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Application of psyllium husk dietary fiber in preparation of intestinal injury protection preparation

A technology of psyllium husk and dietary fiber, which is applied in the field of medicine, can solve the problems of strong toxic side effects and high concentration of action, and achieve the effect of no adverse reactions and wide application prospects

Inactive Publication Date: 2017-06-13
TIANJIN UNIV OF COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some drugs currently used clinically to treat intestinal injury have certain pharmacological activities, they have some unavoidable shortcomings, including high concentration of action, strong toxic and side effects, etc.

Method used

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  • Application of psyllium husk dietary fiber in preparation of intestinal injury protection preparation
  • Application of psyllium husk dietary fiber in preparation of intestinal injury protection preparation
  • Application of psyllium husk dietary fiber in preparation of intestinal injury protection preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Effect of psyllium husk dietary fiber on survival rate and body weight of radiation-induced intestinal injury mice

[0027] Choose 6-8 weeks old C57BL / 6 mice, half male and half male (body weight 25±2g), and randomly divide them into four groups:

[0028] Blank group: 10 mice fed normally without any treatment;

[0029] Negative control group for intestinal injury: after 1 week of normal feeding, 10 mice were irradiated (15Gy) to the abdominal cavity with an X-ray irradiator;

[0030] Experimental group: Add psyllium husk dietary fiber to the feed during normal feeding, and 10 mice were irradiated (15Gy) in the abdominal cavity with an X-ray irradiation machine after 1 week;

[0031] Psyllium husk dietary fiber blank control group: 10 mice that were fed with psyllium husk dietary fiber during normal feeding.

[0032] Among them, the experimental group and the blank control group were fed with dietary fiber dose of psyllium seed husk at 100 mg / kg, once a day...

Embodiment 2

[0034] Example 2. Effects of Psyllium Semen Husk Dietary Fiber on the Intestinal Structure and Function of Radiation-Induced Intestinal Damage Mice

[0035] Intestinal damage in mice after radiation exposure will lead to diarrhea in mice. According to the shape of mouse feces, diarrhea can be divided into four grades: 0 (healthy), 1 (mild), 2 (moderate), 3 (severe) ). Blank group, intestinal injury negative control group and experimental group mice were treated in the same manner as in Example 1, and the mice had diarrhea within one week after radiation treatment. The results are shown in image 3 . The results showed that the incidence and degree of diarrhea in mice pre-fed dietary fiber of psyllium husk were significantly lower than those in the control group after irradiation. It shows that the dietary fiber of psyllium husk can alleviate the intestinal dysfunction induced by radiation.

[0036] In order to further observe the changes in the intestinal structure of the m...

Embodiment 3

[0038] Example 3. Effect of psyllium husk dietary fiber on the translocation of intestinal flora in mice with radiation-induced intestinal injury

[0039]The mice in the blank group, the intestinal injury negative control group and the experimental group were treated in the same manner as in Example 1, and the mice were killed 3.5 days after radiation exposure, and the mesenteric lymph nodes and livers of the mice were taken to analyze the bacterial content. The specific method is as follows: first, use the fluorescent quantitative PCR method to amplify 16SrDNA of a known quantity of Escherichia coli, draw a standard curve of the relationship between the gene cycle threshold and the bacterial content, and then calculate the corresponding bacteria according to the 16SrDNA gene cycle threshold in the sample to be tested. content. see results Figure 7 , the results showed that compared with normal mice, the bacterial content in the mesenteric lymph nodes of the control group mi...

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Abstract

The invention discloses novel application of a psyllium husk dietary fiber in intestinal injury. The taking dosage of the psyllium husk dietary fiber is 100mg / kg, and oral administration is adopted. The psyllium husk dietary fiber provided by the invention has the advantages that the pharmacological action is remarkable, the psyllium husk dietary fiber has the integrity of improving the intestinal injury, the translocation of intestinal floras is reduced, the expression of inflammatory factors in an intestinal tract is reduced, intestinal cell apoptosis is effectively reduced, and the toxic and side effects are small, so that, the psyllium husk dietary fiber can be used for preparing a drug or functional food for preventing the intestinal injury.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new application of psyllium husk dietary fiber in the prevention of intestinal damage, including the application of the psyllium husk dietary fiber in the preparation of drugs or functional foods for preventing intestinal damage. [0002] technical background [0003] The psyllium seed husk dietary fiber is extracted from the husk of the psyllium psyllium seed of the family Plantago, which is rich in fiber content, accounting for about 80%. In addition, the psyllium husk also contains Nutrients such as gum, glucoside, protein, polysaccharide, vitamin B1 and choline. Dietary fiber has the functions of water absorption, viscosity, binding of organic compounds, cation exchange and bacterial fermentation, and has been widely used as a nutritional supplement for maintaining intestinal health and preventing constipation. [0004] It has been reported in the literature that the dietary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/68A61P1/00A23L33/22
Inventor 李炳娟赵辉
Owner TIANJIN UNIV OF COMMERCE
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