Pharmaceutical preparation for treating male infertility and application thereof

A technology for male infertility and pharmaceutical preparations, applied in the field of medicine, can solve the problems of long treatment course, non-specific immunosuppressive effect, and low overall curative effect, and achieve the effects of safe medication, no adverse reactions, and simple preparation methods

Inactive Publication Date: 2016-07-13
张雪燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the immunosuppressive effect of prednisone is non-specific, and it can inhibit both abnormal immune responses and normal immune responses. Therefore, although it can significantly reduce AsAb in serum and seminal plasma, the overall effect on AsAb positive is not high. , and the course of treatment is long, usually 6 to 12 months
Long-term use of large doses of prednisone is prone to serious side effects, such as peptic ulcer, acne, central obesity, etc., which limits the application of prednisone in the treatment of AsAb positive (Qiu Mingming, Wang Dong, Xiong Guobing, Systematic review on the treatment of immune male infertility with kidney-clearing and heat-reinforcing traditional Chinese medicine compound [J]. Chinese Journal of Andrology, 2007, 21(6):37-42.)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0015] Weigh 4.3 kg of horsetail, 4.3 kg of five-color plum root, 1.2 kg of elm bark, 0.8 kg of Eucommia and 0.8 kg of cnidium, add water to decoct twice, add water for the first time to 12 times the total weight of the medicinal materials, and decoct 2h, add water for the second time to 10 times the total weight of the medicinal materials, decoct for 1.5h, combine the decoction, 0.08MPa, 70°C and concentrate under reduced pressure until the relative density is 1.15 at 70°C, add 95% (v / v) Ethanol to make the alcohol content reach 75% (v / v), stir, stand overnight, filter, and the filtrate is concentrated under reduced pressure at 0.08MPa and 65°C to obtain an extract with a relative density of 1.25g / mL at 65°C. The extract is placed in a stainless steel pan, vacuum-dried (below 60°C) into a dry paste, and crushed.

Embodiment 2

[0016] Embodiment 2: the preparation of Chinese medicine preparation

[0017] Weigh the dry paste powder of traditional Chinese medicine prepared in Example 1, add an appropriate amount of water and sucrose to prepare an oral liquid; or add an appropriate amount of fillers, disintegrating agents and binders to granulate and granulate, and then mix with a lubricant to form granules agent.

Embodiment 3

[0018] Example 3: Study on the treatment of AsAb-positive animal model mice with extracts of traditional Chinese medicine

[0019] Fifty-eight 10-week-old Kunming male adult mice, weighing 25-30 g, were taken. Breeding environment: air-conditioned room temperature around 20°C, relative humidity (55±10)%, lighting / darkness 12 / 12h, feeding and drinking, free intake. Among them, 18 were used to extract mouse sperm, 10 were used as normal controls, and 30 were used to make animal models. Eighteen 10-week-old male mice were sacrificed by cervical dislocation, and their epididymis tissues were collected, cut into pieces in normal saline, incubated at 36°C for 15 minutes to fully free the sperm, washed 3 times with PBS, and adjusted the sperm density to 20×10 6 / ml or so. Randomly select 30 adult male mice with a previously obtained density of 20×10 6 / ml of sperm with the same amount of Fruend's complete adjuvant to make sperm suspension, each 0.3ml intraperitoneal injection, imm...

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PUM

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Abstract

The invention discloses a pharmaceutical preparation for treating male infertility and application thereof. The pharmaceutical preparation is prepared from an active ingredient and pharmaceutically acceptable auxiliary materials, and the active ingredient is prepared from, by weight, 36-48 parts of horsetail, 36-48 parts of root of common lantana, 8-16 parts of Siberian elm bark, 6-10 parts of bark of eucommia and 6-10 parts of Fructus cnidii through decocting with water. Animal experiment and clinical experiment studies show that the pharmaceutical preparation can inhibit nonspecific immune injury and reduce tissue pathological injury and can be used for treating infertility of male patients with positive AsAb.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation for treating male infertility and its application. Background technique [0002] Male infertility is an important global health problem. According to foreign statistics, about 20% to 40% of male infertility patients are caused by immune causes (Edited by Dai Xihu. Andrology Special Prescriptions and Herbal Therapeutics [M]. Beijing: Military Medical Science Press, 2007, 283- 285.). Some people in China have determined that the positive rate of antisperm antibody (AsAb) in male infertility patients is 29.7% (Dong Xieliang. Treatment strategies for male and female infertility [A]. Chinese Society of Sexuality. Chinese Sexology Experts Collection [M]. Beijing : Traditional Chinese Medicine Ancient Books Publishing House, 2005, 160-162.). Various components in sperm and seminal plasma have antigenicity, among which sperm antigen is the foc...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P15/08
CPCA61K36/85A61K36/11A61K36/185A61K36/234A61K36/46A61K2300/00
Inventor 张雪燕
Owner 张雪燕
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