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Detection method of child Jiegan traditional Chinese medicine preparation

A technology for the detection and detection of children's anti-sensitivity, which is applied in the field of medicine, can solve the problem of not being able to accurately measure the content of ingredients such as Folium Folium Folium and Platycodon grandiflorum in children's anti-sensitivity preparations, and achieve the effects of simple operation, good reproducibility, and accurate analysis data

Active Publication Date: 2016-11-16
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] To sum up, there is no method in the prior art that can accurately determine the content of Folium Folium and Platycodon grandiflorum in Xiaoer Jiegan preparation, and the method for determining the content of Folium Folium and Platycodon grandiflorum in other medicinal materials is not suitable for Xiaoer Jiegan preparation

Method used

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  • Detection method of child Jiegan traditional Chinese medicine preparation
  • Detection method of child Jiegan traditional Chinese medicine preparation
  • Detection method of child Jiegan traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0061] Experimental Example 1: Determination of Folium Folium

[0062] 1. Instruments, reagents and test samples

[0063] Instruments: High performance liquid chromatography: Agilent 1260, G1311C infusion pump, G1329B automatic sampling system, G1315D diode array detector, Waters Empower3 workstation; METTLER TOLEDO XPE205 electronic balance.

[0064] Reference substance: indirubin reference substance (China Institute for the Control of Pharmaceutical and Biological Products), batch number: 110717-200204.

[0065] Test sample: Xiaoer Jiegan Granules (Shandong Mingren Freda Pharmaceutical Co., Ltd.), batch numbers: 16105009, 16105010, 16105011.

[0066] 2. Chromatographic conditions

[0067] Determine according to high performance liquid chromatography (Chinese Pharmacopoeia 2015 edition general rule 0512).

[0068] Octadecylsilane-bonded silica gel is used as filler; methanol-acetonitrile-water is used as mobile phase at a volume ratio of 55:20:25, the detection wavelength ...

experiment example 2

[0117] Experimental Example 2: Content Determination of Campanulaceae

[0118] 1. Instruments, reagents and test samples

[0119] Instruments: High performance liquid chromatography: Agilent 1260, G1311C infusion pump, G1329B automatic sampling system, G1315D diode array detector, Waters Empower3 workstation; METTLER TOLEDO XPE205 electronic balance.

[0120] Reference substance: platycodon saponin D reference substance (China Institute for the Control of Pharmaceutical and Biological Products) batch number: 11851-201406.

[0121] Test sample: Xiaoer Jiegan Granules (Shandong Mingren Freda Pharmaceutical Co., Ltd.) Batch numbers: 16105009, 16105010, 16105011.

[0122] 2. Chromatographic conditions

[0123] Determine according to high performance liquid chromatography (Chinese Pharmacopoeia 2015 edition general rule 0512).

[0124] Octadecylsilane bonded silica gel is used as filler; 0.1% by volume trifluoroacetic acid solution is used as mobile phase A, acetonitrile is used a...

Embodiment 1

[0182] A detection method of traditional Chinese medicine Xiaoer Jiegan preparation, comprising the following content determination methods:

[0183] (1) Determination of Folium Folium

[0184] Chromatographic conditions and system suitability test:

[0185] Measure according to Chinese Pharmacopoeia 2015 edition four 0512 high performance liquid chromatography:

[0186] Octadecylsilane bonded silica gel is used as the filler; methanol-acetonitrile-water is used as the mobile phase at a ratio of 55:20:25 by volume, the detection wavelength is 290nm, and the flow rate is 1.0mL / min;

[0187] Preparation of reference substance solution: Take an appropriate amount of indirubin reference substance, weigh it accurately, dissolve and dilute with methanol to make a solution containing 1 μg per 1 mL, and obtain it;

[0188] Preparation of the test solution: Take Xiao’er Jiegan Granules, grind the contents finely, take 2.2g of the mixed powder, weigh it accurately, put it in a stopper...

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Abstract

The invention discloses a detection method of a child Jiegan traditional Chinese medicine preparation. The content of indigowoad leaves and the content of platycodon roots in the child Jiegan traditional Chinese medicine preparation are determined with high performance liquid chromatography. The method is convenient to operate, analyzed data are accurate, and the product quality is safe, stable and controllable.

Description

technical field [0001] The invention relates to a detection method of a traditional Chinese medicine compound preparation, in particular to a detection method of a traditional Chinese medicine antisense preparation for children, and belongs to the technical field of medicine. Background technique [0002] Xiaoer Jiegan Tablets are included in the 2015 edition of the Chinese Pharmacopoeia. It can clear away heat and relieve exterior syndrome, relieve throat and relieve cough. For cold and fever, headache and stuffy nose, cough and sneeze, sore throat. Xiao'er Jiegan Tablets are made of raw materials with the following weight ratio: 830 grams of Daqingye, 415 grams of Bupleurum, 415 grams of Scutellaria, 415 grams of Nepeta, 250 grams of Campanulaceae, and 165 grams of Licorice. Xiaoer Jiegan Granules are not recorded in any pharmacopoeia, and the formula is the same as Xiaoer Jiegan Tablets. Xiaoer Jiegan Granules are favored by patients clinically due to their good effect ...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 吴世德贾美春江玉娟潘瑞雪孙桂雪马丽君
Owner SHANDONG MINGREN FURUIDA PHARMA
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