A kind of low-swellable degradable thermosensitive hydrogel and preparation method thereof

Abstract

The invention provides a preparation method for a low-swelling degradable thermo-sensitive hydrogel. The method comprises the following steps: (1) by taking ethylene glycol monomethyl ether as an initiator, initiating the ring opening polymerization of lactide and glycolide and preparing a polyethylene glycol polyethylene propylene glycol diblock copolymer A; (2) initiating the reaction between polyhydroxy-alcohol and excessive cyclic dicarboxylic anhydride, thereby preparing a carboxy-terminal polycarboxylate compound B; (3) dissolving the copolymer A and the compound B into a good solvent and reacting under an effect of a condensing agent, thereby acquiring a poly-end polyethylene glycol polyethylene propylene glycol diblock copolymer C; (4) dissolving the copolymer C into water, thereby acquiring the solution in a certain concentration, wherein the solution is converted into gel G under a certain temperature. According to the invention, the hydrogel is in a solution state under the low temperature and is gradually converted into gel following the temperature rise; the swelling degree of the formed gel is less than 20%; the hydrogel has a solution-gel reversible property; the gel is degradable in body; the degradation product can be absorbed by the organism and has excellent biocompatibility; the gel is capable of containing drugs so as to serve as a slow release material.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and in particular relates to a low-swelling degradable temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] In recent years, smart hydrogels, as a class of biomedical polymer materials, have become one of the current research hotspots. In smart hydrogels, temperature-sensitive polymer materials are another type of temperature-sensitive hydrogels that respond to stimuli due to changes in external temperature, that is, they are in a gel state that cannot flow freely near human body temperature, and at room temperature It is in the state of free flowing solution. The solution-gel transition performance of this kind of temperature-sensitive polymer material caused by temperature changes endows it with excellent injectability, and the injection and implantation of the material does not require surgery and has little trauma to the human body. This ...

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Problems solved by technology

However, it uses a polyhydroxyl initiator to directly synthesize star-shaped polylactide, then carries out carboxylation of the terminal group, and then reacts with the terminal amino-group polyethylene glycol to obtain a star-shaped amphiphilic copolymer, which can form a glue in aqueous solution. bundles, but cannot form a densely cross-linked triple network interpenetrating structure, so it is difficult to form a dense gel structure, and the swelling rate of the formed micelles is relatively high

In addition, the preparation of the star-shaped polymer uses expensive double-terminated amino-based polyethylene glycol, which is expensive and difficult to produce commercially.

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