Preparation process of silicification-free rubber plug

Abstract

The invention discloses a preparation process of a silicification-free rubber plug. The preparation method comprises the steps of compounding rubber, flaking rubber, molding, volcanizing and molding,cutting, washing and drying, and packaging, and further comprises the steps of sequentially coating a dimethylsiloxane prepolymer solution and a polyvinylidene fluoride resin dispersion on the surfaceof washed and dried rubber plug, and drying and curing coating layers, wherein the dimethylsiloxane prepolymer solution is mainly prepared from the following components in parts by weight: 1-5.5 parts of dimethylsiloxane prepolymer, 0.2-0.5 part of silane crosslinking agent, 100 parts of organic solvent A, and the polyvinylidene fluoride resin dispersion is mainly prepared from polyvinylidene fluoride resin emulsion containing 5-15% of solid and silicon rubber catalyst. The cured rubber plug has a compound coating layer, low surface friction coefficient, good anti-ultraviolet performance, chemical resistance and anti-aging performance, and the silicification process in preparation of the rubber plug is prevented.

Description

technical field [0001] The invention relates to the technical field of production of medicinal rubber stoppers, in particular to a preparation process of a silicone-free rubber stopper. Background technique [0002] Due to the high surface friction coefficient of butyl rubber plugs, it is necessary to add emulsified silicone oil and silicone oil for siliconization during the manufacturing process. The degree of silicification of rubber stoppers is also a key factor affecting the probability of filling and stoppering in pharmaceutical factories. The frictional resistance between non-siliconized and siliconized butyl rubber stoppers and dispensing tracks is 50-100 times different. However, the technical defect brought about by silicification is that after the drug filling is completed, it needs to be sterilized by high pressure with a stopper. During the above process, the silicone oil residue will be released from the butyl rubber stopper and dissolved into the drug; It can...

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Problems solved by technology

However, the above-mentioned solution does not completely solve the friction between the rubber stopper and the sub-packaging track and the problems of the neck of the rubber stopper and the bottleneck of the bottle mouth

The improved technical solution of siliconization-free also includes covering the surface of the rubber stopper or covering the neck with a film, but the film-coated rubber stopper is mainly used for pharmaceutical packaging with high pH, ​​and it is prone to weak adhesion of the film material, and the film is easy to fall off. The film material has poor elasticity, and the film-coated rubber plug has high hardness, which is prone to problems such as poor self-sealing and poor acupuncture performance, and is also more expensive.

The improved technical scheme also includes a grafted rubber stopper spray liquid disclosed in CN105907298A, which mainly consists of hydroxyl-terminated dimethylsiloxane, hydrogen-containing silicone oil, catalyst, coupling agent and organic solvent, and the hydroxyl-terminated The surface friction coefficient of silica gel obtained by forming a film from terminal dimethyl siloxane is large, which also cannot solve the problem of friction between the dispensing track and bottle mouth jamming

In addition, because the viscosity of blocked dimethyl siloxane increases suddenly after mixing with the catalyst, it is not conducive to the uniform coating on the surface of the rubber stopper

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