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Andrographolide nanometer inhalant and application thereof to treatment of bacterial pneumonia

A technology of andrographolide, inhalation agent, applied in the field of biomedicine, can solve the problems of insoluble in water, limited application, difficulty in absorption and the like

Inactive Publication Date: 2017-04-26
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Andrographolide is a diterpenoid lactone compound, insoluble in water, difficult to absorb, and low in vivo bioavailability, which greatly limits its application

Method used

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  • Andrographolide nanometer inhalant and application thereof to treatment of bacterial pneumonia
  • Andrographolide nanometer inhalant and application thereof to treatment of bacterial pneumonia
  • Andrographolide nanometer inhalant and application thereof to treatment of bacterial pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1. andrographolide nanoemulsion

[0047] Take 0.5g of andrographolide, 2g of isopropyl myristate, 4g of polyoxyethylene 35 castor oil, and 30ml of water, mix them evenly in a beaker, stir them mechanically at 1000rpm to form colostrum, and homogenize at 15000psi with a high-pressure homogenizer 3 times, andrographolide nanoemulsion was obtained.

Embodiment 2

[0048] Embodiment 2. andrographolide liposomes

[0049] Andrographolide liposomes were prepared by ethanol injection method. Weigh soybean lecithin 1.57g, cholesterol 0.157g, andrographolide 0.28g, vitamin E 0.098g, add 40ml of ethanol, and ultrasonically dissolve them completely; take 100ml of phosphate buffer solution of pH 6.5 prepared according to the Chinese Pharmacopoeia, place in On a magnetic stirrer, use a needle tube to inject the above ethanol solution into the buffer solution at a rate of 1ml per minute. After the injection is completed, transfer the suspension to a round bottom flask, stir it magnetically for 30 minutes, and then evaporate the solvent on a water bath rotary evaporator at 40°C. After 60 minutes, until there is no ethanol smell, the remaining suspension is andrographolide liposome. The appearance of andrographolide liposome is a clear and transparent solution with light blue opalescence. Observing andrographolide liposomes are evenly distributed u...

Embodiment 3

[0051] Take vitamin E 0.1g, cetyl palmitate 2.0g, caprylic acid / capric glyceride 0.4g, heat in a 53°C water bath until melted, and mix with andrographolide 1.0g as the oil phase; soy lecithin for injection 1.5g, 1.8g of polyoxyethylene 660-12 hydroxystearate, add 100ml of water for injection, stir and dissolve, heat to 53°C, and use it as the water phase; under the condition of stirring and nitrogen, add the water phase dropwise to the oil at the same temperature In the phase, continue to stir for a certain period of time to form colostrum, sonicate the probe for 5 minutes, stir at 0-2°C for 2 hours, and filter through 0.22 μm micropores to obtain solid lipid nanoparticles of andrographolide. Observed under a transmission electron microscope, most of them are particles below 100nm.

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Abstract

The invention discloses an andrographolide nanometer inhalant and an application thereof to treatment of bacterial pneumonia. The andrographolide nanometer inhalant is prepared by an andrographolide nanometer administration system, and the system is selected from andrographolide liposome, andrographolide microemulsion, andrographolide nano-emulsion, andrographolide nonionic surfactant vesicles, andrographolide nanoparticles, and andrographolide nanocapsules. The dosage form of the andrographolide nanometer inhalant is selected from aerosol, water spray, and powder spray. The andrographolide nanometer inhalant can increase bioavailability and reduce stimulation, and is easy to penetrate into deep part of lung tissue; the inhalant can target and locate lesion location, and benefits for treatment of bacterial pneumonia; and the inhalant is convenient to carry and use.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an andrographolide nano-inhalation agent and its application in the treatment of bacterial pneumonia. Background technique [0002] Andrographolide is an effective chemical component in the leaves of Andrographis paniculata, and one of the active components of traditional Chinese medicine in my country. Andrographis paniculata is widely cultivated in Sichuan, Shaanxi, Beijing and other places in my country. It has pharmacological effects such as anti-inflammatory, anti-tumor, liver protection and gallbladder. The content of andrographolide in Andrographis paniculata leaves is 1.8%, and the chemical molecular formula is C 20 h 30 o 5 , the molecular weight is 350.44. Studies have found that andrographolide has less toxicity in the body and has a wide range of pharmacological effects. It has antibacterial, anti-inflammatory, anti-apoptotic, anti-tumor, immune-regulating, liver-protec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K31/365A61P11/00A61P31/04
Inventor 金义光李淼杜丽娜朱李飞张桐桐
Owner ACADEMY OF MILITARY MEDICAL SCI
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