Lisinopril compound preparation and preparation method thereof

A technology of compound preparations and excipients, applied in the field of biomedicine, can solve problems such as poor antihypertensive effect, and achieve the effects of being suitable for popularization, controlling blood sugar, and stabilizing blood pressure

Inactive Publication Date: 2017-09-22
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: when the existing lisinopril tablets are used for diabetic patients with hypertension, it is difficult to lower blood pressure and blood sugar at the same time, and the blood pressure lowering effect is not good.

Method used

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  • Lisinopril compound preparation and preparation method thereof
  • Lisinopril compound preparation and preparation method thereof

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preparation example Construction

[0028] The present invention also provides a preparation method of the above lisinopril compound preparation, comprising the following steps:

[0029] a. Dissolve lisinopril in an aqueous povidone solution with a concentration of 5-10%, add starch, gelatin and an appropriate amount of water, stir evenly to make a soft material A, and place it at room temperature for 20-24 hours;

[0030] b. Stir and mix gliquidone, dextrin, microcrystalline cellulose and micropowder silica gel evenly, then add polyethylene glycol, stir evenly to make soft material B for later use;

[0031] c. Take the soft material A prepared in step a and the soft material B prepared in step b at the same dose, press them evenly to form tablets, soak them in a lactose solution with a concentration of 80-90% for 3-5 hours, and dry them to obtain Lisinopril compound preparation.

[0032] Wherein, in the preparation method of the above lisinopril compound preparation, the water content in the soft material A de...

Embodiment 1

[0040] Embodiment 1 prepares lisinopril compound preparation with the method of the present invention

[0041] The formula of the lisinopril compound preparation consists of: 10 parts of lisinopril, 10 parts of gliquidone, 100 parts of lactose, 30 parts of starch, 70 parts of dextrin, 100 parts of microcrystalline cellulose, poly 20 parts of vitamin C, 30 parts of gelatin, 20 parts of micronized silica gel, and 50 parts of polyethylene glycol.

[0042] Concrete preparation method operation is as follows:

[0043] a. Dissolve lisinopril in a 5% povidone aqueous solution, add starch, gelatin and an appropriate amount of water, stir evenly to make a soft material A, and place it at room temperature for 20 hours;

[0044] b. Stir and mix gliquidone, dextrin, microcrystalline cellulose and micropowder silica gel evenly, then add polyethylene glycol, stir evenly to make soft material B for later use;

[0045]c. Take the soft material A prepared in step a and the soft material B pr...

Embodiment 2

[0046] Embodiment 2 prepares lisinopril compound preparation with the method of the present invention

[0047] The formula of the lisinopril compound preparation consists of: 20 parts of lisinopril, 20 parts of gliquidone, 10 parts of lactose, 10 parts of starch, 20 parts of dextrin, 10 parts of microcrystalline cellulose, poly 10 parts of vitamin C, 20 parts of gelatin, 10 parts of micronized silica gel, 30 parts of polyethylene glycol.

[0048] Concrete preparation method operation is as follows:

[0049] a. Dissolve lisinopril in 10% povidone aqueous solution, add starch, gelatin and appropriate amount of water, stir evenly to make soft material A, and place it at room temperature for 24 hours;

[0050] b. Stir and mix gliquidone, dextrin, microcrystalline cellulose and micropowder silica gel evenly, then add polyethylene glycol, stir evenly to make soft material B for later use;

[0051] c. Take the soft material A prepared in step a and the soft material B prepared in s...

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Abstract

The present invention belongs to the technical field of biomedicine, and particularly relates to a lisinopril compound preparation and a preparation method thereof. In the prior art, the blood pressure lowering effect is not good in the application of the existing lisinopril tablet in the diabetes patient with hypertension. Based on the problem in the prior art, the invention provides a lisinopril compound preparation, which comprises, 10-20 parts of lisinopril, 10-20 parts of gliquidone, and 100-500 parts of an auxiliary material. The preparation method comprises: preparing a soft material A from lisinopril and materials, preparing a soft material B from gliquidone and an auxiliary material, taking the same doses of the soft material A and the soft material B, uniformly tableting to form a tablet, placing into a lactose solution with a concentration of 80-90%, soaking for 3-5 h, and drying to obtain the lisinopril compound preparation. According to the present invention, the prepared lisinopril compound preparation can lower the blood glucose concentration, and can provide the good blood pressure lowering effect in the case of the normal blood glucose, and the preparation method is simple, and is suitable for promotion use.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a lisinopril compound preparation and a preparation method thereof. Background technique [0002] Lisinopril is a lysine derivative of enalaprilat, which belongs to the third generation of angiotensin-converting enzyme inhibitors, which can inhibit the activity of angiotensin-converting enzymes and reduce the concentration of angiotensin II and aldosterone , Elevate plasma renin activity, lead to peripheral vasodilation and decrease in vascular resistance, thus producing antihypertensive effect. [0003] Lisinopril has an excellent antihypertensive effect and can effectively control blood pressure for 24 hours. The results of dynamic blood tests show that the antihypertensive effect can last for more than 24 hours once a day, and has no adverse effect on the circadian rhythm of heart rate and blood pressure. Lisinopril also has good renal protection, effectively ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K31/64A61K9/20A61P9/12A61P3/10
Inventor 朱正标陶元明张汉华李苗苗范小雪
Owner 江苏黄河药业股份有限公司
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