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Skin filler used for injection and preparing method and application thereof

A technology for dermal fillers and injections, applied in the field of dermal fillers for injections and its preparation, can solve the problems of stimulating autoimmune disorders, increasing occurrence position shift, impaired skin metabolism, etc., achieving good biocompatibility, The effect of increasing the load factor and reducing the risk of surgery

Inactive Publication Date: 2016-07-13
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The materials used in the current injectable dermal fillers are mainly divided into two categories: absorbable and non-absorbable. The non-absorbable polymer materials are mainly polymethyl methacrylate, etc., because they cannot be decomposed in the human body and cannot be absorbed by tissues. , it is very easy to form a firm fibrous cyst at the injection site, which increases the risk of positional movement and stimulation of autoimmune disorders, so it is gradually replaced by absorbable materials; absorbable materials are represented by polylactic acid, because polylactic acid has a long acting time , and polylactic acid particles stimulate the hyperplasia of subcutaneous tissue at the injection site, so they can still play a wrinkle-removing effect after degradation. Settling of polylactic acid particles occurs, requiring high operating skills
Over time, oxidative free radicals in the human body gradually increase, which damages skin metabolism, reduces collagen synthesis, and reappears wrinkles. Therefore, it is urgent to study injectable dermal fillers for long-term prevention and treatment of skin aging

Method used

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  • Skin filler used for injection and preparing method and application thereof

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preparation example Construction

[0029] The present invention also includes a preparation method of a dermal filler for injection, comprising the following steps:

[0030] ①Add ethylene glycol monomethyl ether into a vacuum reaction flask, add stannous octoate, lactic acid and glycolic acid after vacuum dehydration to obtain a mixed solution, and react the mixed solution under vacuum conditions at 145~155°C for 8~12 hours to obtain Reaction solution; the mass ratio of the ethylene glycol monomethyl ether, stannous octoate, lactic acid and glycolic acid is 3~8:0.02~0.2:70~90:5~20;

[0031] ②Add dichloromethane to dissolve the reaction solution obtained in step ①, then add ethanol and stir to obtain a precipitate, and vacuum-dry the obtained precipitate at 45~55°C for 45~50 hours to obtain polyethylene glycol-polylactic acid-glycolic acid block copolymerization Material MPEG-PLGA; The mass volume ratio of described step 1. gained reaction solution, methylene chloride and ethanol is 1g: 3 ~ 5ml: 1 ~ 3ml;

[003...

Embodiment 1

[0048] A dermal filler for injection, consisting of the following raw materials: 7g of sodium carboxymethylcellulose, 9g of mannitol and 11g of hydrophilic modified polylactic acid microspheres loaded with antioxidant factors; the hydrophilic modified polylactic acid microspheres It is a porous microsphere composed of polyethylene glycol-polylactic acid-glycolic acid block copolymer MPEG-PLGA. The particle size of the hydrophilic modified polylactic acid microsphere is 30 microns, and the specific surface area is 1m 2 / g, the antioxidant factor is superoxide dismutase.

Embodiment 2

[0050] A dermal filler for injection, consisting of the following raw materials: 9 g of sodium carboxymethylcellulose, 11 g of mannitol and 13 g of hydrophilic modified polylactic acid microspheres loaded with antioxidant factors; the hydrophilic modified polylactic acid microspheres It is a porous microsphere composed of polyethylene glycol-polylactic acid-glycolic acid block copolymer MPEG-PLGA, the particle size of the hydrophilic modified polylactic acid microsphere is 150 microns, and the specific surface area is 12m 2 / g, the antioxidant factor is grape seed extract.

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Abstract

The invention discloses skin filler used for injection and a preparing method and application thereof.The skin filler used for injection is composed of sodium carboxymethylcellulose, mannitol and hydrophilic modified polylactic acid microspheres loading an antioxidant factor.Sodium carboxymethylcellulose, mannitol and hydrophilic modified polylactic acid microspheres loading the antioxidant factor are adopted to form the skin filler used for injection, wherein a polyethylene glycol-polylactic acid-hydroxyacetic acid segmented copolymer is adopted as a raw material of the hydrophilic modified polylactic acid microspheres loading the antioxidant factor, the material is good in biocompatibility and moderate in degradation time, and no residue exists in the human body; the preparing method of the skin filler used for injection is easy to operate and facilitates industrial production, activity of the antioxidant factor can be reserved by the process, and by the adoption of the freeze-drying process, the porous microspheres which are high in dissolution speed, uniform in morphology, high in encapsulation efficiency and stable in slow release can be prepared and used for meeting structural design requirements and clinical needs.

Description

technical field [0001] The invention relates to the technical field of fillers, in particular to a dermal filler for injection and its preparation method and application. Background technique [0002] The materials used in the current injectable dermal fillers are mainly divided into two categories: absorbable and non-absorbable. The non-absorbable polymer materials are mainly polymethyl methacrylate, etc., because they cannot be decomposed in the human body and cannot be absorbed by tissues. , it is very easy to form a firm fibrous cyst at the injection site, which increases the risk of positional movement and stimulation of autoimmune disorders, so it is gradually replaced by absorbable materials; absorbable materials are represented by polylactic acid, because polylactic acid has a long acting time , and polylactic acid particles stimulate the hyperplasia of subcutaneous tissue at the injection site, so they can still play a wrinkle-removing effect after degradation. The...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L31/06A61L31/042A61L31/146A61L31/148A61L31/16A61L2300/254A61L2300/30A61L2300/62
Inventor 王宪朋刘阳杜旭马丽霞王传栋王勤董浩李俊起朱爱臣沈新春
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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