Compound biological patch and preparation method thereof
A technology of biological patch and composite structure, applied in the field of composite biological patch and its preparation, can solve the problems of difficult to control degradation time, recurrence, etc., and achieve the effect of improving the efficiency of decellularization process and good anti-infection.
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Embodiment 1
[0047] (1) Primary treatment of raw materials:
[0048] Take the small intestinal submucosa tissue material (small intestinal submucosa) and divide it into specified sizes, remove useless tissues, such as lymphoid tissue, rinse with tap water, and then rinse with purified water until the surface is free of stains, and place the washed small intestinal submucosa tissue material in a filter. Use a water filter such as a net for more than 5 minutes to drain the water. When taking the small intestine, measure the filtered small intestine with a volume measuring device such as a measuring cylinder.
[0049] (2) Virus inactivation:
[0050] Use peracetic acid-ethanol solution to soak small intestinal submucosa tissue material. This process can be carried out in a stainless steel bucket. The concentration of peracetic acid volume percentage concentration is 2%, and the volume percentage concentration of ethanol is 20%. The volume ratio of small intestinal submucosa tissue to materi...
Embodiment 2
[0071] Embodiment 2: the physical and chemical properties of the material prepared in embodiment 1, biological detection
[0072] 1. The physical properties of the prepared composite patch were tested, and the testing items included the measurement of wrapping, suture retention, tensile strength, rupture strength, and porosity.
[0073] 1) Porosity measurement: The porosity of the material is measured with a porosity tester. Results: The porosity of the sample provided in Example 1 was 60%.
[0074]2) Test of suture retention: Method: Use No. 2-0 surgical suture or stainless steel wire of the same diameter to suture at 2 mm from the edge of one end of the repair piece, and fix the suture or stainless steel wire and the other end of the repair piece on the tension meter , stretch at a speed of 20mm / min until the suture point is torn, and record the tension when the suture point is torn. Three batches of samples were tested according to the above method. Results: The suture t...
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