Beta-elemene controlled-release eluting stent for preventing and treating coronary artery in-stent restenosis
A technology for eluting stents and elemene, which is applied in the field of biomedicine and medical materials, to achieve good tissue compatibility and safety, reduce the degree, and prevent restenosis
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Embodiment 1
[0018] Take the dried rhizome of Curcuma officinalis (origin: Ruian, Zhejiang), crush it into a coarse powder, weigh 100g, add it to a 1000ml flask, add 8 times the amount of water, and extract it with a volatile oil extractor for 6 hours (extraction conditions were optimized by orthogonal experiments). Obtain an oily substance with a special smell, that is, zedoary oil, with a content of 2%. Distill the zedoary oil under reduced pressure, collect the elemene fraction at 50°C-80°C / 40Pa, and then carry out vacuum distillation on this fraction The fractions at 70°C-72°C / 40Pa were collected, separated by silica gel column chromatography, and eluted with petroleum ether to obtain the product: a single β-elemene.
Embodiment 2
[0019] Example 2 Preparation of β-elemene controlled-release elution stent
[0020] Using stainless steel stents, polybutyl methacrylate / nano-silicon dioxide composite material as drug controlled release coating, first prepare 1% tetrahydrofuran solution of polybutyl methacrylate, which contains 20% to 25% polymer Nano-silica, adding the β-elemene drug into the solution, making the weight ratio of the drug to polybutylmethacrylate 1:1, stirring to suspend the drug in the solution, and spraying the suspension evenly Spray on the stent, dry at 40°C, weigh accurately, and calculate the drug content per square millimeter of the stent surface; the coating thickness is 10-35 μm, and the drug content on the stent surface is 7.1 μg-28.4 μg / mm 2 , install the drug-eluting stent on the balloon, and sterilize it with ethylene oxide for use;
[0021] The in vitro controlled release test of the β-elemene controlled release elution stent showed that the drug was released rapidly in the ini...
Embodiment 3
[0022] Embodiment 3 animal experiments
[0023] Animal experiments were conducted to test the effect of β-elemene controlled-release eluting stent on intimal hyperplasia after stenting in experimental animals, and to evaluate the safety and efficacy of β-elemene controlled-release-eluting stent in preventing restenosis after stenting:
[0024] Healthy Chinese miniature pigs were randomly divided into 2 groups: according to the ratio of stent diameter and coronary artery diameter of 1.2 to 1.3:1, the simple coating stent and the β-elemene controlled-release eluting stent of Example 1 were respectively used. The coating thickness 10μm, the drug content on the surface of the stent is 7.1μg / mm 2 Randomly implant suitable vascular segments of the circumflex branch and anterior descending branch, including coating group and β-elemene group, 12 rats in each group, taking aspirin 250mg 2 days before the operation and stopping after the operation, 1 month and 6 rats Six animals were s...
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