B;

[0029] (3) Take calcium sulfate dihydrate, microcrystalline cel...

Embodiment 2

[0034] An arginine aspirin tablet is made from the raw materials in the following weight ratio: 65 parts of arginine, 65 parts of aspirin, 3 parts of starch slurry, 0.3 part of powdered sugar, 0.3 part of sago dextrin, 2 parts of pregelatinized starch 2 parts of calcium sulfate dihydrate, 2 parts of microcrystalline cellulose, 0.3 parts of tannic acid, 0.3 parts of magnesium stearate, 0.3 parts of sodium alginate, and 60 parts of absolute ethanol.

[0035] A preparation method for arginine aspirin tablet, comprising the steps of:

[0036] (1) Add the pregelatinized starch and magnesium stearate in the formula amount into deionized water, heat in a water bath at 65°C, and stir slowly while heating to obtain mixture A;

[0037] (2) Add the starch slurry, powdered sugar and dextrin in the formula amount into deionized water, ultrasonically treat for 5 minutes, and heat in a water bath at 65°C to obtain mixture B;

[0038] (3) Take calcium sulfate dihydrate, microcrystalline cell...

Embodiment 3

[0043]An arginine aspirin tablet is made from the following raw materials in weight ratio: 65 parts of arginine, 65 parts of aspirin, 3 parts of starch slurry, 0.6 part of powdered sugar, 0.6 part of sago dextrin, 3 parts of pregelatinized starch 3 parts of calcium sulfate dihydrate, 3 parts of microcrystalline cellulose, 0.3 parts of tannic acid, 0.5 parts of magnesium stearate, 0.3 parts of sodium alginate, and 80 parts of absolute ethanol.

[0044] A preparation method for arginine aspirin tablet, comprising the steps of:

[0045] (1) Add the pregelatinized starch and magnesium stearate in the formula amount into deionized water, heat in a water bath at 65°C, and stir slowly while heating to obtain mixture A;

[0046] (2) Add the starch slurry, powdered sugar, and dextrin in the formula amount into deionized water, ultrasonically treat for 5 minutes, and heat in a water bath at 75°C to obtain mixture B;

[0047] (3) Take calcium sulfate dihydrate, microcrystalline cellulos...

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Abstract

The invention provides an arginine aspirin tablet and a preparation method thereof, relating to the field of medical technology, including arginine, aspirin, starch slurry, powdered sugar, dextrin, pregelatinized starch, calcium sulfate dihydrate, and microcrystalline cellulose , Tannic Acid, Magnesium Stearate, Sodium Alginate, Absolute Ethanol. The present invention uses arginine aspirin as the active ingredient and adds a variety of adjuvant components. Compared with other related dosage forms of aspirin, the present invention has better solubility, faster drug effect and more complete absorption, and arginine inhibits platelets of aspirin The aggregation effect has a synergistic effect, and at the same time it can resist the side effects of aspirin gastric mucosal damage and protect the gastric mucosa; it greatly increases the stability of arginine aspirin tablets, prolongs the storage period of arginine aspirin tablets, and is convenient for mass production. Mass production, and the manufacturing process is simple and the cost is low.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an arginine aspirin tablet and a preparation method thereof. Background technique [0002] Since Aspirin was developed by Bayer Company of Germany in 1897, it has been used for a hundred years. It is the most common non-steroidal antipyretic, analgesic and anti-inflammatory drug in clinical practice. Aspirin drugs have been widely used in the world due to their wide range of applications, especially the prevention and treatment of some diseases that seriously endanger human health such as cardiovascular diseases, and they are cheap and easy to use. and research. [0003] Aspirin, as an antipyretic and analgesic, is widely produced and used in my country. The biggest disadvantage is that it has a strong stimulating effect on the gastric mucosa after oral administration. Aspirin can cause side effects such as stomach discomfort, nausea, and vomiting. Long-term use of aspirin inh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K31/616A61K31/198A61P29/00
CPCA61K31/616A61K9/2054A61K9/2059A61K31/198A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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