Attapulgite/polyacrylic acid nano compound gel containing sodium alginate and preparation method thereof

Abstract

The invention discloses attapulgite / polyacrylic acid nano compound gel containing sodium alginate and a preparation method thereof. The attapulgite / polyacrylic acid nano compound gel is characterized by being prepared from, by weight, 1-3 parts of sodium alginate, 5-10 parts of attapulgite, 1-2 parts of calcium carbonate, 15-20 parts of hydrochloric acid solution, 30-40 parts of zinc sulfate solution, a proper amount of absolute ethyl alcohol, 2-5 parts of silane coupling agent KH-570, 1-2 parts of bamboo fiber, 2-5 parts of silane coupling agent KH-550, 2-3 parts of chitosan, 0.4-1 part of cerium nitrate, 5-10 parts of acrylic acid, a proper amount of nitrogen and a proper amount of distilled water. The compound gel can be matched with added chitosan, is rich in amino, can provide amino to be grafted to the attapulgite, participate in crosslinking and enhance the stability of a network structure, and meanwhile the chitosan has very good absorbability and can increase the carrying-attaching amount of a carrier. By being matched with the added sodium alginate and the like, pore channels of the attapulgite are enriched, and the adsorption capacity is also enhanced.

Description

technical field [0001] The invention relates to an attapulgite carrier and its preparation, in particular to an attapulgite / polyacrylic acid nanocomposite gel containing sodium alginate and a preparation method thereof. Background technique [0002] Drug carrier release and targeting system can reduce drug degradation and loss, reduce side effects, and improve bioavailability, so more and more attention has been paid to its research. Due to its unique amphiphilic structure, polymer surfactants can self-assemble to form various forms of aggregates, such as micelles, microemulsions, gels, liquid crystals, vesicles, etc. These aggregates have the ability to entrap drug molecules and at the same time have good permeability to the membrane, which has become an important research field of drug carriers. Attapulgite is a hydrous-rich magnesium-aluminosilicate mineral with attapulgite as the main component and a special fibrous crystal structure. Due to its excellent adsorption, i...

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Problems solved by technology

[0003] In his master's thesis "Gel Phenomenon and Application of Attapulgite / Polymer Nanocomposites Prepared by In-Situ Polymerization", Zhu Longxiang prepared nanocomposite hydrogels using attapulgite and acrylic acid, but they are used as drug carriers. There are also problems of poor loading capacity, antibacterial properties, and slow-release properties