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Fenbendazole nano suspension and preparation method thereof

A nano-suspension, fenbendazole technology, applied in the direction of emulsion delivery, drug combination, liquid delivery, etc., can solve the problem of insolubility, achieve the effect of improving effectiveness, uniform drug particle size distribution, and increasing saturation solubility

Inactive Publication Date: 2016-10-05
HENAN HUITONG TIANXIA BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is that fenbendazole is insoluble in water and most organic solvents. In recent years, along with the development of preparation technology, preparation workers have taken many methods to solve this problem, such as: use mixed solvents, adopt packaging However, there are some problems in these methods, in order to solve the above problems, a kind of fenbendazole nano-suspension and its preparation method are provided

Method used

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  • Fenbendazole nano suspension and preparation method thereof
  • Fenbendazole nano suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A mixed suspension of fenidazole, components of the following mass scores: fertilizazole 2 ~ 8%, suspension 0.5 ~ 2%, wetting agent 0.05 ~ 0.15%, flocculant 0.5 ~ 2%, Bacteriostatic agent 0.05 ~ 0.15%, the balance is injection water.

[0025] The suspension of suspension is at least one in methyl cellulose, sodium carboxymethyl cellulose, hydroxyl cellulose, sodium alginate, and Arabia.

[0026] The wetting agent is at least one in ethanol, propylene glycol, glycerin, vomitor-80, and polyethylene glycol 200.

[0027] The flocculant is at least one of the winestology, phosphate, and citric acid.

[0028] The bacteriostatic agent is at least one of the phenylnanol, phenol, and sodium benzoate.

[0029] Including the following steps:

[0030] (1) Soluble suspension, flocculant, bacteriostatic agent in injection water, stir well to get mixture A;

[0031] (2) Take the moisturizing agent in the injection water, then add feenzazole, stir well to get the mixture B;

[0032] (3) Ad...

Embodiment 2

[0036] A phenazndazole nano -mixed suspension consists of components of the following mass scores: 2%fenalazole, 0.5%methyl cellulose, 0.05%ethanol, 0.5%in wine acid, 0.05%benzinyl alcohol.Water for Injection.

[0037] Including the following steps:

[0038] (1) Soluble suspension, flocculant, bacteriostatic agent in injection water, stir well to get mixture A;

[0039] (2) Take the moisturizing agent in the injection water, then add feenzazole, stir well to get the mixture B;

[0040] (3) Add the mixture A to the mixture B, add injection water to the full amount, mix well, grind with glue grinding, to be mixed with suspension;

[0041] (4) Mix the rough suspension obtained in steps (3) through high -speed homogeneous dispersers, circulate 3 times in average under 10MPa pressure, and cycle the average mass of 100MPA under 100MPa pressure.Filter, the dove penalizole nano -mixed suspension.

Embodiment 3

[0043] A phenazndazole nano -mixed suspension, components of the following mass scores: 3%fenalazole, 0.6%of sodium carboxymethyl cellulose, 0.06%propylene glycolThe amount is injection water.

[0044] Including the following steps:

[0045] (1) Soluble suspension, flocculant, bacteriostatic agent in injection water, stir well to get mixture A;

[0046] (2) Take the moisturizing agent in the injection water, then add feenzazole, stir well to get the mixture B;

[0047] (3) Add the mixture A to the mixture B, add injection water to the full amount, mix well, grind with glue grinding, to be mixed with suspension;

[0048] (4) Mix the rough suspension obtained in steps (3) through high -speed homogeneous dispersers, circulate 4 times in average under 15MPa pressure, 110MPa pressure 11 times under pressure, with 0.45 μm microporous filter membrane filter membranesFilter, the dove penalizole nano -mixed suspension.

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Abstract

The invention discloses a fenbendazole nano suspension which is composed of, by mass, 2-8% of fenbendazole, 0.5-2% of a suspending agent, 0.05-0.15% of a wetting agent, 0.5-2% of a flocculating agent, 0.05-0.15% of an antibacterial agent and the balanced being water for injection. Compared with the prior art, the fenbendazole is processed into the nano suspension, so that saturated solubility, dissolving rate and mucous membrane adhesion are improved, a problem of low bioavailability of the medicine is overcome and effectiveness, safety and stability of the medicine are improved. The preparation method and formula in the invention are simple. The fenbendazole nano suspension has uniform particle size distribution, is easy to apply and is suitable for industrial production. The nano suspension has excellent stability, improves solubility and oral-taking bioavailability of fenbendazole, is reduced in toxic and side effects and has excellent practical value and application prospect.

Description

Technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and specifically relates to a fenbendazole nanosuspension and a preparation method thereof. Background technique [0002] Fenbendazole, also known as albendazole, is a derivative of benzimidazole. This drug has a broad anti-insect spectrum, low toxicity, high efficiency and low price. It is widely used to treat and prevent hookworms and hookworms in humans and animals. Ascariasis, whipworm, pinwormiasis, trichinellosis, taeniasis and cysticercosis are also used to treat strongyloidiasis stercoralis. So far, fenbendazole is considered to be one of the anthelmintic drugs with the widest anthelmintic spectrum and the strongest insecticidal effect among the benzimidazole drugs. Fenbendazole is insoluble in water and most organic solvents. With the development of preparation technology in recent years, preparation workers have adopted many methods to solve this problem, such as u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/4184A61P33/10
Inventor 张要齐李引乾张粉丽孙雪峰刘三侠
Owner HENAN HUITONG TIANXIA BIO ENG
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