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Medicinal preparation for asthma and trachitis and preparation method of medicinal preparation

A technology for pharmaceutical preparations and bronchitis, which is applied in the field of pharmaceutical preparations for asthma and bronchitis and its preparation. It can solve the problems of high cost, unclear pharmacological effects, and many types of raw materials, and achieve short time, shorten extraction time, and improve extraction. rate effect

Inactive Publication Date: 2018-02-09
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant's patented technology "2013103914698, a kind of Xiangma Hanchuan patch and its preparation process" and "2015101716371, an application of Xiangma Hanchuan patch and its detection method" are improvements to the existing technology, mainly by adding multiple A kind of raw material medicine, its effect is better than known medicine, but there are many kinds of raw materials, pharmacological action is not clear and the defect such as high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A pharmaceutical preparation for asthma and bronchitis, which is prepared according to the following steps:

[0024] Take 200g of ephedra, 200g of mustard seed, 33g of clove, 100g of asarum, 333g of short ground tea, and 200g of ginger;

[0025] Grind cloves and asarum into coarse powder, slice ginger, add 6 times the weight of water, and use a high-speed shearer to cut for 15 minutes to obtain soaking liquid. Distilled for 2 hours, the volatile oil was placed separately, and the medicinal liquid and medicinal residue were set aside;

[0026] Mix ephedra, mustard seeds and low ground tea, crush them into 200-mesh powder, then add them to the reaction kettle, add 5 times the weight of water, stir evenly, heat to 70°C, and control the pressure to 1Mpa, keep the heat and pressure for 30min, Then drop to normal pressure and normal temperature, filter and collect filtrate A, and filter residue for subsequent use;

[0027] Combine the filter residue and the medicinal residu...

Embodiment 2

[0035] Acute toxicity test: 5 times the amount of the pharmaceutical preparation prepared in Example 1 was pasted on the intact and damaged skin of rabbits each time, and there was no irritation after repeated administration, no allergic reaction to the skin, and no toxic and side effects .

[0036] Long-term toxicity test: 10 times of the amount of the pharmaceutical preparation prepared in Example 1 is pasted on the rabbit back (double lung projection back) of depilation, each time pasting 4 hours, pasting 1 time every day, continuous 2 weeks. Observation of its blood picture, lung, liver and kidney function showed no toxic effects; no toxic damage was found in the heart, liver, spleen, lung, kidney and other organs by pathological section. Therefore, it is suggested that the clinically recommended dosage is safe to use.

Embodiment 3

[0038] Animal experiment

[0039] As experimental animals, 40 male wistar rats of SPF grade were selected from the experimental animal center of our company. They were 6 weeks old and weighed (170±15) g. They were normal group, asthma model group, Example 1 group, and Comparative Example 1 group, with 10 rats in each group.

[0040]Establishment of chronic asthma rat model Except for the normal group, rats in other groups were prepared by referring to the Palmans method to prepare rat models of chronic asthmatic airway inflammation sensitized by ovalbumin (OVA). The sensitization phase was from the first OVA injection on day 1 to day 14, and the continuous challenge phase (6 weeks) was from day 15 to day 56. Sensitization stage: On the first day, the rats were intraperitoneally injected with 1 mL of OVA and aluminum hydroxide mixed solution (containing OVA10mg and aluminum hydroxide 100mg); on the eighth day, the rats were intraperitoneally injected again to strengthen the se...

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PUM

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Abstract

The invention belongs to the technical field of medicines and discloses a medicinal preparation for asthma and trachitis. The medicinal preparation comprises the following raw materials: 200g of ephedra sinica, 200g of mustard seeds, 33g of clove, 100g of asarum, 333g of Japanese ardisia herb and 200g of ginger. The medicinal preparation disclosed by the invention is unique in process, and animaltests show that the medicinal preparation is relatively good in inflammation inhibition effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine preparation for asthma and bronchitis and a preparation method thereof. Background technique [0002] Asthma and bronchitis in children are common and frequently-occurring diseases in pediatric clinics, which not only endanger children's health, but also cause huge economic burdens to families and society. According to data reports, the prevalence rate of childhood asthma in my country is 0.5% to 2%, and it is as high as 5% in some places. There are about 20 to 40 million children in the country. Modern medicine believes that bronchial asthma is a respiratory hyperresponsive disease caused by hypersensitivity. In terms of drug treatment, it is emphasized that according to the needs of the condition, in addition to the use of antispasmodic and antiasthmatic drugs (symptomatic treatment), anti-airway allergic inflammation drugs should also be used in combi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/70A61P11/06A61P11/00
CPCA61K9/7023A61K36/17A61K36/185A61K36/268A61K36/31A61K36/61A61K36/9068A61K47/44A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 林凡友姚其胜林荣郭增光杜玲杰
Owner XIANGYU PHARMA
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