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Method for improving mechanical properties of polycaprolactone-based biological elastomer

A technology of elastomer and caprolactone, which is used in prosthesis, medical science and other directions, can solve the problems of limited application and poor mechanical properties, and achieve the effect of wide application range, good curing molding method and high tensile strength.

Inactive Publication Date: 2016-09-14
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the traditional molding of polyester-based materials based on PGS, PPS, PLA, etc. needs to be cured at high temperature or in the presence of organic solvents (Synthesis, preparation, in vitro degradation, and application of novel degradable bioelastomers—A review, Progress in Polymer Science 37(2012), 715-765), and the cross-linked liquid polycaprolactone-based elastomer in previous studies can be molded without solvent at room temperature, but its poor mechanical properties limit its application in tissue engineering (Cross-linked polycaprolactone and its preparation method and use, publication number CN103626979A, publication date 2014-3-12)

Method used

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  • Method for improving mechanical properties of polycaprolactone-based biological elastomer
  • Method for improving mechanical properties of polycaprolactone-based biological elastomer

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Embodiment 1

[0040] What the present embodiment provides is the preparation of BDM-PMCL different molecular weight prepolymers, the preparation method is with reference to prior patent application CN103626979A[0038], compared with prior patent application, the change is that terephthalyl dimethanol (BDM, initiator ) and 4-methyl-ε-caprolactone (MeCL), the molar ratios of initiator to monomer were 1:50, 1:100, 1:200, 1:250, 1:300, 1:400 ; That is, in the present embodiment, the degree of polymerization n is 50, 100, 200, 250, 300, and 400, respectively, and six gradients are used to obtain the BDM-PMCL prepolymer Ia.

[0041] The end group modification method refers to the prior patent application CN103626979A [0038] to obtain the BDM-PMCL prepolymer Ib, and the composition is shown in Table 1 below.

[0042] Table 1 Synthesis and component characterization of polycaprolactone-based linear prepolymer

[0043]

[0044]The BDM-PMCL prepolymer Ib prepared in this embodiment is compared wit...

Embodiment 2

[0050] What the present embodiment provides is the preparation of 4s-PE-PMCL prepolymer, and preparation method refers to prior patent application CN103626979A [0038], changes initiator into pentaerythritol, and changes pentaerythritol (PE) and 4-methyl-ε- The molar ratios of caprolactone (MeCL) are 1:50, 1:100, 1:200, 1:250, 1:300, 1:400 respectively, and the degree of polymerization n is 50, 100, 200 respectively in this embodiment , 250, 300, 400 six gradients to get 4s-PE-PMCL prepolymer IIa.

[0051] The terminal group modification method refers to the prior patent application CN103626979A [0038] to obtain BDM-PMCL prepolymer IIb, and the composition is shown in the following table.

[0052] Table 2 Synthesis and component characterization of polycaprolactone-based star prepolymer

[0053]

[0054] Compared with the corresponding product obtained in the previous patent application CN103626979A, "Synthesis and application of amorphous polyester based on 4-methyl-ε-capr...

Embodiment 3

[0060] This embodiment relates to a method for preparing a bioelastomer with high mechanical properties, comprising the following steps:

[0061] According to the method described in Example 1, prepolymers with different molecular weights are obtained, which are abbreviated as: a: BDM-PMCL 50 , b: BDM-PMCL 100 , c: BDM-PMCL 200 , d: BDM-PMCL 250 , e: BDM-PMCL 300 , f: BDM-PMCL 400 .

[0062] Add photoinitiator (benzoin dimethyl ether) respectively in above-mentioned six kinds of prepolymers, photoinitiator and prepolymer molar ratio are 1:20, add tetrafluoroethylene template after mixing, with 500W, 365nm ultraviolet light The six kinds of cross-linked polymer samples with fixed sizes were obtained by light irradiation for 10 min respectively. National standard sample preparation was adopted to prepare dumbbell-shaped specimens, and the mechanical properties were tested with a universal testing machine, and the tensile test was carried out at room temperature. The resul...

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Abstract

The invention provides a method for improving mechanical properties of a polycaprolactone-based biological elastomer. The elastomer prepared by the method has high elasticity, the elastic modulus can be adjusted from 0.1 MPa to 3.0 MPa, the tensile strength can be adjusted from 0.2 MPa to 4.0 MPa, and the elongation at break can be adjusted from 100% to 1000%. The elastomer is biodegradable, the designed structure size is adjusted by a fast printing molding technology, and the elastomer with a three-dimensional structure and arbitrary shape can be obtained. The biological elastomer molded by the 3DP technology can achieve construction of a millimeter level structure, and has good enough strength to maintain the shape.

Description

technical field [0001] The invention relates to a method for improving the mechanical properties of polycaprolactone-based bioelastomers, specifically changing the viscosity of prepolymers and the mechanical properties of crosslinked polymers by changing the molecular weight and topological structure of polymers. And apply it to three-dimensional rapid prototyping to prepare elastomers. Background technique [0002] Novel biomaterials based on degradable bioelastomers are mainly used in soft tissue engineering and drug delivery systems. Synthetic biodegradable bioelastomers currently have remarkable characteristics: the three-dimensional cross-linked network structure is similar to natural elastin; it has a high degree of flexibility and elasticity; it can provide mechanical stimulation for tissue engineering structures; performance; and broad biodegradability that can be directly tuned by cross-link density. [0003] However, the traditional molding of polyester-based mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91C08G63/08A61L27/18A61L27/50
CPCA61L27/18A61L27/50C08G63/08C08G63/912C08L67/04
Inventor 肖艳郎思睆郎美东
Owner EAST CHINA UNIV OF SCI & TECH
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