Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ornidazole purity standard substance and preparation method and application thereof

A standard substance, ornidazole technology, applied in the field of standard value transfer in stoichiometry, can solve problems such as human health hazards, and achieve the effect of ensuring traceability

Inactive Publication Date: 2018-01-26
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
View PDF9 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Prohibited and restricted drugs are seriously abused in the process of animal husbandry. Because of their strong toxic side effects and toxic effects, and the residues in animal tissues will be transmitted to humans through the food chain, long-term trace intake can cause various diseases. human health hazard

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ornidazole purity standard substance and preparation method and application thereof
  • Ornidazole purity standard substance and preparation method and application thereof
  • Ornidazole purity standard substance and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1, the definite value of ornidazole purity standard substance

[0060] The definite value step of ornidazole purity standard substance of the present invention is as follows:

[0061] 1. Uniformity test

[0062] According to the requirements of JJG 1006-1994 "Technical Specifications for Primary Reference Materials", the homogeneity test was carried out for the standard materials. The present invention adopts the variance analysis method to statistically check the uniformity of the ornidazole purity standard substance, randomly extracts 15 packages from the subpackaged ornidazole, each package is taken in parallel three times, and the weight-volume method is used to prepare 100mg / L methanol solution, Using the conditions when the value was fixed, liquid chromatography-area normalization method inspection, the obtained uniformity data and statistical results are shown in Table 1.

[0063] Table 1 ornidazole purity standard substance homogeneity inspection re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ornidazole purity standard substance, a preparation method and an application thereof. The preparation method comprises the following steps: 1) sampling ornidazole raw material powder, employing a high performance liquid chromatography area normalization method to measure the content to obtain a purity fixed value of the ornidazole raw material powder; 2) measuring masspercentage of water, non-volatile impurity and organic volatile impurity in the ornidazole raw material powder, calculating according to a formula I to obtain the purity fixed value 1 of the ornidazole purity standard substance, and labeling as PHPLC-AN; wherein PHPLC-AN=P0*[100%-Xw-Xn-Xv] in the formula I; 3) taking the ornidazole raw material powder and employing a quantitative nuclear magneticmethod to measure the content to obtain the purity fixed value 2 of the ornidazole purity standard substance, and labeling as PNMR; and 4) calculating the average value of PHPLC-AN and PNMR to obtainthe purity fixed value of the ornidazole purity standard substance. The ornidazole purity standard substance can be used for detecting drug residue in livestock and poultry products, and provides technical support and substance guarantee for establishing a national agricultural product quality and safety risk assessment as well as monitoring traceablility system.

Description

technical field [0001] The invention relates to ornidazole purity standard substance and its preparation method and application, and belongs to the technical field of standard quantity transfer in chemical measurement. Background technique [0002] Prohibited and restricted drugs are seriously abused in the process of animal husbandry. Because of their strong toxic side effects and toxic effects, and the residues in animal tissues will be transmitted to humans through the food chain, long-term trace intake can cause various diseases. Hazard to human health. Prohibited and restricted drugs have become an important parameter in the risk assessment and monitoring activities of the agricultural product quality and safety of the Ministry of Agriculture. In order to ensure the consistency, comparability, traceability and accuracy and reliability of the measurement results, corresponding reference materials are urgently needed. [0003] Ornidazole Chinese alias Onidazole, English ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/96G01N27/62G01N24/08G01N21/73
Inventor 周剑王敏杨梦瑞王彤彤张丽媛
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com