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A self-assembled multi-pulse release method for fat-soluble drugs

A fat-soluble drug, multi-pulse technology, applied in pharmaceutical formulations, organic active ingredients, medical preparations with non-active ingredients, etc. Increase fixing performance, wide application range and obvious effect

Active Publication Date: 2020-06-30
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the existence of pores between crystal precipitates and the poor immobilization effect of colloidal media on drugs, water-soluble drugs are easy to leak, and in practice many drugs are water-insoluble or fat-soluble

Method used

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  • A self-assembled multi-pulse release method for fat-soluble drugs
  • A self-assembled multi-pulse release method for fat-soluble drugs
  • A self-assembled multi-pulse release method for fat-soluble drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of a self-assembled multi-pulse release device for fat-soluble drugs loaded with cholesterol nanocapsules (precipitation ring layer is calcium hydrogen phosphate crystals)

[0036] (1) Weigh 0.017g of cholesterol and dissolve it in 10ml of chloroform, then weigh 0.017g of surfactant sodium dodecylbenzene sulfonate and dissolve it in 50ml of twice distilled water. Add the chloroform solution into 50ml of the surfactant-containing solution, and obtain a transparent nanocapsule solution with a concentration of about 0.01mol / L by evaporation to remove the solvent. Such as image 3 As shown, the diameter of the nanocapsules carrying fat-soluble cholesterol is between 60-70nm as measured by DLS, which proves that the fat-soluble cholesterol is encapsulated by the surfactant to form stable nanocapsules.

[0037] (2) After mixing the above-mentioned nanocapsule solution, calcium chloride solution with a concentration of 0.1mol / L and gelatin solution with ...

Embodiment 2

[0040] Example 2 Preparation of a self-assembled multi-pulse release device for fat-soluble drugs loaded with prednisone nanocapsules in sodium cholate (precipitation ring layer is calcium hydrogen phosphate crystals)

[0041] Weigh 0.017g prednisone fat-soluble drug and dissolve it in 10ml chloroform, then weigh 0.17g surfactant sodium cholate and dissolve it in 50ml double distilled water. The chloroform solution of prednisone is added into 50 ml of sodium cholate solution, and the nanocapsule solution with a concentration of about 0.01 mol / L is prepared by evaporation to remove the solvent.

[0042] Remaining steps are identical with embodiment 1.

Embodiment 3

[0043] Example 3 Preparation of a self-assembled multi-pulse release device for fat-soluble drugs loaded with paclitaxel nanocapsules (precipitation ring layer is calcium hydrogen phosphate crystals)

[0044] (1) Weigh 0.017g of paclitaxel fat-soluble drug and dissolve it in 10ml of chloroform, then weigh 0.17g of surfactant sodium dodecyl sulfonate and dissolve it in 50ml of double distilled water. Add the chloroform solution into 50 ml of sodium dodecylsulfonate solution, and prepare a nanocapsule solution with a concentration of about 0.01 mol / L by evaporation to remove the solvent.

[0045] Remaining steps are identical with embodiment 1.

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Abstract

The invention discloses a self-assembled multi-pulse release method for lipid-soluble medicines. The self-assembled multi-pulse release method comprises the following steps: firstly, preparing nano capsules with the lipid-soluble medicines, and uniformly mixing the nano capsules with a gelatigenous medium material; and in the mixed medium of the nano capsules and the medium materials, building Liesegang ring patterns, and generating periodic sediment crystals. The self-assembled multi-pulse release method is wide in application range, the stability of medicines and fixation properties of the medicines in medium systems are improved, and a very good release control function is achieved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a self-assembled multi-pulse release method for fat-soluble drugs. Background technique [0002] The sustained release of drugs has always been one of the key topics studied by scientists. Sustained release of drugs is to delay the release, absorption, distribution, metabolism and excretion of drugs in the body by appropriate methods, so as to prolong the drug effect. A dosage form that keeps the blood drug concentration constant so that it can better exert its curative effect. [0003] Polymer materials are widely used in the field of drug sustained release, and drug sustained release materials refer to a class of polymer materials that can delay drug release for more than 8 hours. It is the current research focus in the field of pharmacy, and it is also one of the important directions of research in chemistry, biology, and materials science. Some macromolecular materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/62A61K31/575A61K31/573A61K31/337
CPCA61K31/337A61K31/573A61K31/575
Inventor 倪恨美时凯吴敏周金慧
Owner SOUTHEAST UNIV
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