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Tablet composition containing enalapril and folic acid and preparation method thereof

A technology of folic acid tablet and composition, which is applied in the field of medicine to achieve the effect of slowing down the dissolution rate

Active Publication Date: 2017-01-11
SHENZHEN AUSA PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The object of the present invention is to provide a kind of tablet composition taking enalapril and folic acid as active components and preparation method thereof, solve the problem of the stability of enalapril and folic acid two kinds of active components in this preparation on the one hand, Improved safety and stability of formulations

Method used

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  • Tablet composition containing enalapril and folic acid and preparation method thereof
  • Tablet composition containing enalapril and folic acid and preparation method thereof
  • Tablet composition containing enalapril and folic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Enalapril Maleate Folic Acid Tablets

[0034]

[0035]

[0036] Preparation:

[0037] Get enalapril maleate and pulverize through 100 mesh, set aside. Take the prescribed amount of folic acid and mix it with 50% of the prescribed amount of glyceryl behenate, grind the mixture and then mix it with the disintegrating agent crospovidone XL-10; add enalapril maleate and mix; Mix gelatinized starch and microcrystalline cellulose, add 8% povidone solution (90% ethanol as solvent) to granulate, add remaining glyceryl behenate and mix to obtain enalapril maleate folic acid tablet intermediate product granules, Detection, tablet pressing.

Embodiment 2

[0038] Example 2: Enalapril Maleate Folic Acid Tablets

[0039]

[0040] Preparation:

[0041]Get enalapril maleate and pulverize through 100 mesh, set aside. Take the prescribed amount of folic acid and mix the prescribed amount of glyceryl behenate, grind the mixture and then mix it with crospovidone XL-10; add enalapril maleate and mix it; then add lactose, microcrystalline cellulose 112 Mix to obtain the intermediate product of enalapril maleate folic acid tablets, mix powder, test, and tablet to obtain.

Embodiment 3

[0042] Example 3: Enalapril Maleate Folic Acid Tablets

[0043]

[0044]

[0045] Preparation:

[0046] Get enalapril maleate and pulverize through 100 mesh, set aside. Take the prescribed amount of folic acid and mix it with 50% of the prescribed amount of glyceryl behenate, grind the mixture and then mix it with the disintegrating agent crospovidone XL-10; add enalapril maleate and mix it; then add lactose, Mixing microcrystalline cellulose 112, dry granulation, adding remaining glyceryl behenate and mixing to obtain enalapril maleate folic acid tablet intermediate product granules, testing, and tableting.

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Abstract

The invention relates to a tablet composition containing enalapril and folic acid and a preparation method thereof. The tablets prepared by the preparation method are capable of effectively reducing the degradation of active ingredients of a medicine while improving the stability and safety of a compound solid preparation as well as the disintegration rate and timeliness of the medicine in the stomach and intestines; the composition meets the dosage requirements for accurate absorption, and the therapeutic effect of the medicine is remarkably improved.

Description

[0001] Technical field: [0002] The invention relates to the technical field of medicine, in particular to a tablet composition containing enalapril and folic acid and a preparation method thereof. [0003] Background technique: [0004] Enalapril is an ACEI drug. After oral administration, it is rapidly hydrolyzed into Enalaprilat in the body. The latter strongly inhibits angiotensin-converting enzyme, reduces the content of angiotensin Ⅱ and aldosterone, and at the same time reduces the risk of slowing down. Kinide degradation can promote the release of prostaglandins, and can also inhibit local tissues such as kidneys, blood vessel walls and brain angiotensin-converting enzymes, relax blood vessels, reduce total peripheral resistance, and lower blood pressure. It is used to treat essential hypertension. [0005] Combination of folic acid and ACEI can enhance the antihypertensive effect of ACEI. Folic acid alone has a mild antihypertensive effect; folic acid can directly im...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K9/20A61K47/38A61K47/32A61K47/14A61P9/12A61P9/10A61P9/04A61P9/06A61P3/06A61P3/10A61P13/12A61K31/519
CPCA61K9/2013A61K9/2027A61K9/2054A61K31/519A61K38/05A61K2300/00
Inventor 陈平陈亚宁罗建平于多王滨燕刘平徐希平田敏卿
Owner SHENZHEN AUSA PHARM CO LTD
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