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A 3D printed polycaprolactone/oyster shell powder composite material and its preparation and application and bone tissue engineering scaffold based thereon

A technology of bone tissue engineering and oyster shell powder, applied in medical science, prosthesis, etc., can solve the problems of lack of cell recognition sites, low immunogenicity, slow degradation rate, etc., to improve biological activity and osteogenesis effect , good biocompatibility, and short production cycle

Active Publication Date: 2019-09-17
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hydrophobic polyester material - polycaprolactone has excellent biocompatibility and biodegradability, has been certified by FDA for clinical use, and has been widely used in the research of bone tissue engineering scaffolds. In addition, polycaprolactone The processing and forming performance of ester is quite excellent, because polycaprolactone not only has good mechanical properties but also has a low melting point, which makes polycaprolactone can be easily processed into designed shapes. However, years of research have shown that polycaprolactone The surface of caprolactone lacks sites for cell recognition, slow degradation rate, and hydrophobicity. Therefore, polycaprolactone is seldom used alone for the preparation of tissue engineering scaffolds; oyster shells are naturally formed and rich in amino acids and trace metal elements. Mineral salts, the accumulation of inorganic salts is very similar to bone deposition, therefore, oyster shells have low immunogenicity, good biocompatibility, degradability, osteoconductivity and osteogenic properties

Method used

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  • A 3D printed polycaprolactone/oyster shell powder composite material and its preparation and application and bone tissue engineering scaffold based thereon
  • A 3D printed polycaprolactone/oyster shell powder composite material and its preparation and application and bone tissue engineering scaffold based thereon
  • A 3D printed polycaprolactone/oyster shell powder composite material and its preparation and application and bone tissue engineering scaffold based thereon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A kind of 3D printing technology to prepare polycaprolactone / oyster shell powder composite three-dimensional porous bone tissue engineering scaffold, comprising the following steps:

[0050] 1) Dry polycaprolactone (molecular weight: 60,000-80,000, melting point: 60-65° C.) and oyster shell powder in a drying oven at 40° C. for 24 hours, and set aside.

[0051] 2) Weigh 190g of polycaprolactone granules and 10g of oyster shell powder, mix them uniformly, add them into the feeding barrel of the twin-screw extruder, and feed them into the twin-screw extruder at a feeding speed of 40rpm / min to extrude Out, the parameters of the twin-screw extruder are set as follows: zone 1: 75°C, zone 2: 90°C, zone 3: 110°C, zone 4: 90°C, zone 5: 80°C, extrusion speed: 90rpm / min.

[0052] 3) The extruded spline is cooled and shaped by water cooling in the front section and air cooling in the back section, and the water temperature is room temperature.

[0053] 4) Granulate the above-ment...

Embodiment 2

[0058] A kind of 3D printing technology to prepare polycaprolactone / oyster shell powder composite three-dimensional porous bone tissue engineering scaffold, comprising the following steps:

[0059] 1) Dry polycaprolactone (molecular weight: 60,000-80,000, melting point: 60-65° C.) and oyster shell powder in a drying oven at 40° C. for 24 hours, and set aside.

[0060] 2) Weigh 160g of polycaprolactone granules and 40g of oyster shell powder, mix them uniformly, add them to the feeding barrel of the twin-screw extruder, and feed them into the twin-screw extruder at a feeding speed of 40rpm / min to extrude Out, the parameters of the twin-screw extruder are set as follows: zone 1: 75°C, zone 2: 90°C, zone 3: 110°C, zone 4: 90°C, zone 5: 80°C, extrusion speed: 90rpm / min.

[0061] 3) The extruded spline is cooled and shaped by water cooling in the front section and air cooling in the back section, and the water temperature is room temperature.

[0062] 4) Granulate the above-mentio...

Embodiment 3

[0067] A kind of 3D printing technology to prepare polycaprolactone / oyster shell powder composite three-dimensional porous bone tissue engineering scaffold, comprising the following steps:

[0068] 1) Dry polycaprolactone (molecular weight: 60,000-80,000, melting point: 60-65° C.) and oyster shell powder in a drying oven at 40° C. for 24 hours, and set aside.

[0069] 2) Weigh 170g of polycaprolactone granules and 30g of oyster shell powder, mix them uniformly, add them into the feeding barrel of the twin-screw extruder, and feed them into the twin-screw extruder at a feeding speed of 40rpm / min to extrude Out, the parameters of the twin-screw extruder are set as follows: zone 1: 75°C, zone 2: 90°C, zone 3: 110°C, zone 4: 90°C, zone 5: 80°C, extrusion speed: 90rpm / min.

[0070] 3) The extruded spline is cooled and shaped by water cooling in the front section and air cooling in the back section, and the water temperature is room temperature.

[0071] 4) Granulate the above-ment...

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Abstract

The invention belongs to the technical field of tissue engineering and discloses a 3D (three-dimensional) printing type polycaprolactone / oyster shell powder composite material, a preparation method and application thereof and a bone tissue engineering scaffold based on the 3D printing type polycaprolactone / oyster shell powder composite material. The 3D printing type polycaprolactone / oyster shell powder composite material comprises polycaprolactone and oyster shell powder in a mass ratio of 95:5-80:20. The bone tissue engineering scaffold is excellent in mechanical performance and biocompatibility and has high porosity and a three-dimensional interconnected porous structure by taking the polycaprolactone as a host material and the / oyster shell powder with osteogenic activity as a reinforcing phase. The 3D printing type polycaprolactone / oyster shell powder composite material is applied to 3D printing and can be built into a three-dimensional scaffold model suitable for different patients, different bone defect parts and different bone tissue engineering requirements, excellent scaffold environments can be provided for bone tissue regeneration through controllable porous structures and individually designed shapes, and gold standards on bone defect repair are simulated maximally.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a 3D printed polycaprolactone / oyster shell powder composite material, its preparation method and application, and a bone tissue engineering scaffold based on it. Background technique [0002] There are as many as 3 to 4 million patients with bone defects in my country every year due to traffic accidents, natural disasters, diseases, etc. Bone tissue defects bring great inconvenience to patients' daily life. Bone transplantation is one of the most effective methods to solve the problem of bone defects. At present, autologous bone, allogeneic bone and xenograft bone transplantation can be used to treat bone defects clinically. However, there are obvious defects in these therapeutic methods. Autologous bone grafting is currently the gold standard for repairing bone defects. Not only does it have no immune rejection, but it can completely replace the original ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/56
Inventor 敖宁建罗文峰
Owner JINAN UNIVERSITY
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