Methylene bridging 1,8-naphthyridine ligand and copper (I) complex, preparing method and application
A methylene bridge and complex technology, applied in the chemical field, can solve the problems of high cost, toxic and harmful heavy metal residues, etc., and achieve the effect of shortening the reaction process and simplifying raw materials
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[0042] 1. Synthesis of methylene bridged 1,8-naphthyridine ligand and copper (I) complex:
[0043] 1) Synthesis of 2-methyl-4-R 1 -7-Acetamido-1,8-naphthyridine:
[0044] Add 7-amino-2,4-dimethyl-1,8-naphthyridine or 7-amino-2-methyl-1,8-naphthyridine (4.0 g, 23.1 mmol) into a 100 mL round bottom flask, add 15mL of acetic anhydride, the mixture was refluxed for 2h under the protection of nitrogen, and the reaction liquid was cooled to precipitate yellow crystals, which were filtered to obtain 7-acetamido-2,4-methyl-1,8-naphthyridine or 7-acetamido-2-methyl -1,8-naphthyridine product is directly used in the following reaction;
[0045] 2) No catalyst SP 3 Synthesis of methylene bridged 1,8-naphthyridine ligands by C—H activation:
[0046] Dissolve 0.35g (2.33mmol) o-aldehyde benzoic acid in 30mL N,N-dimethylformamide, raise the temperature to 150°C under nitrogen protection, and then add 0.50g (2.32mmol) 7-acetamido-2,4 -Dimethyl-1,8-naphthyridine and continue to reflux for ...
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