Application of chlorophyll and/or derivatives thereof in preparing medicine for preventing and/or treating iron overload

Abstract

The invention relates to application of chlorophyll and / or derivatives thereof in preparing medicine for preventing and / or treating iron overload. The invention further relates to a combination of the chlorophyll and / or the derivatives thereof and an iron chelating agent for preventing and / or treating iron overload. The chlorophyll and / or the derivatives thereof can improve iron-deficiency anemia, lower in-vivo iron content and avoid excessive iron chelation and has no obvious side effect. Treatment effect of the iron chelating agent can be improved by combining the chlorophyll and / or the derivatives thereof with the iron chelating agent, so that treatment period when the iron chelating agent is used solely can be shortened, risk of generating adverse reaction caused by long-time administration of the iron chelating agent is lowered, and economic burden of patients is relieved substantially.

Description

technical field [0001] The present invention relates to the use of chlorophyll and / or its derivatives, in particular to the use of chlorophyll and / or its derivatives for preventing and / or treating iron overload, and belongs to the field of medicine. Background technique [0002] Iron overload, also known as iron overload, is when the body's iron supply exceeds iron demand. There are many reasons for the formation of iron overload. For example, the body takes in too much iron due to oral iron, injection of iron, blood transfusion, etc.; another example, gene mutation, drinking, virus infection, etc. lead to disturbance of liver regulation of iron balance; another example, Inherited or acquired iron metabolism abnormalities, etc.; in addition, certain diseases can also affect the metabolism of iron in the microenvironment, resulting in the selective deposition of iron in specific cells, such as viral hepatitis, which causes iron to be deposited in liver cells, resulting in iro...

AI Technical Summary

Problems solved by technology

[0006] Although iron chelation therapy has achieved certain curative effect, its disadvantages are as follows: (1) Adverse reactions are obvious and numerous, including ocular and ear toxicity, growth retardation, bone changes, granulocyte and leukopenia, gastrointestinal dysfunction, digestive tract Hemorrhage, liver and kidney failure, etc.; (2) Water-soluble, so that it cannot enter cells to transfer a large amount of iron bound to transferrin; (3) Desferrioxamine has a short half-life (20-30min), requiring long-term subcutaneous or intravenous injection, and poor compliance ; ⑷The treatment cost is expensive, for example, the price of Orbeanco brand deferiprone tablets is 680 yuan / bottle (30 tablets), adults need to take 3 times a day, 3 tablets each time, and the daily drug price is 204 yuan; ⑸ Use The population is limited, the elderly, pregnant women, lactating women and children under 6 years old should not use it or use it with caution

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