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Production technology of amoxicillin capsule

A technology for amoxicillin capsules and production process, applied in the field of production technology of amoxicillin capsules, can solve the problems of low dissolution rate and poor stability of amoxicillin, and achieve the advantages of improving curative effect, ensuring stability and reducing toxic and side effects. Effect

Inactive Publication Date: 2017-08-29
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by this invention is that the dissolution rate of amoxicillin in the prior art is relatively low, and the stability is relatively poor. Improvement, increase the dissolution rate of capsules, make oral absorption complete, improve curative effect, and reduce toxic and side effects

Method used

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  • Production technology of amoxicillin capsule

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Effect test

Embodiment 1

[0018] The invention provides a kind of production technology of amoxicillin capsule, and concrete steps are successively:

[0019] (1) Soft material production process: first weigh 1000 parts of amoxicillin raw material fine powder and 8 parts of pregelatinized starch, then add them to the ultrafine pulverizer for pulverization and mixing. The working pressure of the superfine pulverizer is 0.2MPa, and the internal work The temperature is 38°C, the pulverization and mixing time is 18 minutes, and finally a fine powder mixture with a particle size of 900 meshes is obtained; then 20 parts of purified water are added to the fine powder mixture, and purified water is added to the fine powder mixture and then stirred 12min, the temperature of purified water is 33°C; then make amoxicillin granules in a wet granulator, and then dry with a boiling dryer. The air inlet temperature was lowered and controlled to 42°C, and the drying was continued for 55 minutes to finally obtain dry amo...

Embodiment 2

[0024] (1) Soft material production process: first weigh 1000 parts of amoxicillin raw material fine powder and 10 parts of pregelatinized starch, and then add it to a superfine pulverizer for pulverization and mixing. The working pressure of the superfine pulverizer is 0.2MPa, and the internal work The temperature is 38°C, the grinding and mixing time is 18 minutes, and finally a fine powder mixture with a particle size of 900 meshes is obtained; then 25 parts of purified water are added to the fine powder mixture, and the purified water is added to the fine powder mixture and then stirred 12min, the temperature of purified water is 33°C; then make amoxicillin granules in a wet granulator, and then dry with a boiling dryer. The air inlet temperature was lowered and controlled to 42°C, and the drying was continued for 55 minutes to finally obtain dry amoxicillin granules with a water content of 3%;

[0025] (2) Granulation process: crush the dried amoxicillin granules, sieve t...

Embodiment 3

[0029] (1) Soft material production process: first weigh 1000 parts of amoxicillin raw material fine powder and 12 parts of pregelatinized starch, then add it to a superfine pulverizer for pulverization and mixing. The working pressure of the superfine pulverizer is 0.2MPa, and the internal work The temperature is 37°C, the grinding and mixing time is 16 minutes, and finally a fine powder mixture with a particle size of 900 meshes is obtained; then 28 parts of purified water are added to the fine powder mixture, and the purified water is added to the fine powder mixture and then stirred 12min, the temperature of purified water is 32°C; then make amoxicillin granules in a wet granulator, and then dry with a boiling dryer. Reduce the temperature of the drying air intake to 42°C, continue drying for 55 minutes, and finally obtain dry amoxicillin granules with a moisture content of 3%;

[0030] (2) Grain sizing process: the dried amoxicillin granules are crushed, sieved with a 50-...

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Abstract

The invention discloses a production technology of an amoxicillin capsule. The production technology comprises the steps of carrying out a soft material preparation procedure, namely firstly weighing1,000 parts of amoxicillin raw material powder and 8-12 parts of pregelatinized starch, adding the raw materials to an ultrafine grinder for grinding and mixing evenly to prepare a fine powder mixture of which the particle sizes are 900 meshes; adding 20-28 parts of purified water to the fine powder mixture, stirring and mixing evenly, then preparing amoxicillin particles in a wet granulator and drying by using a boiling dryer to obtain dried amoxicillin particles; carrying out a granulation procedure, namely crushing the dried amoxicillin particles, granulating through a 50mesh sieve and adding 18-23 parts of carboxymethyl starch sodium and 3-5 parts of magnesium stearate for mixing evenly; and finally carrying out a filling and polishing procedure and a packaging procedure to obtain a finished product amoxicillin capsule. The prescription and the technological process of the amoxicillin capsule are improved, the dissolution rate of the capsule is improved, oral absorption is complete, the curative effect is improved and the toxic and side effects are reduced.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, in particular to a production process of amoxicillin capsules. Background technique [0002] Amoxicillin Capsules, indications: Amoxicillin is suitable for the following infections caused by sensitive bacteria (non-beta-lactamase-producing strains): 1. Otitis media caused by hemolytic streptococcus, pneumoniae, staphylococcus or Haemophilus influenzae , sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections. 2. Urinary tract infection caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infection caused by hemolytic streptococcus, staphylococcus or Escherichia coli. 4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic Streptococcus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae. 5. Acute simple gonorrhea. 6. This product can still be used to treat t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/43A61K47/36A61P31/04A61J3/07
CPCA61K31/43A61J3/074A61K9/1652A61K9/4883
Inventor 谢德龙崔微晞
Owner SICHUAN PHARMA
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