A kind of nerve repair material, preparation method and application

Abstract

Disclosed are a nerve repair material, a preparation method and the use thereof. The nerve repair material comprises collagen, a polysaccharide substance, active factors and nerve-regeneration-promoting factors, and has a three-dimensional porous mesh structure, has no immunogenicity, can degrade in vivo, and can be in the form of a sheet or a hollow tube. The nerve repair material is prepared using the small intestine submucosa tissue as the raw material and subjecting same to steps such as the pre-processing of the tissue, virus inactivation, immunogen-removal, growth factor compounding, and freeze-drying. The nerve repair material is used in nerve repair medical instruments, can effectively protect the damaged nerve, can form a microenvironment for protecting the regeneration of the nerve, can promote the regeneration of the damaged nerve, and can also play the role of a barrier, effectively isolating the damaged part of the nerve from the surrounding tissues, and preventing the fibroblasts in the surrounding tissues from invading the damaged part of the nerve.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a nerve repair material, which is used for compounding growth factors in the immunogen-removing matrix of the small intestinal submucosa, protecting damaged and defective peripheral nerves, preventing tissue adhesion and inducing nerve repair. Background technique [0002] Peripheral nerves pervade the skin, mucous membranes, muscles, bones, joints, blood vessels, and internal organs of the whole body. Therefore, human tissues will be affected by peripheral nerves due to stretching, cutting, compression, burns, ischemia, etc., causing nerve damage. Peripheral nerves are the cell protrusions of neurons, also known as nerve fibers, composed of axons, myelin sheaths and Schwann sheaths. The function of the axon is the conduction of nerve impulses between neurons and nerve terminal structures, myelin sheath prevents the diffusion of excitation, and Schwann sheath is comp...

AI Technical Summary

Problems solved by technology

[0003] The traditional method of repairing nerves is limited to sutures, and does not use biomaterials for damage protection. After sutures are sutured, edema will appear at the anastomosis, and excessive proliferation of a large number of fibroblasts will lead to fibrosis at the anastomosis. If the local scar Or tissue adhesion, it will seriously affect the recovery of nerve function

At the same time, most nerve injuries are accompanied by muscle, tendon, and fascia injuries. The repair of these tissues is mainly based on scar repair, which will also lead to excessive scar formation around the nerve anastomosis and affect nerve regeneration.

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