A kind of amino acid-containing compound polymer colloid wound disinfectant and its preparation method
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A technology of composite polymer and disinfectant, which is applied in the field of medical drugs, can solve the problems of complex preparation methods and achieve good stability, promote wound repair, and fast action speed
Active Publication Date: 2019-11-05
GUIZHOU YANGSHENG MEDICAL INSTR
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However, the preparation method of this technology is relatively complicated and requires specific reaction equipment
[0012] Therefore, there is no preparation method in the prior art that is simple, does not require special equipment, and can combine the three antibacterial macromolecules of polyhexamethylene biguanide, ε-polylysine, and chitosan with the macromolecular alcohol phenoxy The technology of compounding ethanol with specific amino acids by means of emulsifiers and solubilizers
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[0038]The core idea of the present invention is: adopt the technology of the present invention, through the preparation of chitosan solution, the preparation of polyhexamethylene biguanide emulsion, the preparation of phenoxyethanol solution and compound four steps, with polyvinylpyrrolidone and porolidone Sham works together as an emulsifier and solubilizer, and uses a mixture of aspartic acid, glutamic acid and cysteine as a regulator and enhancer to convert polyhexamethylene biguanide, ε-polyguanide, which were originally difficult to coexist in the same system Lysine, phenoxyethanol, and non-water-soluble chitosan with a degree of deacetylation greater than 80% and a viscosity-average molecular weight of more than 100,000 are compounded into a composite polymer colloidal wound disinfectant containing amino acids. The composite polymer colloid wound disinfectant can retain the original characteristics of each component, so that a composite polymer colloid wound disinfect...
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Abstract
The invention discloses a composite polymer colloid wound surface disinfectant containing amino acid and a preparation method of the disinfectant. The composite polymer colloid wound surface disinfectant takes polyvinylpyrrolidone and poloxamer as an emulsifier and a solubilizer, takes polyhexamethylene biguanidine, epsilon-polylysine, phenoxyethanol and water-insoluble chitosan with the degree of deacetyiation higher than 80% and the viscosity average molecular weight higher than 100,000 as bactericidal active ingredients and takes an aspartic acid, glutamic acid and cysteine mixture as a modifier and an reinforcing agent. The composite polymer colloid wound surface disinfectant is high in bactericidal capacity, high in acting speed, good in stability, safe and capable of promoting wound surface repair. The preparation method of the composite polymer colloid wound surface disinfectant comprises preparation of the chitosan solution, preparation of a polyhexamethylene biguanidine emulsion, preparation of a phenoxyethanol solution and compounding.
Description
technical field [0001] The invention relates to medical drugs, and furthermore, to a compound polymer colloid wound disinfectant containing amino acids and a preparation method thereof. [0002] technical background [0003] An ideal disinfectant should have a broad spectrum of sterilization, strong bactericidal ability, fast action speed, good stability, non-toxic, no residue, no corrosion, no irritation, easily soluble in water, safe for humans and animals, and cheap and easy to obtain. It has the characteristics of low environmental pollution, and for wound disinfectant, it also needs to help the wound heal. [0004] In the prior art, disinfectants can be generally divided into 9 categories, namely chlorine-containing, peroxides, aldehydes, alcohols, iodine-containing, phenols, ethylene oxide, biguanides and Quaternary ammonium salts. At present, these 9 types of disinfectants all have their own shortcomings, some are poisonous and irritating, harmful to the body, some a...
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