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Preparation method of ZnPc-UCNP@SiO2-PEG-G nano composite

A nanocomposite and compound technology, applied in the field of biomedical materials, can solve the problems of insufficient drug targeting and shallow treatment depth, and achieve the effects of high fluorescence resonance energy transfer efficiency, reduced side effects, and obvious targeting

Inactive Publication Date: 2017-05-31
FUZHOU UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a ZnPc-UCNP@SiO 2 -The preparation and application of PEG-G nanocomposites solve the problems of insufficient drug targeting and shallow treatment depth in photodynamic therapy

Method used

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  • Preparation method of ZnPc-UCNP@SiO2-PEG-G nano composite

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Embodiment 1

[0035] A ZnPc-UCNP@SiO 2 -The preparation method of PEG-G nanocomposite, concrete steps are:

[0036] 1) Weigh 0.4 g NaOH in a 100 mL reactor, then measure 20 mL deionized water, 30 mL ethanol, 7.5 mL oleic acid and 4 mL n-hexane, and stir to form a uniform solution; weigh 0.8 mmol rare earth nitrate (0.2390 gY(NO 3 )·6H 2 O, 0.1065 g Yb (NO 3 ) 5H 2 O, 0.0069 g Er(NO 3 ) 5H 2 O) Dissolved in 5 mL deionized water and slowly added dropwise to the above reaction solution at 20 drops / min, then weighed 0.1314 g (3.2 mmol) NaF dissolved in 5 mL deionized water and added to the reaction solution, took out the stirring magnet Package and place in an oven at 180 °C for 6 h; after the reaction, cool naturally to room temperature, extract with 30 mL cyclohexane three times, collect the cyclohexane layer, add excess ethanol to collect by centrifugation; then use deionized water and ethanol alternately Wash 3 times, and finally disperse in 10 mL cyclohexane for use;

[0037] 2) Me...

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Abstract

The invention discloses a preparation method of a ZnPc-UCNP@SiO2-PEG-G nano composite. The preparation method comprises the following steps: synthesizing UCNPs (upconversion nano particles) through a micro-emulsion method, coating the surfaces of the UCNPs with SiO2, carrying out surface amination on the SiO2 to obtain UCNP@SiO2-NH2, modifying the surface of the UCNP@SiO2-NH2 to obtain ZnPc-UCNP@SiO2-PEG-COOH nano composite, loading targeting molecules gefitinib (G) to the surface of the ZnPc-UCNP@SiO2-PEG-COOH nano composites to obtain the ZnPc-UCNP@SiO2-PEG-G nano composite. The nano composite has the advantages that the particle distribution is uniform, the crystallinity is good, the photodynamic activity is good, and the ZnPc-UCNP@SiO2-PEG-G nano composite is hopefully developed into a high-efficiency and low-toxicity novel drug-loading system.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, specifically a ZnPc-UCNP@SiO 2 - Preparation method of PEG-G nanocomposite. Background technique [0002] Photodynamic therapy is also called photochemical therapy (Photodynamic therapy, PDT), which refers to the use of light of a specific wavelength to irradiate a drug (photosensitizer, PS) that has been injected locally or systemically into the body in advance, and the photosensitizer is then activated and reacts with oxygen molecules to produce Cytotoxic reactive oxygen species (ROS) can cause irreversible damage to tumor tissue through direct and indirect effects. Photodynamic therapy is different from traditional tumor treatment methods. It has selectivity to target tissue and damage degree, can reduce damage to normal tissue, can metabolize faster in the human body, and avoids toxicity to other parts of the body. High stability and photostability. However, traditional photod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/22A61P35/00B82Y5/00B82Y20/00A61K31/5377
CPCA61K41/0057A61K31/5377A61K47/22B82Y5/00B82Y20/00A61K2300/00
Inventor 贾潇薛金萍叶焕年年夫宇
Owner FUZHOU UNIV
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