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Compound biological patch and preparation method thereof

A technology of biological patch and composite structure, applied in the field of composite biological patch and its preparation, can solve the problems of difficult to control degradation time, recurrence, etc., and achieve the effect of improving the efficiency of decellularization process and good anti-infection.

Active Publication Date: 2017-08-18
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of patch is more popular in foreign countries, but it is difficult to control the degradation time, and there is often recurrence, requiring a second operation

Method used

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  • Compound biological patch and preparation method thereof
  • Compound biological patch and preparation method thereof
  • Compound biological patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Primary treatment of raw materials:

[0048] Take the small intestinal submucosa tissue material (small intestinal submucosa) and divide it into specified sizes, remove useless tissues, such as lymphoid tissue, rinse with tap water, and then rinse with purified water until the surface is free of stains, and place the washed small intestinal submucosa tissue material in a filter. Use a water filter such as a net for more than 5 minutes to drain the water. When taking the small intestine, measure the filtered small intestine with a volume measuring device such as a measuring cylinder.

[0049] (2) Virus inactivation:

[0050] Use peracetic acid-ethanol solution to soak small intestinal submucosa tissue material. This process can be carried out in a stainless steel bucket. The concentration of peracetic acid volume percentage concentration is 2%, and the volume percentage concentration of ethanol is 20%. The volume ratio of small intestinal submucosa tissue to materi...

Embodiment 2

[0071] Embodiment 2: the physical and chemical properties of the material prepared in embodiment 1, biological detection

[0072] 1. The physical properties of the prepared composite patch were tested, and the testing items included the measurement of wrapping, suture retention, tensile strength, rupture strength, and porosity.

[0073] 1) Porosity measurement: The porosity of the material is measured with a porosity tester. Results: The porosity of the sample provided in Example 1 was 60%.

[0074]2) Test of suture retention: Method: Use No. 2-0 surgical suture or stainless steel wire of the same diameter to suture at 2 mm from the edge of one end of the repair piece, and fix the suture or stainless steel wire and the other end of the repair piece on the tension meter , stretch at a speed of 20mm / min until the suture point is torn, and record the tension when the suture point is torn. Three batches of samples were tested according to the above method. Results: The suture t...

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Abstract

The invention relates to a compound biological patch and a preparation method thereof. The compound biological patch comprises a macromolecular material layer and a lower matrix material layer of a mucous membrane of small intestines, wherein the macromolecular material layer comprises a macromolecular material with mesh structures, and the lower matrix material layer of the mucous membrane of the small intestines comprises collagenous fibers and growth factors. By fusing the macromolecular material with animal tissues, the compound biological patch has relatively high mechanical properties, and the animal source portion retains a natural ECM three-dimensional structure, so that the compound biological patch is low in immunogenicity and strong in anti-infection ability.

Description

technical field [0001] The invention relates to the technical field of animal-derived and high-molecular material implantable medical devices, which are composed of synthetic high-molecular materials and decellularized small intestinal submucosa matrix, and specifically relate to a composite biological patch and a preparation method thereof. Background technique [0002] The repair materials used in medicine can be divided into four categories: the first category is non-absorbable polyester patch, polypropylene patch, expanded polytetrafluoroethylene patch; the second category is absorbable polyglycolic acid, Polylactic-glycolic acid; the third type is composite patch; the fourth type is acellular extracellular matrix biological patch (ECM) [0003] It has been reported in the literature: non-absorbable material patch, polyester patch, abdominal incisional hernia patients applied material repair complication analysis showed that the recurrence rate was 34%, the infection rat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/24A61L27/18A61L27/16A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/16A61L27/18A61L27/24A61L27/3629A61L27/3687A61L27/3691A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/404A61L2300/412A61L2300/414A61L2300/604A61L2430/40C08L67/04C08L23/12
Inventor 赵博王洪权赵延瑞李学军张晋辉
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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