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Vitamin C sodium effervescence formulation and preparation method thereof

An effervescent preparation and vitamin technology, applied in the functions of food ingredients, food shaping, food science, etc., can solve the problems of vitamin C-free sodium effervescent preparations, etc., and achieve no gastrointestinal irritation, easy absorption, and operation simple effect

Inactive Publication Date: 2017-02-15
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching, there are still no vitamin C sodium effervescent preparations and related patents. There are many Chinese invention patents such as vitamin C effervescent tablets (application number: 201310053196.6, authorized), a vitamin C effervescent granule and its preparation method (application number : 201210347555.4, authorized) and the composition and preparation of a vitamin C effervescent tablet (application number: 201410757299.5, open), etc., only focus on the research and development of vitamin C effervescent preparation and its preparation method

Method used

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  • Vitamin C sodium effervescence formulation and preparation method thereof
  • Vitamin C sodium effervescence formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Prescription

[0026] Vitamin C sodium 25wt%, tartaric acid 28wt%, sodium bicarbonate 17wt%, lactose 20wt%, saccharin sodium 1wt%, orange flavor 0.5wt%, PEG-40003wt%, sodium chloride 1.5wt%, micronized silica gel 0.5wt%, 10% PVP k30 absolute ethanol solution 3.5wt%.

[0027] (2) Preparation method

[0028] Sieve vitamin C sodium and tartaric acid separately, add lactose and mix evenly, prepare soft material with an appropriate amount of 10% PVP k30 absolute ethanol solution, sieve to obtain acid granules, and dry the whole granules in a blast drying oven at 40°C; The method uses sodium bicarbonate and lactose to prepare alkaline granules; add appropriate amount of PEG-4000, sodium saccharin, orange flavor, and micropowder silica gel to the two kinds of acid and alkali granules, mix well and then press into tablets.

[0029] (3) Inspection

[0030] The vitamin C sodium effervescent tablet prepared in step (2) was placed in water (15° C., 100 mL) for a disintegrati...

Embodiment 2

[0035] (1) Prescription

[0036] Sodium vitamin C 5wt%, vitamin E 19wt%, tartaric acid 20wt%, sodium bicarbonate 15wt%, cross-linked polyvinylpyrrolidone 15wt%, polyvinylpyrrolidone 5wt%, lactose 17wt%, stevioside 1wt%, polyethylene glycol (PEG ) 60003wt%.

[0037] (2) Preparation method

[0038] Add stevioside to lactose to make it fully absorbed, pass through a 30-40 mesh sieve after drying to obtain lactose granules for later use; sodium vitamin C, tartaric acid, sodium bicarbonate, cross-linked polyvinylpyrrolidone, polyvinylpyrrolidone and polyethylene glycol 6000 After the material is dry, pass through a 100-mesh sieve. Take the prescribed amount of lactose granules and add the prescribed amount of vitamin C sodium, tartaric acid, sodium bicarbonate, cross-linked polyvinylpyrrolidone, polyvinylpyrrolidone and PEG-6000 in an equal increasing method. Mix evenly and press into tablets.

[0039] (3) Inspection

[0040] The vitamin C sodium effervescent tablet prepared i...

Embodiment 3

[0042] (1) Prescription

[0043] Vitamin C sodium 60wt%, citric acid / tartaric acid (mass ratio, 1:1) 17wt%, sodium carbonate / sodium bicarbonate (mass ratio, 1:9) 10wt%, lactose / mannitol (mass ratio, 10:1) 10wt%, 0.2wt% stevia, appropriate amount of absolute ethanol solution, 2.8wt% PEG-6000.

[0044] (2) Preparation method

[0045]Sieve vitamin C sodium, citric acid and tartaric acid separately, then mix evenly according to the ratio in the prescription, add an appropriate amount of absolute ethanol solution to granulate to obtain wet granules I; mix sodium carbonate, sodium bicarbonate, lactose and mannitol and add Appropriate amount of anhydrous ethanol solution was granulated to obtain wet granules II; wet granules I and II were dried and mixed, added stevioside and polyethylene glycol, mixed and pressed into tablets, and finally obtained effervescent tablets.

[0046] (3) Inspection

[0047] The vitamin C sodium effervescent tablet prepared in step (2) was disintegrated...

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Abstract

The invention belongs to the field of health-care products, and particularly relates to a vitamin C sodium effervescence formulation and a preparation method thereof. The vitamin C sodium effervescence formulation provided by the invention comprises acidic components, alkaline components, a filling agent, a correctant, a lubricant, an adhesive and a disintegration auxiliary. The effervescence formulation is an effervescent tablet agent or effervescence solid particles, is good in stability and free from irritant to the stomach and the intestinal tracts, and can be effectively used as a supplementing agent of vitamin C. The invention further discloses the preparation method of the effervescence formulation. The preparation method is simple to operate. The prepared vitamin C sodium effervescence formulation is smooth, clean and level in appearance, free from bubbling phenomena, large in effervescence particle size and low in hygroscopicity.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to a vitamin C sodium effervescent preparation and a preparation method thereof. Background technique [0002] Sodium vitamin C is the sodium salt of vitamin C. Its physiological function is similar to that of vitamin C. It is an important nutrient involved in the metabolism of the body. It has the following functions in the metabolism of the body: it can not only promote the biosynthesis of collagen, but also It is beneficial to the healing of tissue wounds, and can also promote the metabolism of tyrosine and tryptophan, accelerate the deamination metabolism of proteins or peptides, improve the utilization of iron, calcium and folic acid, and increase the body's ability to respond to external stress, etc. . It is used as a vitamin C supplement in medicine to supplement the deficiency of its intake, and it can be used as an antioxidant in food and some beverages to p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L33/16A23P10/28A23L29/30
CPCA23V2002/00A23V2200/324A23V2200/308A23V2200/30A23V2250/708
Inventor 何燕胡浩鹏郑绵峰赖惠芳武文敬程书朋邓远强黄健文陈泽丰江森龙威张焜郑希
Owner GUANGDONG UNIV OF TECH
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